Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Bernd Guilliard"'
Inhibition of uPA-uPAR signaling restores respiratory epithelial barrier function in asthma and COPD
Autor:
Tyler Hall, Megan J. Webster, Ingrid Christ, Matthias Hoffmann, Ines Kollak, David J. Lamb, Eva Peter, Victoria Schroeder, Jun Li, Neil Goeghagen, Frank Buettner, M.J. Thomas, Gisela Schnapp, James P. Garnett, Bernd Guilliard, Felix Schiele, Jennifer Schuett
Publikováno v:
Mechanisms of lung injury and repair.
In addition to uPA’s well-characterized role in fibrinolysis, recent publications have indicated a role for uPA-uPAR signaling in respiratory epithelia barrier function. Furthermore, uPA and uPAR expression/signaling are enhanced in severe asthmati
Autor:
Stefan Pflanz, Bernd Guilliard, Wioletta Skronska-Wasek, Felix Schiele, Wolfgang Rist, Kerstin Berer, Jochen Blender, James P. Garnett, Daniel Veyel
Publikováno v:
Airway Cell Biology and Immunopathology.
Chronic obstructive pulmonary disease (COPD) is characterized by emphysema, chronic inflammation and increased bacterial colonization of airways associated with exacerbations. While the number of macrophages is elevated in COPD, their phagocytic capa
Autor:
Mary Sanville-Ross, Melissa Canfield, Gerhard Schaenzle, Bernd Guilliard, Eva Wex, Daniel Bischoff, Sylvia Blum, Don Souza, Andreas Schnapp, Mark Panzenbeck, Mohammed A. Kashem, Helena Obernolte, Oliver Radmacher, Della White, Georg Rast, Gerd-Michael Maier, Jennifer L Swantek, Olga Danov, Stefan lutz Wollin, Hannah Haas, Christine Strasser, Armin Braun, Katherina Sewald, Thierry Bouyssou, Klaus J. Erb, Takeshi Kono, Eva Thaler, Helga Nickel, Matthias Hoffmann, David J. Lamb
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 357(3)
BI 1002494 [(R)-4-{(R)-1-[7-(3,4,5-trimethoxy-phenyl)-[1,6]napthyridin-5-yloxy]-ethyl}pyrrolidin-2-one] is a novel, potent, and selective spleen tyrosine kinase (SYK) inhibitor with sustained plasma exposure after oral administration in rats, which q
Autor:
Norbert Hauel, Ines Lauritsch, Bernd Guilliard, Andreas Schnapp, Iris Kauffmann, Joachim Lingner, Uwe M. Martens, Ulrike Hemmann, Christian Wenz, Barbara Enenkel, Claudia Niestroj, Wolfgang J. Rettig, Milena Pantic, Henning Priepke, Emanuelle Pascolo, Pilar Garin-Chesa, Norbert Kraut, Elfriede Müller, Gabriele Sauter, Klaus Damm, Christine Daiber
Publikováno v:
The EMBO Journal. 20:6958-6968
Telomerase, the ribonucleoprotein enzyme maintaining the telomeres of eukaryotic chromosomes, is active in most human cancers and in germline cells but, with few exceptions, not in normal human somatic tissues. Telomere maintenance is essential to th