Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Bernd Hauck"'
Autor:
Biao Dong, Xunbao Duan, Hoi Yee Chow, Lingxia Chen, Hui Lu, Wenman Wu, Bernd Hauck, Fraser Wright, Philipp Kapranov, Weidong Xiao
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e86453 (2014)
Recombinant adeno-associated vectors (rAAV) are commonly purified by either chromatography or equilibrium CsCl gradient. Nevertheless, even after purification various cellular proteins often associate with rAAV vector capsids. Such co-purifying cellu
Externí odkaz:
https://doaj.org/article/371a5ff6d6e54b859cb70b1a993f38d3
Autor:
Romuald Corbau, Olga Zelenaia, Katherine A. High, Sterghios Moschos, Helen Lavender, J. Fraser Wright, David Suhy, Bernd Hauck, Kyle Hayes, Shih-Chu Kao, Laurence O. Whiteley, Tin Mao, B E Souberbielle, Curt Scribner, Andrew D. Burdick, Hubert Denise, Sara H Renison, Alexander A. Kolykhalov, Shangzhen Zhou, Kevin Brady, Peter W. Roelvink
Publikováno v:
Molecular Therapy. 20(9):1737-1749
The hepatitis C virus (HCV) chronically infects 2% of the world population and effective treatment is limited by long duration and significant side-effects. Here, we describe a novel drug, intended as a “single-shot ” therapy, which expresses thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30cf4df837f30b03fa37cdee33a8aa35
Autor:
Volker Turau, Bernd Hauck
Publikováno v:
Theoretical Computer Science. 412:5527-5540
The maximum weight matching problem is a fundamental problem in graph theory with a variety of important applications. Recently Manne and Mjelde presented the first self-stabilizing algorithm computing a 2-approximation of the optimal solution. They
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a199c5c29ae5d04dfdd53acb6fb0a38d
https://doi.org/10.1016/j.tcs.2010.11.032
https://doi.org/10.1016/j.tcs.2010.11.032
Autor:
Volker Turau, Bernd Hauck
Publikováno v:
Theoretical Computer Science. 412:4361-4371
The non-computability of many distributed tasks in anonymous networks is well known. This paper presents a deterministic self-stabilizing algorithm to compute a ( 3 − 2 Δ + 1 ) -approximation of a minimum vertex cover in anonymous networks. The al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32cf304268fd93922ba6ad5ae4b73ba0
https://doi.org/10.1016/j.tcs.2010.11.010
https://doi.org/10.1016/j.tcs.2010.11.010
Autor:
Volker Turau, Bernd Hauck
Publikováno v:
Information Processing Letters. 109:763-767
This paper presents a new distributed self-stabilizing algorithm for the weakly connected minimal dominating set problem. It assumes a self-stabilizing algorithm to compute a breadth-first tree. Using an unfair distributed scheduler the algorithm sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19dbcf685673c80c680df56b8bd8d7fa
https://doi.org/10.1016/j.ipl.2009.03.013
https://doi.org/10.1016/j.ipl.2009.03.013
Autor:
J. Fraser Wright, Harre D. Downey, Federico Mingozzi, Bernd Hauck, Patricia Favaro, Katherine A. High, Valder R. Arruda, J Shangzhen Zhou
Publikováno v:
Molecular Therapy. 17:1022-1030
The assessment of the risk of germline transmission of vector-coded sequences is critical for clinical translation of gene transfer strategies. We used rabbit models to analyze the risk of germline transmission of adeno-associated viral (AAV) vectors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba583fc97134968008357056292fd1e2
https://doi.org/10.1038/mt.2009.56
https://doi.org/10.1038/mt.2009.56
Autor:
Olga Zelenaia, Katherine A. High, Pete Smith, Guang Qu, Jurg M. Sommer, Xingge Liu, Federico Mingozzi, Samuel L. Murphy, J. Fraser Wright, Bernd Hauck
Publikováno v:
Molecular Therapy. 17:144-152
In a gene therapy clinical trial for hemophilia B, adeno-associated virus 2 (AAV2) capsid-specific CD8(+) T cells were previously implicated in the elimination of vector-transduced hepatocytes, resulting in loss of human factor IX (hFIX) transgene ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a12ed400c6d85b4c78db8a6c8047ffc
https://doi.org/10.1038/mt.2008.227
https://doi.org/10.1038/mt.2008.227
Autor:
Arkady Lyubarsky, Jean Bennett, Xiaosong Zhu, Maureen G. Maguire, Eric A. Pierce, Enrico Maria Surace, Kathleen A. Marshall, Barbara A. Konkle, Sandro Banfi, L. F. Dell'Osso, Jeannette L. Bennicelli, Jonathan B. Jacobs, Edwin M. Stone, J. Fraser Wright, Richard W. Hertle, Kenneth S. Shindler, Edward N. Pugh, Nicholas J. Volpe, Jennifer Wellman McDonnell, Katherine A. High, Junwei Sun, Valder R. Arruda, Francesco Testa, Albert M. Maguire, Jian Xing Ma, Alberto Auricchio, Federico Mingozzi, Bernd Hauck, Olga Zelenaia, T. Michael Redmond, Francesca Simonelli, Settimio Rossi
Publikováno v:
New England Journal of Medicine. 358:2240-2248
S um m a r y Leber's congenital amaurosis (LCA) is a group of inherited blinding diseases with onset during childhood. One form of the disease, LCA2, is caused by mutations in the retinal pigment epithelium-specific 65-kDa protein gene (RPE65). We in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bedee9d5016d2cd789444b7de1fd948
https://doi.org/10.1056/nejmoa0802315
https://doi.org/10.1056/nejmoa0802315
Autor:
Katherine A. High, Tonia S. Rex, Caroline J. Zeiss, J F Wright, Albert M. Maguire, Daniel Hui, L. F. Dell'Osso, Federico Mingozzi, Valder R. Arruda, Zhangyong Wei, Olga Zelenaia, Shangzhen Zhou, Jean Bennett, Gregory M. Acland, Bernd Hauck, Jeannette L. Bennicelli, Jonathan B. Jacobs, András M. Komáromy, Guang Qu, Daniel C. Chung
Publikováno v:
Molecular Therapy. 16(3):458-465
We evaluated the safety and efficacy of an optimized adeno-associated virus (AAV; AAV2.RPE65) in animal models of the RPE65 form of Leber congenital amaurosis (LCA). Protein expression was optimized by addition of a modified Kozak sequence at the tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f49eb472d28be99bd0eeefa6cf4d60d
Autor:
Pete Smith, Joseph Prado, Glenn F. Pierce, Floro Cataniag, Shangzhen Zhou, Katherine A. High, Alex Tai, Jac Luna, Jennifer Wellman McDonnell, J. Fraser Wright, Guang Qu, Jurg M. Sommer, Jingmin Zhou, Peter Colosi, Bernd Hauck, Jennifer Bahr-Davidson
Publikováno v:
Journal of Virological Methods. 140:183-192
Adeno-associated virus (AAV) empty capsids typically co-purify with genome containing AAV2 vectors purified by column chromatography. This study describes a method to remove empty capsids from genome containing vector particles by anion exchange chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1d912561265ebd70ac0de886cf63f4
https://doi.org/10.1016/j.jviromet.2006.11.019
https://doi.org/10.1016/j.jviromet.2006.11.019