Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Bernd Bollinger"'
Publikováno v:
Synthesis. 2001:2281-2288
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baed6aa35c5bbf4b59cb05bd984b7802
https://doi.org/10.1055/s-2001-18445
https://doi.org/10.1055/s-2001-18445
Autor:
Bernd Bollinger, Dale L. Boger, Qing Jin, Donald L. Hertzog, Paul A. Kitos, Hui Cai, Douglas S. Johnson, Robert M. Garbaccio, Philippe Mesini
Publikováno v:
Journal of the American Chemical Society. 119:4987-4998
The synthesis and examination of two unique classes of duocarmycin SA analogs are described which we refer to as reversed and sandwiched analogs. Their examination established both the origin of the DNA alkylation selectivity and that both enantiomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca118822aed4c348debe4ee4a6424ca5
https://doi.org/10.1021/ja9637210
https://doi.org/10.1021/ja9637210
Autor:
Hui Cai, Bernd Bollinger, Douglas S. Johnson, Joel Adam Goldberg, Donald L. Hertzog, Philip Turnbull, Dale L. Boger
Publikováno v:
Journal of the American Chemical Society. 119:4977-4986
The examination of shortened, simplified, and extended analogs of duocarmycin SA is described and constitutes a detailed study of the role of linked DNA binding subunit. In addition to enhancing the DNA binding affinity and selectivity through minor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c65adfc11b85c37338bd8cbadb2ccb6f
https://doi.org/10.1021/ja9637208
https://doi.org/10.1021/ja9637208
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2207-2210
The preparation and examination of 4–7 revealed that (+)- 5 and (+)-duocarmycin SA were indistinguishable. In contrast, 6 and 7 exhibited properties more analogous to 4 illustrating that the C6 and C7 methoxy substituents of duocarmycin SA contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da2d2c501b2d5a7261140bd1cd048263
https://doi.org/10.1016/0960-894x(96)00401-5
https://doi.org/10.1016/0960-894x(96)00401-5
Publikováno v:
Archiv der Pharmazie. 328:609-614
The novel aminobenzindolone 8 was prepared and evaluated as a potential antipsychotic agent. The target compound was synthesized in eight steps starting from the tetrahydrobenzindolone 9. The key step of the synthesis was an electrophilic amination o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba80f40cb39165f8a4f04505ede77cd
https://doi.org/10.1002/ardp.19953280708
https://doi.org/10.1002/ardp.19953280708
Autor:
Bernd Bollinger, Peter Gmeiner
Publikováno v:
Tetrahedron. 50:10909-10922
An effective synthesis of β-aminotetralins ( 6 ) including an asymmetric electrophilic amination by di-t-butyl azodicarboxylate is reported. Depending on the chiral auxiliaries (S) - 7a-d , the central intermediates 9 and 10 could be isolated in 62
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36953fccd0d5b6b7034e3bb34ccb5428
https://doi.org/10.1016/s0040-4020(01)85702-1
https://doi.org/10.1016/s0040-4020(01)85702-1
Publikováno v:
ChemInform. 28
The preparation and examination of 4–7 revealed that (+)- 5 and (+)-duocarmycin SA were indistinguishable. In contrast, 6 and 7 exhibited properties more analogous to 4 illustrating that the C6 and C7 methoxy substituents of duocarmycin SA contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bde650d3ba210beeb2a2758045dd224
https://doi.org/10.1002/chin.199703294
https://doi.org/10.1002/chin.199703294
Autor:
Bernd Bollinger, Peter Gmeiner
Publikováno v:
ChemInform. 23
A mild and efficient method for the construction of β-aryl amines from the corresponding α-aryl ketones is presented. The key steps of the synthesis involve an electrophilic amination by dibenzyl azodicarboxylate followed by a stereoselective LiHBE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b46521694985ee619ce690885fbf07e
https://doi.org/10.1002/chin.199227158
https://doi.org/10.1002/chin.199227158
Autor:
Peter Gmeiner, Bernd Bollinger
Publikováno v:
ChemInform. 26
An effective synthesis of β-aminotetralins ( 6 ) including an asymmetric electrophilic amination by di-t-butyl azodicarboxylate is reported. Depending on the chiral auxiliaries (S) - 7a-d , the central intermediates 9 and 10 could be isolated in 62
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32d7f372538a1f48d87155449a4c80b6
https://doi.org/10.1002/chin.199508075
https://doi.org/10.1002/chin.199508075
Autor:
Bernd Bollinger, Peter Gmeiner
Publikováno v:
ChemInform. 26
We have recently communicated the synthesis of the tricyclic lactam 1, which is currently being investigated for its activity as an atypical neuroleptic, from the commercially available tetrahydrobenzindolinone 3a (Scheme 1).7 During this synthesis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::975d03f2d4d3853c7a67474fec9e2244
https://doi.org/10.1002/chin.199532104
https://doi.org/10.1002/chin.199532104