Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Bernd Bohrmann"'
Autor:
Esther Melo, Philipp Oertle, Carolyn Trepp, Hélène Meistermann, Thomas Burgoyne, Lorenzo Sborgi, Alvaro Cortes Cabrera, Chia-yi Chen, Jean-Christophe Hoflack, Tony Kam-Thong, Roland Schmucki, Laura Badi, Nicholas Flint, Zeynep Eren Ghiani, Fréderic Delobel, Corinne Stucki, Giulia Gromo, Alfred Einhaus, Benoit Hornsperger, Sabrina Golling, Juliane Siebourg-Polster, Francoise Gerber, Bernd Bohrmann, Clare Futter, Tom Dunkley, Sebastian Hiller, Oliver Schilling, Volker Enzmann, Sascha Fauser, Marija Plodinec, Roberto Iacone
Publikováno v:
EBioMedicine, Vol 27, Iss C, Pp 258-274 (2018)
Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss. The protein HtrA1 is enriched in retinal pigment epithelial (RPE) cells isolated from AMD patients and in drusen deposits. However, it is poorly understood how i
Externí odkaz:
https://doaj.org/article/98697e83512f42e8992a6dee356485cc
Autor:
Felix Weber, Bernd Bohrmann, Jens Niewoehner, Jens A.A. Fischer, Petra Rueger, Georg Tiefenthaler, Joerg Moelleken, Alexander Bujotzek, Kevin Brady, Thomas Singer, Martin Ebeling, Antonio Iglesias, Per-Ola Freskgård
Publikováno v:
Cell Reports, Vol 22, Iss 1, Pp 149-162 (2018)
Summary: Receptors show promise for the transport of monoclonal antibodies (mAbs) across the blood-brain barrier. However, safety liabilities associated with peripheral receptor binding and Fc effector function have been reported. We present the Brai
Externí odkaz:
https://doaj.org/article/cfcea31f527746b2b77e3b13637c56eb
Autor:
Xianyuan Xiang, Georg Werner, Bernd Bohrmann, Arthur Liesz, Fargol Mazaheri, Anja Capell, Regina Feederle, Irene Knuesel, Gernot Kleinberger, Christian Haass
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 9, Pp 992-1004 (2016)
Abstract Immunotherapeutic approaches are currently the most advanced treatments for Alzheimer's disease (AD). Antibodies against amyloid β‐peptide (Aβ) bind to amyloid plaques and induce their clearance by microglia via Fc receptor‐mediated ph
Externí odkaz:
https://doaj.org/article/60a18367797547b292471ddc3fc25353
Autor:
Fiona Grueninger, Bernd Bohrmann, Christian Czech, Theresa Maria Ballard, Johann R. Frey, Claudia Weidensteiner, Markus von Kienlin, Laurence Ozmen
Publikováno v:
Neurobiology of Disease, Vol 37, Iss 2, Pp 294-306 (2010)
Amyloid beta peptides and microtubule-associated protein Tau are misfolded and form aggregates in brains of Alzheimer's disease patients. To examine their specific roles in the pathogenesis of Alzheimer's disease and their relevance in neurodegenerat
Externí odkaz:
https://doaj.org/article/835f463d371247e9b7158af9ab0ff330
Autor:
Alessio Colombo, Bart De Strooper, Laura Sebastian Monasor, Fatemeharefeh Nami, Sarah Schouteden, Mark Fiers, Bernd Bohrmann, Ruben Boon, Laura Ordovás, Johanna Van Daele, Christel Claes, Catherine M. Verfaillie, Sabina Tahirovic
Publikováno v:
Alzheimer's and dementia 15(3), 453-464 (2019). doi:10.1016/j.jalz.2018.09.006
INTRODUCTION: Murine microglia expressing the Alzheimer's disease-linked TREM2R47H mutation display variable decrease in phagocytosis, while impaired phagocytosis is reported following loss of TREM2. However, no data exist on TREM2+/R47H human microg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d642a9628027c40cffc67cd3c38b23
https://doi.org/10.1016/j.jalz.2018.09.006
https://doi.org/10.1016/j.jalz.2018.09.006
Autor:
Michael Willem, Tanja Blume, Bernd Bohrmann, Peter Bartenstein, Matthias Brendel, Axel Rominger, Christian Haass, Franz-Josef Gildehaus, Federico Probst, Anna Jaworska, Felix Overhoff, Jochen Herms
Publikováno v:
Theranostics 8(18), 4957-4968 (2018). doi:10.7150/thno.27868
