Zobrazeno 1 - 10
of 383
pro vyhledávání: '"Bernd, Kaina"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Despite the frequent use of ionising radiation (IR) in therapy and diagnostics and the unavoidable exposure to external radiation sources, our knowledge regarding the radiosensitivity of human blood cell populations is limited and published
Externí odkaz:
https://doaj.org/article/5f553cd3447e4cbc8dd6189dbab2760a
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Radiation concomitant with the DNA methylating drug temozolomide (TMZ) is the gold standard in the treatment of glioblastoma. In this adjuvant setting, TMZ is regarded to be a radiation sensitizer. However, similar to ionising radiation, TMZ induces
Externí odkaz:
https://doaj.org/article/6454b842cbcf4bd7b2041f23a42446e6
Publikováno v:
Cells, Vol 11, Iss 16, p 2588 (2022)
A first-line therapeutic for high-grade glioma, notably glioblastoma (GBM), is the DNA methylating drug temozolomide (TMZ). Previously, we showed that TMZ induces not only apoptosis and autophagy, but also cellular senescence (CSEN). We presented the
Externí odkaz:
https://doaj.org/article/ef861e9c40874456ada9ff886a1edc06
Autor:
Senthiladipan Venkatachalam, Esther Mettler, Christian Fottner, Matthias Miederer, Bernd Kaina, Matthias M. Weber
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 7, Iss , Pp 1-8 (2017)
Background: Overexpression of the insulin-like growth factor-1 receptor (IGF-1R) is associated with increased cell proliferation, differentiation, transformation, and tumorigenicity. Additionally, signaling involved in the resistance of cancer cells
Externí odkaz:
https://doaj.org/article/5dc4507288584c5586c23a69acb9af70
Autor:
Teodora Nikolova, Bernd Kaina, Kerstin Borgmann, Mengwan Wang, Nadine Piecha, Andrea Piée-Staffa, Nancy Berte
Structures of CCNU and HR inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd7ea25c69df8cabfa5b66788ba6249
https://doi.org/10.1158/1535-7163.22506594
https://doi.org/10.1158/1535-7163.22506594
PDF file - 78 KB, Apoptosis and necrosis rates of cell death data for glioblastoma and malignant melanoma cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cfe7913f1c6675a7a1406700ce0c356
https://doi.org/10.1158/1535-7163.22499812
https://doi.org/10.1158/1535-7163.22499812
Autor:
Teodora Nikolova, Bernd Kaina, Kerstin Borgmann, Mengwan Wang, Nadine Piecha, Andrea Piée-Staffa, Nancy Berte
Malignant gliomas exhibit a high level of intrinsic and acquired drug resistance and have a dismal prognosis. First- and second-line therapeutics for glioblastomas are alkylating agents, including the chloroethylating nitrosoureas (CNU) lomustine, ni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fce105862f01cb99f2b33a6059b2ad7
https://doi.org/10.1158/1535-7163.c.6538440.v1
https://doi.org/10.1158/1535-7163.c.6538440.v1
PDF file - 53 KB, Doubling times for selected cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798c20d3728e6fc491a27e04abd3cca7
https://doi.org/10.1158/1535-7163.22499818.v1
https://doi.org/10.1158/1535-7163.22499818.v1
The major cytotoxic DNA adduct induced by temozolomide and other methylating agents used in malignant glioma and metastasized melanoma therapy is O6-methylguanine (O6-MeG). This primary DNA damage is converted by mismatch repair into secondary lesion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c48dc11dfe708612e31a50f496cacc38
https://doi.org/10.1158/1535-7163.c.6536269
https://doi.org/10.1158/1535-7163.c.6536269
PDF file - 78 KB, Apoptosis and necrosis rates of cell death data for fibroblasts and lymphoblastoid cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2e4929ae5bc398e7055530af034060
https://doi.org/10.1158/1535-7163.22499815
https://doi.org/10.1158/1535-7163.22499815