Zobrazeno 1 - 10 of 180 pro vyhledávání: '"Bernd, Clement"'
1
Akademický článek
Reduction of Hydrogen Peroxide by Human Mitochondrial Amidoxime Reducing Component Enzymes
Autor: Sophia Rixen, Patrick M. Indorf, Christian Kubitza, Michel A. Struwe, Cathrin Klopp, Axel J. Scheidig, Thomas Kunze, Bernd Clement
Publikováno v: Molecules, Vol 28, Iss 17, p 6384 (2023)
The mitochondrial amidoxime reducing component (mARC) is a human molybdoenzyme known to catalyze the reduction of various N-oxygenated substrates. The physiological function of mARC enzymes, however, remains unknown. In this study, we examine the red
Externí odkaz: https://doaj.org/article/96401eb5c24d4951a7e7703198414bbe
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2
Akademický článek
The History of mARC
Autor: Bernd Clement, Michel A. Struwe
Publikováno v: Molecules, Vol 28, Iss 12, p 4713 (2023)
The mitochondrial amidoxime-reducing component (mARC) is the most recently discovered molybdoenzyme in humans after sulfite oxidase, xanthine oxidase and aldehyde oxidase. Here, the timeline of mARC’s discovery is briefly described. The story begin
Externí odkaz: https://doaj.org/article/e6a1536a62424605b9902f53cc6e37e7
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4
Akademický článek
Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer
Autor: Inken Flörkemeier, Tamara N. Steinhauer, Nina Hedemann, Magnus Ölander, Per Artursson, Bernd Clement, Dirk O. Bauerschlag
Publikováno v: Therapeutic Advances in Medical Oncology, Vol 13 (2021)
Background: Ovarian cancer (OvCa) constitutes a rare and highly aggressive malignancy and is one of the most lethal of all gynaecologic neoplasms. Due to chemotherapy resistance and treatment limitations because of side effects, OvCa is still not suf
Externí odkaz: https://doaj.org/article/8b89334405764c299bc1e0e335c0f7dc
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6
Data from The Novel Dual Topoisomerase Inhibitor P8-D6 Shows Anti-myeloma Activity In Vitro and In Vivo
Autor: Matthias Peipp, Martin Gramatzki, Bernd Clement, Dirk O. Bauerschlag, Andreas Günther, Inken Floerkemeier, Hauke Wilcken, Steffen Krohn, Carina Lynn Gehlert, Christian Kellner, Katja Klausz
P8-D6 is a novel dual inhibitor of human topoisomerase I (TOP1) and II (TOP2) with broad pro-apoptotic antitumor activity. NCI-60 screening revealed markedly improved cytotoxicity of P8-D6 against solid and leukemia cell lines compared with other sin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da6d0e8e73b4e09348a7b5d8e131497
https://doi.org/10.1158/1535-7163.c.6543349.v1
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9
The Novel Dual Topoisomerase Inhibitor P8-D6 Shows Anti-myeloma Activity In Vitro and In Vivo
Autor: Hauke Wilcken, Dirk Bauerschlag, Bernd Clement, Inken Floerkemeier, Katja Klausz, Martin Gramatzki, Steffen Krohn, Christian Kellner, Matthias Peipp, Andreas Guenther, Carina Lynn Gehlert
Publikováno v: Molecular Cancer Therapeutics. 21:70-78
P8-D6 is a novel dual inhibitor of human topoisomerase I (TOP1) and II (TOP2) with broad pro-apoptotic antitumor activity. NCI-60 screening revealed markedly improved cytotoxicity of P8-D6 against solid and leukemia cell lines compared with other sin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5140012fe3e49dcf1bf959c2d91c36f
https://doi.org/10.1158/1535-7163.mct-21-0119
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10
Akademický článek
The Aza-Analogous Benzo[c]phenanthridine P8-D6 Acts as a Dual Topoisomerase I and II Poison, thus Exhibiting Potent Genotoxic Properties
Autor: Georg Aichinger, Falk-Bach Lichtenberger, Tamara N. Steinhauer, Inken Flörkemeier, Giorgia Del Favero, Bernd Clement, Doris Marko
Publikováno v: Molecules, Vol 25, Iss 7, p 1524 (2020)
The benzo[c]phenanthridine P8-D6 was recently found to suppress the catalytic activity of both human topoisomerase (Topo) I and II. Concomitantly, potent cytotoxic activity was observed in different human tumor cell lines, raising questions about the
Externí odkaz: https://doaj.org/article/1d43c6f252b94497974bda9b2f236fd9
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