Brendel, Matthias; Jaworska, Anna; Overhoff, Felix; Blume, Tanja; Probst, Federico; Gildehaus, Franz-Josef; Bartenstein, Peter; Haass, Christian; Bohrmann, Bernd; Herms, Jochen; Willem, Michael; Rominger, Axel (2018). Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation. Theranostics, 8(18), pp. 4957-4968. Ivyspring International 10.7150/thno.27868
Theranostics
Brendel, Matthias; Jaworska, Anna; Overhoff, Felix; Blume, Tanja; Probst, Federico; Gildehaus, Franz-Josef; Bartenstein, Peter; Haass, Christian; Bohrmann, Bernd; Herms, Jochen; Willem, Michael; Rominger, Axel (2018). Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation. Theranostics, 8(18), pp. 4957-4968. Ivyspring International 10.7150/thno.27868
Theranostics
Beta secretase (BACE) inhibitors are promising therapeutic compounds currently in clinical phase II/III trials. Preclinical [18F]-florbetaben (FBB) amyloid PET imaging facilitates longitudinal monitoring of amyloidosis in Alzheimer's disease (AD) mou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f8d9702dd54d356f06da024b7bdae3
https://doi.org/10.7150/thno.27868
https://doi.org/10.7150/thno.27868
Autor:
Christine Schubert, Loris Villabruna, Wolfgang F. Richter, Alan M. Hoberman, Paul Barrow, Bernd Bohrmann
Publikováno v:
Reproductive Toxicology. 73:362-371
Gantenerumab is intended for the treatment of Alzheimer's disease. It is a fully human recombinant monoclonal IgG1 which binds aggregated forms of amyloid beta such as Aβ oligomers, fibrils and neuritic amyloid plaques. A full package of development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e0c8d039d5403b8d63c9730f040501
https://doi.org/10.1016/j.reprotox.2017.07.014
https://doi.org/10.1016/j.reprotox.2017.07.014
Autor:
Paula P Navarro, Amanda J Lewis, Tim Moors, Jürgen Hench, Wilma D.J. van de Berg, Jing Wang, Vincenzo Bonifati, Andreas Staempfli, Markus Britschgi, Annemieke J.M. Rozemuller, Frederik Großerüschkamp, Henning Stahlberg, Stephan Frank, Evelien Huisman, Klaus Gerwert, Daniel Niedieker, Wilfred F. J. van IJcken, Yvonne de Gier, Rosmarie Sütterlin, Gabriel Schweighauser, Angela Ingrassia, Kenneth N. Goldie, Joerg Hoernschemeyer, Anne De Paepe, Sarah H Shahmoradian, Matthias E. Lauer, Johannes Erny, Alexandra Graff-Meyer, Christel Genoud, Marialuisa Quadri, Bernd Bohrmann, Daniel Castaño-Díez, Samir F. El-Mashtoly
Publikováno v:
Shahmoradian, S H, Lewis, A J, Genoud, C, Hench, J R, Moors, T E, Navarro, P P, Castaño-Díez, D, Schweighauser, G, Graff-Meyer, A, Goldie, K N, Sütterlin, R, Huisman, E, Ingrassia, A, Gier, Y D, Rozemuller, A J M, Wang, J, Paepe, A D, Erny, J, Staempfli, A, Hoernschemeyer, J, Großerüschkamp, F, Niedieker, D, el-Mashtoly, S F, Quadri, M, van IJcken, W F J, Bonifati, V, Gerwert, K, Bohrmann, B, Frank, S, Britschgi, M, Stahlberg, H, van de Berg, W D J & Lauer, M E 2019, ' Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes ', Nature Neuroscience, vol. 22, no. 7, pp. 1099-1109 . https://doi.org/10.1038/s41593-019-0423-2
Nature Neuroscience, 22(7), 1099-+. Nature Publishing Group
Nature Neuroscience, 22(7), 1099-1109. Nature Publishing Group
Nature Neuroscience, 22(7), 1099-+. Nature Publishing Group
Nature Neuroscience, 22(7), 1099-1109. Nature Publishing Group
Parkinson's disease, the most common age-related movement disorder, is a progressive neurodegenerative disease with unclear etiology. Key neuropathological hallmarks are Lewy bodies and Lewy neurites: neuronal inclusions immunopositive for the protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b1dc002c6518905c4185595a0f3b06
https://research.vumc.nl/en/publications/06f8f039-13aa-44ee-a512-b049e4ba1194
https://research.vumc.nl/en/publications/06f8f039-13aa-44ee-a512-b049e4ba1194
