Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Bernd Hubner"'
Autor:
Ute Fischer, Christian Ruckert, Bernd Hubner, Olaf Eckermann, Vera Binder, Tamam Bakchoul, Friedhelm R. Schuster, Sylvia Merk, Hans-Ulrich Klein, Monika Führer, Martin Dugas, Arndt Borkhardt
Publikováno v:
Haematologica, Vol 97, Iss 9 (2012)
Background Very severe aplastic anemia is characterized by a hypoplastic bone marrow due to destruction of CD34+ stem cells by autoreactive T cells. Investigation of the pathomechanism by patient-specific gene expression analysis of the attacked stem
Externí odkaz:
https://doaj.org/article/f00399b8fe6b4bb58aedf5218d8aa507
Autor:
Sonja Gudowius, Tim Niehues, Ulrich Göbel, Kirsten Huck, Dominik Schneider, Ruth Knüchel, Catharina Schuetz, Klaus Schwarz, Burkhard Manfras, Wilhelm Friedrich, Oliver Feyen, Arndt Borkhardt, Rein Willemze, Ulrich Pannicke, Bernd Hubner, Mosaad Megahed, Ansgar Schulz
Publikováno v:
New England Journal of Medicine. 358:2030-2038
We describe three unrelated girls who had an immunodeficiency disease with granulomas in the skin, mucous membranes, and internal organs. All three girls had severe complications after viral infections, including B-cell lymphoma associated with Epste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60501abceb7eb9432033515806bf0173
https://doi.org/10.1056/nejmoa073966
https://doi.org/10.1056/nejmoa073966
Publikováno v:
Anatomy and Embryology. 203:375-382
The polycystic ovary is reported to correspond with a high density in intraovarian nerve fibers and their sympathetic hyperresponsiveness. Peptidergic nerves may also be involved in this process. An interaction between nerve fibers and mast cells is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32679576081b5b752c72b520f7fc05e
https://doi.org/10.1007/s004290100165
https://doi.org/10.1007/s004290100165
Publikováno v:
Nucleosides and Nucleotides. 16:727-732
In this work the expression of functional ribonuclease T1 on the surface of the filamentous Escherichia coli phage M13 is described. Ribonuclease T1 was fused to the phage coat protein pIII and functionally displayed on the phage surface as shown by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ce9aa67f6d5c08ce784c5ee3bfbab88
https://doi.org/10.1080/07328319708002941
https://doi.org/10.1080/07328319708002941
Publikováno v:
Journal of Molecular Biology. 252:133-143
Electrostatic interactions between charged residues and the helix dipole in a protein were investigated by protein engineering methods. In ribonuclease T1, two surface-exposed acidic residues (Glu28 and Asp29) are located near the carboxyl terminus o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2355c4184b5beade73437a52aaf73f2e
https://doi.org/10.1006/jmbi.1995.0480
https://doi.org/10.1006/jmbi.1995.0480
Autor:
Christian Ruckert, Ute Fischer, Bernd Hubner, Martin Dugas, Monika Führer, Hans-Ulrich Klein, Olaf Eckermann, Tamam Bakchoul, Vera Binder, Friedhelm R. Schuster, Sylvia Merk, Arndt Borkhardt
Publikováno v:
Haematologica. 97(9)
Background Very severe aplastic anemia is characterized by a hypoplastic bone marrow due to destruction of CD34+ stem cells by autoreactive T cells. Investigation of the pathomechanism by patient-specific gene expression analysis of the attacked stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f1aa6609db2449d7befadde416885a
https://pubmed.ncbi.nlm.nih.gov/22315490
https://pubmed.ncbi.nlm.nih.gov/22315490
Autor:
Friedhelm R, Schuster, Raymund, Buhmann, Susanne, Reuther, Bernd, Hubner, Christine, Grabrucker, Anja, Liepert, Roland, Reibke, Peter, Lichtner, Ting, Yang, Tanja, Kroell, Hans-Jochem, Kolb, Arndt, Borkhardt, Helga, Schmetzer
Publikováno v:
Cancer genomicsproteomics. 5(5)
Recently it was shown that myeloid leukemic cells can be induced to differentiate into leukemia-derived dendritic cells (DCleu), regaining the stimulatory capacity of professional DCs while presenting the leukemic antigen repertoire. But so far, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f375336eb5ee6354656b74bf7b0f4502
https://pubmed.ncbi.nlm.nih.gov/19129558
https://pubmed.ncbi.nlm.nih.gov/19129558
Autor:
Corinna Löhning, Ingrid Pradel, Christine Rothe, Bodo Brocks, Ute Jager, Bernd Hubner, Yvonne Stark, Melanie Boss, Annemarie Honegger, Josef Prassler, Christian Frisch, Renate Bittlingmaier, Michael Bardroff, Tschimegma Bataa, Stefanie Urlinger, Margit Urban
This article describes the generation of the Human Combinatorial Antibody Library HuCAL GOLD. HuCAL GOLD is a synthetic human Fab library based on the HuCAL concept with all six complementarity-determining regions (CDRs) diversified according to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868b23f6bd621c0d3bc30b8ed5d41b9d
https://www.zora.uzh.ch/id/eprint/4814/
https://www.zora.uzh.ch/id/eprint/4814/
Autor:
Eva M. Schier, Bernd Hubner, Silke Reiffert, Matt Dunn, Benno Rattel, Stefan Zahn, Kurt Lobenwein, Mark G. Wing, Corinna Löhning, Michael Tesar, Zoltan Nagy, Titus Kretzschmar, Michael Stanglmaier, Steve Anderson, Angelika Zahradnik, Sigmar Leyer, Elisabeth Thomassen-Wolf, Christoph Brunner, Robert Rauchenberger, Michael Hallek
Publikováno v:
Nature medicine. 8(8)
The Human Combinatorial Antibody Library (HuCAL) was screened for antibodies specific to human leukocyte antigen-DR (HLA-DR) that induce programmed death of lymphoma/leukemia cells expressing the target antigen. The active Fab fragments were affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45b7dbcf79d26bc8cce3016398a15ba
https://pubmed.ncbi.nlm.nih.gov/12152028
https://pubmed.ncbi.nlm.nih.gov/12152028
Publikováno v:
Biochemistry. 38(4)
Attempts to modify the guanine specificity of ribonuclease T1 (RNase T1) by rationally designed amino acid substitutions failed so far. Therefore, we applied a semirational approach by randomizing the guanine binding site. A combinatorial library of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e3b2fd06d15d950f0f5b8f9b717616
https://pubmed.ncbi.nlm.nih.gov/9931000
https://pubmed.ncbi.nlm.nih.gov/9931000