Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Bernd, Gerhartz"'
Autor:
Nello Mainolfi, Takeru Ehara, Rajeshri G. Karki, Karen Anderson, Aengus Mac Sweeney, Sha-Mei Liao, Upendra A. Argikar, Keith Jendza, Chun Zhang, James Powers, Daniel W. Klosowski, Maura Crowley, Toshio Kawanami, Jian Ding, Myriam April, Cornelia Forster, Michael Serrano-Wu, Michael Capparelli, Rrezarta Ramqaj, Catherine Solovay, Frederic Cumin, Thomas M. Smith, Luciana Ferrara, Wendy Lee, Debby Long, Melissa Prentiss, Andrea De Erkenez, Louis Yang, Fang Liu, Holger Sellner, Finton Sirockin, Eric Valeur, Paulus Erbel, Daniela Ostermeier, Paul Ramage, Bernd Gerhartz, Anna Schubart, Stefanie Flohr, Nathalie Gradoux, Roland Feifel, Barbara Vogg, Christian Wiesmann, Jürgen Maibaum, Jörg Eder, Richard Sedrani, Richard A. Harrison, Muneto Mogi, Bruce D. Jaffee, Christopher M. Adams
Publikováno v:
Journal of Medicinal Chemistry. 63:5697-5722
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::161530bd60ced781537b4b5cf97869fc
https://doi.org/10.1021/acs.jmedchem.9b01870
https://doi.org/10.1021/acs.jmedchem.9b01870
Autor:
Edwin Liu, Kristen McDaniel, Stephanie Case, Liping Yu, Bernd Gerhartz, Nils Ostermann, Gabriela Fankhauser, Valerie Hungerford, Chao Zou, Marcel Luyten, Katherine J. Seidl, Aaron W. Michels
Publikováno v:
Autoimmune Diseases, Vol 2014 (2014)
Class II major histocompatibility molecules confer disease risk in Celiac disease (CD) by presenting gliadin peptides to CD4 T cells in the small intestine. Deamidation of gliadin peptides by tissue transglutaminase creates immunogenic peptides prese
Externí odkaz:
https://doaj.org/article/3ed6788713dc4635b3bc81285e3b9baa
Autor:
Paul Erbel, Bernd Gerhartz, Frederic Cumin, Jürgen Maibaum, Nils Ostermann, Edwige Lorthiois, Claudio Dalvit, Thomas Zoller, Stefan Andreas Randl, Simon Rüdisser, Ulrich Hommel, Anna Vulpetti, Aengus Mac Sweeney, Bahaa Salem
Publikováno v:
Journal of Medicinal Chemistry. 60:1946-1958
Chronic dysregulation of alternative complement pathway activation has been associated with diverse clinical disorders including age-related macular degeneration and paroxysmal nocturnal hemoglobinurea. Factor D is a trypsin-like serine protease with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfc49de28df6dccc09e8711c747aed7
https://doi.org/10.1021/acs.jmedchem.6b01684
https://doi.org/10.1021/acs.jmedchem.6b01684
Autor:
Claus Ehrhardt, Takatoshi Kosaka, Jörg Trappe, Richard Sedrani, Bernd Gerhartz, Jürgen Maibaum, Simon Ruedisser, Sabine Geisse, Dean F. Rigel, Frederic Cumin, Johannes Ottl, Nils Ostermann, Trixie Wagner, Markus Krömer, Andreas Marzinzik, Eric Vangrevelinghe, Paul Richert, Edgar Jacoby, Martin Klumpp, Daniel K. Baeschlin, Eric Francotte, Randy L. Webb, J. Constanze D. Hartwieg, Werner Breitenstein, Ulrich Hassiepen
Publikováno v:
Journal of Medicinal Chemistry. 56:2196-2206
A small library of fragments comprising putative recognition motifs for the catalytic dyad of aspartic proteases was generated by in silico similarity searches within the corporate compound deck based on rh-renin active site docking and scoring filte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56536415f82cd33ef62b0ef099e5195e
https://doi.org/10.1021/jm301706j
https://doi.org/10.1021/jm301706j
Autor:
Frederic Cumin, Bernd Kinzel, Anna Vulpetti, Antonio M. Risitano, Richard A. Harrison, Kamal Fettis, Aengus Mac Sweeney, Stefan Andreas Randl, Edwige Lorthiois, Fabrice A. Kolb, Nils Ostermann, Solene Dussauge, Corinne Durand, Nicola Hughes, Bernd Gerhartz, Karen Anderson, Samuel Barbieri, Paul Erbel, Omar Delgado, Jörg Eder, Ulrich Hommel, Stefanie Flohr, Simon Rüdisser, Anna Schubart, Ty Gould, Bruce D Jaffee, Jürgen Maibaum, Julia Wagner, Sha-Mei Liao
Publikováno v:
Nature chemical biology. 12(12)