Autor:
Paula P Navarro, Alexandra Graff-Meyer, Jürgen Hench, Matthias E. Lauer, Bernd Bohrmann, Yvonne de Gier, Gabriel Schweighauser, Annemieke J.M. Rozemuller, Henning Stahlberg, Stephan Frank, Christel Genoud, Daniel Castaño-Díez, Sarah H Shahmoradian, Markus Britschgi, Amanda J Lewis, Wilma D.J. van de Berg
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports, 8(1):18046. Nature Publishing Group
Navarro, P P, Genoud, C, Castaño-Díez, D, Graff-Meyer, A, Lewis, A J, de Gier, Y, Lauer, M E, Britschgi, M, Bohrmann, B, Frank, S, Hench, J, Schweighauser, G, Rozemuller, A J M, van de Berg, W D J, Stahlberg, H & Shahmoradian, S H 2018, ' Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles ', Scientific Reports, vol. 8, no. 1, 18046 . https://doi.org/10.1038/s41598-018-36223-4
Scientific Reports
Scientific Reports, 8(1):18046. Nature Publishing Group
Navarro, P P, Genoud, C, Castaño-Díez, D, Graff-Meyer, A, Lewis, A J, de Gier, Y, Lauer, M E, Britschgi, M, Bohrmann, B, Frank, S, Hench, J, Schweighauser, G, Rozemuller, A J M, van de Berg, W D J, Stahlberg, H & Shahmoradian, S H 2018, ' Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles ', Scientific Reports, vol. 8, no. 1, 18046 . https://doi.org/10.1038/s41598-018-36223-4
Scientific Reports
Corpora amylacea are cell-derived structures that appear physiologically in the aged human brain. While their histological identification is straightforward, their ultrastructural composition and microenvironment at the nanoscale have remained unclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08baecb2f44e52a8f9ff3b11bfb1702c
https://doi.org/10.1038/s41598-018-36223-4
https://doi.org/10.1038/s41598-018-36223-4
Autor:
Juliane Siebourg-Polster, Volker Enzmann, Laura Badi, Jean-Christophe Hoflack, Tony Kam-Thong, Esther Melo, Giulia Gromo, Zeynep Eren Ghiani, Alvaro Cortes Cabrera, Roberto Iacone, Sascha Fauser, Benoit Hornsperger, Sebastian Hiller, Thomas Burgoyne, Francoise Gerber, Lorenzo Sborgi, Sabrina Golling, Nicholas Flint, Chia-yi Chen, Marija Plodinec, Roland Schmucki, Hélène Meistermann, Alfred Einhaus, Oliver Schilling, Philipp Oertle, Clare E. Futter, Frederic Delobel, Carolyn Trepp, Tom Dunkley, Corinne Stucki, Bernd Bohrmann
Publikováno v:
EBioMedicine
EBioMedicine, Vol 27, Iss C, Pp 258-274 (2018)
Melo, Esther; Oertle, Philipp; Trepp, Carolyn Mary; Meistermann, Hélène; Burgoyne, Thomas; Sborgi, Lorenzo; Cabrera, Alvaro Cortes; Chen, Chia-Yi; Hoflack, Jean-Christophe; Kam-Thong, Tony; Schmucki, Roland; Badi, Laura; Flint, Nicholas; Ghiani, Zeynep Eren; Delobel, Fréderic; Stucki, Corinne; Gromo, Giulia; Einhaus, Alfred; Hornsperger, Benoit; Golling, Sabrina; ... (2018). HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model. EBioMedicine, 27, pp. 258-274. Elsevier 10.1016/j.ebiom.2017.12.011
EBioMedicine, Vol 27, Iss C, Pp 258-274 (2018)
Melo, Esther; Oertle, Philipp; Trepp, Carolyn Mary; Meistermann, Hélène; Burgoyne, Thomas; Sborgi, Lorenzo; Cabrera, Alvaro Cortes; Chen, Chia-Yi; Hoflack, Jean-Christophe; Kam-Thong, Tony; Schmucki, Roland; Badi, Laura; Flint, Nicholas; Ghiani, Zeynep Eren; Delobel, Fréderic; Stucki, Corinne; Gromo, Giulia; Einhaus, Alfred; Hornsperger, Benoit; Golling, Sabrina; ... (2018). HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model. EBioMedicine, 27, pp. 258-274. Elsevier 10.1016/j.ebiom.2017.12.011
Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss. The protein HtrA1 is enriched in retinal pigment epithelial (RPE) cells isolated from AMD patients and in drusen deposits. However, it is poorly understood how i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e980298c37719f2e698c7daab9b7e6b