Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Bernd Altmann"'
Autor:
Maria Cristina de Vera Mudry, Franziska Regenass-Lechner, Laurence Ozmen, Bernd Altmann, Matthias Festag, Thomas Singer, Lutz Müller, Helmut Jacobsen, Alexander Flohr
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2012 (2012)
The γ-secretase complex is a promising target in Alzheimer’s disease because of its role in the amyloidogenic processing of β-amyloid precursor protein. This enzyme also catalyzes the cleavage of Notch receptor, resulting in the nuclear transloca
Externí odkaz:
https://doaj.org/article/f41c8172e1c04018ae107b1352a5fda6
Autor:
Nicole Wyttenbach, Michael J. Mihatsch, Bernd Steinhuber, Urs Niederhauser, Holger Fischer, Barbara Lenz, Bernd Altmann, Andreas Brink
Publikováno v:
Toxicological Sciences
Poor solubility of drug candidates mainly affects bioavailability, but poor solubility of drugs and metabolites can also lead to precipitation within tissues, particularly when high doses are tested. RO0728617 is an amphoteric compound bearing basic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da3a3aad817087b26128cffc6cb9b32
http://europepmc.org/articles/PMC8041455
http://europepmc.org/articles/PMC8041455
Autor:
Elke-Astrid Atzpodien, Bernd Altmann, Simon A. Pot, Barbara Lenz, Solveig Badillo, Petr Soukup
Publikováno v:
Journal of pharmacological and toxicological methods. 104
Introduction Confocal scanning laser ophthalmoscopy and optical coherence tomography (cSLO-OCT) became available for human and animal ophthalmic examinations in recent years. The purpose of this study was to evaluate lesion detection and localization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3dd8c11f56893a618ae96bca9a2f21
https://pubmed.ncbi.nlm.nih.gov/32413488
https://pubmed.ncbi.nlm.nih.gov/32413488
Publikováno v:
Safety and Reliability – Theory and Applications.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d81751fa5bc8ea524f2518c19dc033c
https://doi.org/10.1201/9781315210469-430
https://doi.org/10.1201/9781315210469-430
Interspecies Variation of Outer Retina and Choriocapillaris Imaged With Optical Coherence Tomography
Autor:
Peter Maloca, Matthias Festag, Bernd Altmann, Elke-Astrid Atzpodien, Simon A. Pot, Petr Soukup
Publikováno v:
Investigative Opthalmology & Visual Science. 60:3332
Purpose The purpose of this study is to assess with spectral-domain optical coherence tomography (OCT) the interspecies variation of outer retinal morphology and identification of choriocapillaris in four research animal species. Methods Spectralis H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5341c4fb28f5e717648714d183134d9f
https://doi.org/10.1167/iovs.18-26257
https://doi.org/10.1167/iovs.18-26257
Autor:
Elke-Astrid Atzpodien, Pascal W. Hasler, Peter Maloca, Manuel A. Silva Munoz, Thomas Singer, Cyrill Gyger, Juergen Funk, Bjoern Jacobsen, Bernd Altmann
Publikováno v:
Toxicologic pathology. 44(3)
There is increased interest to use minipigs in ocular toxicology studies due to their anatomical similarities with human eyes and as a substitute for nonhuman primates. This requires adaptation of enhanced optical coherence tomography (OCT) technique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf3652f6dfb4775c508c6958303fb8d
https://pubmed.ncbi.nlm.nih.gov/26680760
https://pubmed.ncbi.nlm.nih.gov/26680760
Autor:
Kevin Brady, Barbara Lenz, Niels Fisker, Michael J. Mihatsch, Bernd Altmann, Mudher Albassam, Georg Schmitt, Thomas Singer, Kamille Dumong Erichsen, Susanne Mohr, Thomas Weiser, Juergen Funk, Marco Berrera, Corinne Ploix, Franz Schuler, Robert Persson, Yann Tessier, Matthias Festag, Rainer Constien, Annamaria Braendli-Baiocco
Publikováno v:
Toxicological Sciences. :kfx025
Non-human primates (NHPs) are currently considered to be the non-rodent species of choice for the preclinical safety assessment of single-stranded oligonucleotide (SSO) drugs. We evaluated minipigs as a potential alternative to NHPs to test the safet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8772aabe1a422600b8541159104e2f7b
https://doi.org/10.1093/toxsci/kfx025
https://doi.org/10.1093/toxsci/kfx025
Autor:
Bernd Altmann, Jürgen Funk, Andreas Pospischil, Francois Christen, Thomas Singer, Daniela Alberati, Georg Schmitt, Annette Körner, Michael Winter
Publikováno v:
Experimental Hematology. 44:964-974.e4
Glycine is a key rate-limiting component of heme biosynthesis in erythropoietic cells, where the high intracellular glycine demand is primarily supplied by the glycine transporter 1 (GlyT1). The impact of intracellular glycine restriction after GlyT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c625bd74d3fbec6616b15e492339f2
https://doi.org/10.1016/j.exphem.2016.07.003
https://doi.org/10.1016/j.exphem.2016.07.003
Publikováno v:
International Journal of Satellite Communications. 9:51-63
This paper describes the construction of the control centre for the satellites DFS Kopernikus and TVSAT of the German PTT Administration (DBP Telekom), with emphasis on the implemented technical solutions for monitoring and control. The space and gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93a593255ff32f2e775cda65abf6d4a0
https://doi.org/10.1002/sat.4600090202
https://doi.org/10.1002/sat.4600090202
Publikováno v:
Lecture Notes in Computer Science ISBN: 9783540665311
DISC
DISC
This paper introduces a new adversary model for Byzantine agreement and broadcast among a set P of players in which the adversary may perform two different types of player corruption: active (Byzantine) corruption and fail-corruption (crash). As a st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b40c18558627cbe26638ad9254c57d68
https://doi.org/10.1007/3-540-48169-9_9
https://doi.org/10.1007/3-540-48169-9_9