Complement is a key component of the innate immune system, recognizing pathogens and promoting their elimination. Complement component 3 (C3) is the central component of the system. Activation of C3 can be initiated by three distinct routes-the class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2c3a47759beca17b7b3f2b775e9551
https://pubmed.ncbi.nlm.nih.gov/27857140
https://pubmed.ncbi.nlm.nih.gov/27857140
Autor:
A. Hein, P. Erbel, S. Gil-Parrado, A. Bernardi, Ursula Bodendorf, D. Vinzenz, Bernd Gerhartz, C. Logel, A. Mac Sweeney
Publikováno v:
Journal of Molecular Biology. 384:228-239
Procollagen C-peptidase, also known as bone morphogenetic protein 1 (BMP-1), is a multidomain, zinc endopeptidase of the astacin M12A family. BMP-1 is the prototype of a small group of proteases that have key roles in extracellular matrix formation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2816eaa06fe761b7b4f394fe149fad62
https://doi.org/10.1016/j.jmb.2008.09.029
https://doi.org/10.1016/j.jmb.2008.09.029
Autor:
Marion Mahnke, Benoit Pierrat, Robert Mader, Tewis Bouwmeester, Bernd Gerhartz, Susanne Worpenberg, Jean-Marc Schlaeppi, Gerard Joberty, Amaury Ernesto Fernandez-Montalvan
Publikováno v:
FEBS Journal. 274:4256-4270
Ubiquitin specific protease 7 (USP7) belongs to the family of deubiquitinating enzymes. Among other functions, USP7 is involved in the regulation of stress response pathways, epigenetic silencing and the progress of infections by DNA viruses. USP7 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d902de2aaf3a82202daebca27153be6a
https://doi.org/10.1111/j.1742-4658.2007.05952.x
https://doi.org/10.1111/j.1742-4658.2007.05952.x
Autor:
Silvio Roggo, Cecile Delmas, Nathalie Bürstner, Matthias Rottmann, Jason Murphy, Manuel Mihalic, Jutta Blank, Dominik Pistorius, Nils Ostermann, Dominic Hoepfner, Alexandra Hinniger, Brigitta Liechty, Esther K. Schmitt, Markus Schirle, Jason R. Thomas, Felix Freuler, Bernd Gerhartz
Publikováno v:
Chembiochem : a European journal of chemical biology. 16(17)
Malaria continues to be one of the most devastating human diseases despite many efforts to limit its spread by prevention of infection or by pharmaceutical treatment of patients. We have conducted a screen for antiplasmodial compounds by using a natu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe4dc9bff950984b0487cba0a3fa51d
https://pubmed.ncbi.nlm.nih.gov/26472355
https://pubmed.ncbi.nlm.nih.gov/26472355
Autor:
Ireos Filipuzzi, Johann Zimmermann, Johannes Ottl, Lukas Leder, Alain Schilb, Beate Leuenberger, Felix Freuler, Bernd Gerhartz, Virginie Riou, Aline Tirat, Ulf Eidhoff, Lorenz M. Mayr, Susanne Worpenberg, Thomas Stettler
Publikováno v:
Analytical Biochemistry. 343:244-255
Deubiquitinating enzymes (DUBs) catalyze the removal of attached ubiquitin molecules from amino groups of target proteins. The large family of DUBs plays an important role in the regulation of the intracellular homeostasis of different proteins and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a54e322618b6458d7fd23c329ea0b7
https://doi.org/10.1016/j.ab.2005.04.023
https://doi.org/10.1016/j.ab.2005.04.023
Autor:
David Ruiz-Carrillo, Hans-Ulrich Demuth, Steffen Roßner, Ulrike Zeitschel, Thomas Rudolph, Ingo Schulz, Volker Bigl, Bernd Gerhartz, Jens-Ulrich Rahfeld
Publikováno v:
Journal of Neurochemistry. 94:970-979
For a long time, prolyl endopeptidase (PEP) was believed to inactivate neuropeptides in the extracellular space. However, reports on the intracellular activity of PEP suggest additional, as yet unidentified, physiological functions for this enzyme. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58c0e4ed1e90fd0308feda0a905b5eae
https://doi.org/10.1111/j.1471-4159.2005.03237.x
https://doi.org/10.1111/j.1471-4159.2005.03237.x