Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Bernd, Kammerer"'
Autor:
Johannes Zeller, Karen S Cheung Tung Shing, Tracy L Nero, James D McFadyen, Guy Krippner, Balázs Bogner, Sheena Kreuzaler, Jurij Kiefer, Verena K Horner, David Braig, Habiba Danish, Sara Baratchi, Mark Fricke, Xiaowei Wang, Michel G Kather, Bernd Kammerer, Kevin J Woollard, Prerna Sharma, Craig J Morton, Geoffrey Pietersz, Michael W Parker, Karlheinz Peter, Steffen U Eisenhardt
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 1, Pp n/a-n/a (2023)
Abstract C‐reactive protein (CRP) is an early‐stage acute phase protein and highly upregulated in response to inflammatory reactions. We recently identified a novel mechanism that leads to a conformational change from the native, functionally rel
Externí odkaz:
https://doaj.org/article/8b881686a26748449e95ec090389d914
Autor:
Moritz Benka, Kristof Görlitz, Michael C. Schöttgen, Simon Lagies, Daniel A. Mohl, Michel Kather, Iwanette Du Preez-Bruwer, Davis Mumbengegwi, Robin Teufel, Stefanie Kowarschik, Roman Huber, Dietmar A. Plattner, Bernd Kammerer
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1168 (2023)
The vast pool of structurally and functionally distinct secondary metabolites (i.e., natural products (NPs)) is constantly being expanded, a process also driven by the rapid progress in the development of analytical techniques. Such NPs often show po
Externí odkaz:
https://doaj.org/article/12bf121d104747f592dc6ff8907287dc
Autor:
Britta Frensch, Thorsten Lechtenberg, Michel Kather, Zeynep Yunt, Martin Betschart, Bernd Kammerer, Steffen Lüdeke, Michael Müller, Jörn Piel, Robin Teufel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Rubromycin family of natural products belongs to aromatic polyketides with diverse bioactivities, but details of their biosynthesis are limited. Here, the authors report the complete in vitro reconstitution of enzymatic formation of the spiroketal mo
Externí odkaz:
https://doaj.org/article/2c66fdf660624127ac29372efbed73b9
Autor:
Daniel A. Mohl, Simon Lagies, Kyra Zodel, Matthias Zumkeller, Asin Peighambari, Athina Ganner, Dietmar A. Plattner, Elke Neumann-Haefelin, Mojca Adlesic, Ian J. Frew, Bernd Kammerer
Publikováno v:
Cells, Vol 12, Iss 8, p 1102 (2023)
Clear cell renal cell carcinoma (ccRCC) accounts for ~75% of kidney cancers. The biallelic inactivation of the von Hippel–Lindau tumor suppressor gene (VHL) is the truncal driver mutation of most cases of ccRCC. Cancer cells are metabolically repro
Externí odkaz:
https://doaj.org/article/c14feeae9dc44cb78d95daac398001d5
Autor:
Athina Ganner, Antonia Philipp, Simon Lagies, Laura Wingendorf, Lu Wang, Felicitas Pilz, Thomas Welte, Kelli Grand, Soeren S. Lienkamp, Marinella Klein, Bernd Kammerer, Ian J. Frew, Gerd Walz, Elke Neumann-Haefelin
Publikováno v:
Cells, Vol 12, Iss 6, p 835 (2023)
Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype of renal cancer, and inactivation of the VHL tumor suppressor gene is found in almost all cases of hereditary and sporadic ccRCCs. CcRCC is associated with the reprogramm
Externí odkaz:
https://doaj.org/article/b0fde4aca05f4c8a94fede21fde25ff8
Autor:
Danye Qiu, Miranda S. Wilson, Verena B. Eisenbeis, Robert K. Harmel, Esther Riemer, Thomas M. Haas, Christopher Wittwer, Nikolaus Jork, Chunfang Gu, Stephen B. Shears, Gabriel Schaaf, Bernd Kammerer, Dorothea Fiedler, Adolfo Saiardi, Henning J. Jessen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Myo-Inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) are important second messengers but their analysis remains challenging. Here, the authors develop a capillary electrophoresis-mass spectrometry method for the identification and quantitati
Externí odkaz:
https://doaj.org/article/a6c9f68025794db3aaf128b31c15130b
Autor:
Stephanie Ketterer, Julia Mitschke, Anett Ketscher, Manuel Schlimpert, Wilfried Reichardt, Natascha Baeuerle, Maria Elena Hess, Patrick Metzger, Melanie Boerries, Christoph Peters, Bernd Kammerer, Tilman Brummer, Florian Steinberg, Thomas Reinheckel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
The lysosomal aspartic protease Cathepsin D (CTSD) is associated with breast cancer progression. Here the authors show that selective inactivation of CTSD in mammary epithelium delays tumor onset due to impaired mTORC1 signaling, but resumes malignan
Externí odkaz:
https://doaj.org/article/081372ca21394e578d2d46c800e56a5a
Autor:
Simon Lagies, Daqiang Pan, Daniel A. Mohl, Dietmar A. Plattner, Ian E. Gentle, Bernd Kammerer
Publikováno v:
Cells, Vol 12, Iss 5, p 692 (2023)
Metabolomics has expanded from cellular to subcellular level to elucidate subcellular compartmentalization. By applying isolated mitochondria to metabolome analysis, the hallmark of mitochondrial metabolites has been unraveled, showing compartment-sp
Externí odkaz:
https://doaj.org/article/261552876e524516a6e77063649c5715
Autor:
Arne Liebau, Sören Schilp, Kenneth Mugridge, Ilona Schön, Michel Kather, Bernd Kammerer, Jochen Tillein, Susanne Braun, Stefan K. Plontke
Publikováno v:
Frontiers in Neurology, Vol 10 (2020)
Glucocorticoids are used intra-operatively in cochlear implant surgeries to reduce the inflammatory reaction caused by insertion trauma and the foreign body response against the electrode carrier after cochlear implantation. To prevent higher systemi
Externí odkaz:
https://doaj.org/article/768dea4355c646f4a308965772625d39
Autor:
Paul T. Brinkkoetter, Tillmann Bork, Sarah Salou, Wei Liang, Athanasia Mizi, Cem Özel, Sybille Koehler, H. Henning Hagmann, Christina Ising, Alexander Kuczkowski, Svenia Schnyder, Ahmed Abed, Bernhard Schermer, Thomas Benzing, Oliver Kretz, Victor G. Puelles, Simon Lagies, Manuel Schlimpert, Bernd Kammerer, Christoph Handschin, Christoph Schell, Tobias B. Huber
Publikováno v:
Cell Reports, Vol 27, Iss 5, Pp 1551-1566.e5 (2019)
Summary: The cellular responses induced by mitochondrial dysfunction remain elusive. Intrigued by the lack of almost any glomerular phenotype in patients with profound renal ischemia, we comprehensively investigated the primary sources of energy of g
Externí odkaz:
https://doaj.org/article/797ae05543d74f758e692293a53995ac