Zobrazeno 1 - 10
of 472
pro vyhledávání: '"Bernd, Wullich"'
Autor:
August Fiegl, Olaf Wendler, Johannes Giedl, Nadine T. Gaisa, Georg Richter, Valentina Campean, Maximilian Burger, Femke Simmer, Iris Nagtegaal, Bernd Wullich, Simone Bertz, Arndt Hartmann, Robert Stoehr
Publikováno v:
Current Oncology, Vol 31, Iss 10, Pp 5752-5761 (2024)
Penile squamous cell carcinoma (pSCC) is a rare malignancy with a global incidence ranging from 0.1 to 0.7 per 100,000 males. Prognosis is generally favorable for localized tumors, but metastatic pSCC remains challenging, with low survival rates. The
Externí odkaz:
https://doaj.org/article/14907560a88b43e28cf14c2e4cc6ef12
Autor:
Annalena Branz, Christian Matek, Fabienne Lange, Veronika Bahlinger, Niklas Klümper, Michael Hölzel, Pamela L. Strissel, Reiner Strick, Danijel Sikic, Sven Wach, Helge Taubert, Bernd Wullich, Arndt Hartmann, Barbara Seliger, Markus Eckstein
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionUrothelial bladder cancer is frequent and exhibits diverse prognoses influenced by molecular subtypes, urothelial subtype histology, and immune microenvironments. HLA-G, known for immune regulation, displays significant membranous express
Externí odkaz:
https://doaj.org/article/9a3359d7262e4505b637932af7440aae
Autor:
Juan Guzman, Katrin Weigelt, Angela Neumann, Philipp Tripal, Benjamin Schmid, Zoltán Winter, Ralph Palmisano, Zoran Culig, Marcus V. Cronauer, Paul Muschler, Bernd Wullich, Helge Taubert, Sven Wach
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background The androgen/androgen receptor (AR)-signaling axis plays a central role in prostate cancer (PCa). Upon androgen-binding the AR dimerizes with another AR, and translocates into the nucleus where the AR-dimer activates/inactivates a
Externí odkaz:
https://doaj.org/article/540315149f484863b24ccb2561a69445
Autor:
Miriam Angeloni, Thomas vanDoeveren, Sebastian Lindner, Patrick Volland, Jorina Schmelmer, Sebastian Foersch, Christian Matek, Robert Stoehr, Carol I Geppert, Hendrik Heers, Sven Wach, Helge Taubert, Danijel Sikic, Bernd Wullich, Geert JLH vanLeenders, Vasily Zaburdaev, Markus Eckstein, Arndt Hartmann, Joost L Boormans, Fulvia Ferrazzi, Veronika Bahlinger
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 10, Iss 2, Pp n/a-n/a (2024)
Abstract Upper tract urothelial carcinoma (UTUC) is a rare and aggressive, yet understudied, urothelial carcinoma (UC). The more frequent UC of the bladder comprises several molecular subtypes, associated with different targeted therapies and overlap
Externí odkaz:
https://doaj.org/article/ea49233d91ae4f1c9eec6b27ab16c36c
Autor:
Niklas Klümper, Lennert Wüst, Jonas Saal, Damian J. Ralser, Romina Zarbl, Jonas Jarczyk, Johannes Breyer, Danijel Sikic, Bernd Wullich, Christian Bolenz, Florian Roghmann, Michael Hölzel, Manuel Ritter, Sebastian Strieth, Arndt Hartmann, Philipp Erben, Ralph M. Wirtz, Jennifer Landsberg, Dimo Dietrich, Markus Eckstein
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTPD-L1 status assessed by immunohistochemistry (IHC) has failed to reliably predict outcomes for patients with metastatic urothelial carcinoma (mUC) on immune checkpoint blockade (ICB). PD-L1 promoter methylation is an epigenetic mechanism tha
Externí odkaz:
https://doaj.org/article/db84a83835784401bcaeca4a8df3487d
Autor:
Stefanie Zschäbitz, Marie Mikuteit, Christine Stöhr, Edwin Herrmann, Iris Polifka, Abbas Agaimy, Lutz Trojan, Philipp Ströbel, Frank Becker, Christian Wülfing, Peter Barth, Michael Stöckle, Michael Staehler, Christian Stief, Axel Haferkamp, Markus Hohenfellner, Stefan Duensing, Stephan Macher-Göppinger, Bernd Wullich, Joachim Noldus, Walburgis Brenner, Frederik C. Roos, Bernhard Walter, Wolfgang Otto, Maximilian Burger, Andres Jan Schrader, Arndt Hartmann, Franziska Erlmeier, Sandra Steffens
Publikováno v:
Discover Oncology, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract Background Nectin-4 contributes to tumor proliferation, lymphangiogenesis and angiogenesis in malignant tumors and is an emerging target in tumor therapy. In renal cell carcinoma (RCC) VEGF-directed tyrosine kinase inhibitors and checkpoint
Externí odkaz:
https://doaj.org/article/f48c4647fe714704ac7639eb9dc60db9
Autor:
Carla E. Schulmeyer, Matthias W. Beckmann, Peter A. Fasching, Lothar Häberle, Henriette Golcher, Frank Kunath, Bernd Wullich, Julius Emons
Publikováno v:
Diagnostics, Vol 13, Iss 21, p 3300 (2023)
Background: To improve the quality and cost-effectiveness of care, cancer patients can obtain a second medical opinion on their treatment. Validation of the diagnostic procedure (e.g., imaging), diagnosis, and treatment recommendation allows oncologi
Externí odkaz:
https://doaj.org/article/fd25005eab2847c891f6e8ee4f402910
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
PurposeTo investigate whether a two-stage repair of distal- and mid-shaft hypospadias (non-proximal hypospadias) could eliminate the risk factors resulting from adverse urethral plate characteristics and eventually reduce complication rates.MethodsWe
Externí odkaz:
https://doaj.org/article/9f90f26f77cd497b98fa60556bdb84cb
Autor:
Michael Friedrich, Christine Stoehr, Simon Jasinski-Bergner, Arndt Hartmann, Sven Wach, Bernd Wullich, André Steven, Barbara Seliger
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-11 (2020)
Abstract Background The non-classical human leukocyte antigen (HLA)-G is a strong immunomodulatory molecule. Under physiological conditions, HLA-G induces immunological tolerance in immune privileged tissues, while under pathophysiological situations
Externí odkaz:
https://doaj.org/article/7db6c0a4e8964cb5bbad5f10158ab1b6
Autor:
Verena Lieb, Amer Abdulrahman, Katrin Weigelt, Siegfried Hauch, Michael Gombert, Juan Guzman, Laura Bellut, Peter J. Goebell, Robert Stöhr, Arndt Hartmann, Bernd Wullich, Helge Taubert, Sven Wach
Publikováno v:
Cells, Vol 11, Iss 22, p 3618 (2022)
In the present study, we further analyzed the data obtained in our previous study, where we investigated the cell-free DNA (cfDNA) of 34 progressive prostate cancer patients via targeted sequencing. Here, we studied the occurrence and prognostic impa
Externí odkaz:
https://doaj.org/article/d3c19022b16c462592f34db814de2119