Zobrazeno 1 - 10
of 203
pro vyhledávání: '"Bernd Groner"'
Autor:
Axel Weber, Corina Borghouts, Christian Brendel, Richard Moriggl, Natalia Delis, Boris Brill, Vida Vafaizadeh, Bernd Groner
Publikováno v:
Cancers, Vol 7, Iss 1, Pp 503-537 (2015)
Signal transducers and activators of transcription (Stats) play central roles in the conversion of extracellular signals, e.g., cytokines, hormones and growth factors, into tissue and cell type specific gene expression patterns. In normal cells, thei
Externí odkaz:
https://doaj.org/article/e964152be7d648e6b7cc01546e70628d
Autor:
Vida Vafaizadeh, Bernd Groner, Boris Brill, Natalia Delis, Richard Moriggl, Corina Borghouts, Christian Brendel, Axel Weber
Publikováno v:
Pharmaceuticals, Vol 6, Iss 8, Pp 960-987 (2013)
The signal transducer and activator of transcription Stat5 is transiently activated by growth factor and cytokine signals in normal cells, but its persistent activation has been observed in a wide range of human tumors. Aberrant Stat5 activity was in
Externí odkaz:
https://doaj.org/article/90b771fd216f485f8c85940a24bd80e8
Autor:
Albrecht Piiper, Oliver Waidmann, Thomas J. Vogl, Stefan Zeuzem, Bernd Kronenberger, Horst-Werner Korf, Bernd Groner, Vida Vafaizadeh, Jose M. Arencibia, Ahmed Atef Ibrahim, Eduardo Alonso Augusto, Bianca Kakoschky, Thomas Pleli, Hüdayi Korkusuz, Verena Köberle, Christian Schmithals
Supplementary Figure S3: Body weight of HepG2 (A) and Huh-7 (B) xenograft-bearing mice treated with iRGD, control (Ctl.) peptide, PBS and sorafenib (Sora).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162248249a6792df0df3f94c810a6ab0
https://doi.org/10.1158/0008-5472.22405320
https://doi.org/10.1158/0008-5472.22405320
Autor:
Ines Breuksch, Boris Brill, Teresa Laguna, Oliver H. Krämer, Bernd Groner, Walburgis Brenner, Günter Schneider, Matthias Wirth, Cornelia Dietrich, Thorsten Heinzel, Falk Butter, Nicole Kiweler, Susanne Strand
Publikováno v:
Archives of toxicology. 92(7)
Novel therapies are required for the treatment of metastatic renal cell carcinoma (RCC), which is associated with inoperable disease and patient death. Histone deacetylases (HDACs) are epigenetic modifiers and potential drug targets. Additional infor
Autor:
Christian Schmithals, Ahmed Atef Ibrahim, Stefan Zeuzem, Verena Köberle, Albrecht Piiper, Jose M. Arencibia, Thomas J. Vogl, Bianca Kakoschky, Vida Vafaizadeh, Bernd Kronenberger, Oliver Waidmann, Bernd Groner, Horst-Werner Korf, Eduardo Alonso Augusto, Thomas Pleli, H. Korkusuz
Publikováno v:
Cancer Research. 75:3147-3154
iRGD is a derivative of the integrin-binding peptide RGD, which selectively increases the penetrability of tumor tissue to various coadministered substances in several preclinical models. In this study, we investigated the ability of iRGD to improve
Autor:
Natalia Delis, Corina Borghouts, Christian Brendel, Richard Moriggl, Bernd Groner, Vida Vafaizadeh, Boris Brill, Axel Weber
Publikováno v:
Cancers, Vol 7, Iss 1, Pp 503-537 (2015)
Cancers
Volume 7
Issue 1
Pages 503-537
Cancers
Volume 7
Issue 1
Pages 503-537
Signal transducers and activators of transcription (Stats) play central roles in the conversion of extracellular signals, e.g., cytokines, hormones and growth factors, into tissue and cell type specific gene expression patterns. In normal cells, thei
Publikováno v:
Analytical Biochemistry. 466:83-88
The presence of endotoxins in preparations of recombinantly produced therapeutic proteins poses serious problems for patients. Endotoxins can cause fever, respiratory distress syndromes, intravascular coagulation, or endotoxic shock. A number of meth
Autor:
Viktoria von Manstein, Bernd Groner
Publikováno v:
Molecular and cellular endocrinology. 451
The effects of Jak Stat signaling and the persistent activation of Stat3 and Stat5 on tumor cell survival, proliferation and invasion have made the Jak Stat pathway a favorite target for drug development and cancer therapy. This notion was strengthen
Autor:
Diane Richter, Chul Min Yang, Viktoria von Manstein, Vida Vafaizadeh, Bernd Groner, Natalia Delis
Publikováno v:
Current Signal Transduction Therapy
Scopus-Elsevier
Scopus-Elsevier
The emergence of low molecular weight kinase inhibitors as "targeted" drugs has led to remarkable advances in the treatment of cancer patients. The clinical benefits of these tumor therapies, however, vary widely in patient populations and with durat
Autor:
Bernd Groner, Vida Vafaizadeh
Publikováno v:
Molecular and Cellular Endocrinology. 382:552-559