A Protocol to Investigate Deep Brain Stimulation for Refractory Tinnitus: From Rat Model to the Set-Up of a Human Pilot Study

Autor: Gusta van Zwieten, Jana V. P. Devos, Sonja A. Kotz, Linda Ackermans, Pia Brinkmann, Lobke Dauven, Erwin L. J. George, A. Miranda L. Janssen, Bernd Kremer, Carsten Leue, Michael Schwartze, Yasin Temel, Jasper V. Smit, Marcus L. F. Janssen

Publikováno v: Audiology Research, Vol 13, Iss 1, Pp 49-63 (2022)

Background: Chronic tinnitus can have an immense impact on quality of life. Despite recent treatment advances, many tinnitus patients remain refractory to them. Preclinical and clinical evidence suggests that deep brain stimulation (DBS) is a promisi

Externí odkaz: https://doaj.org/article/8686bbd27d434d6db134acea9d62b6ac

Presence of Human Papillomavirus and Epstein–Barr Virus, but Absence of Merkel Cell Polyomavirus, in Head and Neck Cancer of Non-Smokers and Non-Drinkers

Autor: Frans J. Mulder, Faisal Klufah, Famke M. E. Janssen, Farzaneh Farshadpour, Stefan M. Willems, Remco de Bree, Axel zur Hausen, Mari F. C. M. van den Hout, Bernd Kremer, Ernst-Jan M. Speel

Publikováno v: Frontiers in Oncology, Vol 10 (2021)

ObjectiveDetermine the presence and prognostic value of human papillomavirus (HPV), Epstein-Barr virus (EBV), Merkel cell polyomavirus (MCPyV), and cell cycle proteins in head and neck squamous cell carcinoma (HNSCC) of non-smokers and non-drinkers (

Externí odkaz: https://doaj.org/article/3d3cccc3978f4fb58aad279148b03514

Ex Vivo Culture Models to Indicate Therapy Response in Head and Neck Squamous Cell Carcinoma

Autor: Imke Demers, Johan Donkers, Bernd Kremer, Ernst Jan Speel

Publikováno v: Cells, Vol 9, Iss 11, p 2527 (2020)

Head and neck squamous cell carcinoma (HNSCC) is characterized by a poor 5 year survival and varying response rates to both standard-of-care and new treatments. Despite advances in medicine and treatment methods, mortality rates have hardly decreased

Externí odkaz: https://doaj.org/article/c77205f893174948b7bd175646f59a00

Patients with Head-and-Neck Cancer

Autor: Bernd Kremer, Bjorn Winkens, Sorina R. Simon, Walmari Pilz, Laura W. J. Baijens, Iris Krebbers

Publikováno v: Folia Phoniatrica et Logopaedica, 73(4), 308-315. S. Karger AG

Objective: Affective symptoms are common in patients with head-and-neck cancer. This study determined the association between the presence of aspiration and symptoms of anxiety and depression, as well as patient characteristics in patients with head-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5a57db19ac9310e9b24cdf07814a62
https://doi.org/10.1159/000508367

Evaluation Criteria for Chromosome Instability Detection by FISH to Predict Malignant Progression in Premalignant Glottic Laryngeal Lesions

Autor: Verona E. Bergshoeff, Maschenka C. A. Balkenhol, Annick Haesevoets, Andrea Ruland, Michelene N. Chenault, Rik C. Nelissen, Carine J. Peutz, Ruud Clarijs, Jeroen A. W. M. Van der Laak, Robert P. Takes, Michiel W. Van den Brekel, Marie-Louise F. Van Velthuysen, Frans C. S. Ramaekers, Bernd Kremer, Ernst-Jan M. Speel

Publikováno v: Cancers, 14(13):3260. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, 14
Cancers; Volume 14; Issue 13; Pages: 3260
Cancers, 14, 13

BACKGROUND: The definition of objective, clinically applicable evaluation criteria for FISH 1c/7c in laryngeal precursor lesions for the detection of chromosome instability (CI). Copy Number Variations (CNV) for chromosomes 1 and 7 reflect the genera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c420d33fa270c4d6ed0f527f830449ca
https://cris.maastrichtuniversity.nl/en/publications/4b7ea431-de81-4f69-b196-11e252187297