Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Bernd Groner"'
Autor:
Vida Vafaizadeh, Bernd Groner, Boris Brill, Natalia Delis, Richard Moriggl, Corina Borghouts, Christian Brendel, Axel Weber
Publikováno v:
Pharmaceuticals, Vol 6, Iss 8, Pp 960-987 (2013)
The signal transducer and activator of transcription Stat5 is transiently activated by growth factor and cytokine signals in normal cells, but its persistent activation has been observed in a wide range of human tumors. Aberrant Stat5 activity was in
Externí odkaz:
https://doaj.org/article/90b771fd216f485f8c85940a24bd80e8
Autor:
Albrecht Piiper, Oliver Waidmann, Thomas J. Vogl, Stefan Zeuzem, Bernd Kronenberger, Horst-Werner Korf, Bernd Groner, Vida Vafaizadeh, Jose M. Arencibia, Ahmed Atef Ibrahim, Eduardo Alonso Augusto, Bianca Kakoschky, Thomas Pleli, Hüdayi Korkusuz, Verena Köberle, Christian Schmithals
Supplementary Figure S1: Imaging of HCC by Gd-EOB-DTPA-enhanced MRI in TGFα/c-myc mice with an HCC.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e2518fdb52432bfea9b32a7767af9d8
https://doi.org/10.1158/0008-5472.22405326.v1
https://doi.org/10.1158/0008-5472.22405326.v1
Autor:
Ines Breuksch, Boris Brill, Teresa Laguna, Oliver H. Krämer, Bernd Groner, Walburgis Brenner, Günter Schneider, Matthias Wirth, Cornelia Dietrich, Thorsten Heinzel, Falk Butter, Nicole Kiweler, Susanne Strand
Publikováno v:
Archives of toxicology. 92(7)
Novel therapies are required for the treatment of metastatic renal cell carcinoma (RCC), which is associated with inoperable disease and patient death. Histone deacetylases (HDACs) are epigenetic modifiers and potential drug targets. Additional infor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf139c75c7b1cd4c25dc8dd9b731437
https://pubmed.ncbi.nlm.nih.gov/29845424
https://pubmed.ncbi.nlm.nih.gov/29845424
Autor:
Christian Schmithals, Ahmed Atef Ibrahim, Stefan Zeuzem, Verena Köberle, Albrecht Piiper, Jose M. Arencibia, Thomas J. Vogl, Bianca Kakoschky, Vida Vafaizadeh, Bernd Kronenberger, Oliver Waidmann, Bernd Groner, Horst-Werner Korf, Eduardo Alonso Augusto, Thomas Pleli, H. Korkusuz
Publikováno v:
Cancer Research. 75:3147-3154
iRGD is a derivative of the integrin-binding peptide RGD, which selectively increases the penetrability of tumor tissue to various coadministered substances in several preclinical models. In this study, we investigated the ability of iRGD to improve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae3402d3833c7c11441d9c7a261899eb
https://doi.org/10.1158/0008-5472.can-15-0395
https://doi.org/10.1158/0008-5472.can-15-0395
Autor:
Natalia Delis, Corina Borghouts, Christian Brendel, Richard Moriggl, Bernd Groner, Vida Vafaizadeh, Boris Brill, Axel Weber
Publikováno v:
Cancers, Vol 7, Iss 1, Pp 503-537 (2015)
Cancers
Volume 7
Issue 1
Pages 503-537
Cancers
Volume 7
Issue 1
Pages 503-537
Signal transducers and activators of transcription (Stats) play central roles in the conversion of extracellular signals, e.g., cytokines, hormones and growth factors, into tissue and cell type specific gene expression patterns. In normal cells, thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae402e0f620ff86992ca206e00b3fe1
http://www.mdpi.com/2072-6694/7/1/503
http://www.mdpi.com/2072-6694/7/1/503
Publikováno v:
Analytical Biochemistry. 466:83-88
The presence of endotoxins in preparations of recombinantly produced therapeutic proteins poses serious problems for patients. Endotoxins can cause fever, respiratory distress syndromes, intravascular coagulation, or endotoxic shock. A number of meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e37ae801bc4ef7d94039a9d8419c24a7
https://doi.org/10.1016/j.ab.2014.08.020
https://doi.org/10.1016/j.ab.2014.08.020
Autor:
Viktoria von Manstein, Bernd Groner
Publikováno v:
Molecular and cellular endocrinology. 451
The effects of Jak Stat signaling and the persistent activation of Stat3 and Stat5 on tumor cell survival, proliferation and invasion have made the Jak Stat pathway a favorite target for drug development and cancer therapy. This notion was strengthen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e850bfc442d484465ad6b1957f5706
https://pubmed.ncbi.nlm.nih.gov/28576744
https://pubmed.ncbi.nlm.nih.gov/28576744
Autor:
Diane Richter, Chul Min Yang, Viktoria von Manstein, Vida Vafaizadeh, Bernd Groner, Natalia Delis
Publikováno v:
Current Signal Transduction Therapy
Scopus-Elsevier
Scopus-Elsevier
The emergence of low molecular weight kinase inhibitors as "targeted" drugs has led to remarkable advances in the treatment of cancer patients. The clinical benefits of these tumor therapies, however, vary widely in patient populations and with durat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8d98e43502b25c814da3181b82b810
https://doi.org/10.2174/1574362409666140206221931
https://doi.org/10.2174/1574362409666140206221931
Autor:
Bernd Groner, Vida Vafaizadeh
Publikováno v:
Molecular and Cellular Endocrinology. 382:552-559
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e9487d9aa7b369b25db5772cf276b6
https://doi.org/10.1016/j.mce.2013.08.019
https://doi.org/10.1016/j.mce.2013.08.019
Autor:
Bernd Groner, Nancy E. Hynes
Publikováno v:
PLoS Biology, Vol 14, Iss 9, p e2000314 (2016)
PLoS Biology
PLoS Biology
Cancer research has become a global enterprise, and the number of researchers, as well as the cost for their activities, has skyrocketed. The budget for the National Cancer Institute of the United States National Institutes of Health alone was US$5.2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c370b1cc7b43e8a99646f16257695af
http://europepmc.org/articles/PMC5042426?pdf=render
http://europepmc.org/articles/PMC5042426?pdf=render