Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Bernardo Yusta"'
Autor:
Brandon L. Panaro, Bernardo Yusta, Dianne Matthews, Jacqueline A. Koehler, Youngmi Song, Darleen A. Sandoval, Daniel J. Drucker
Publikováno v:
Molecular Metabolism, Vol 37, Iss , Pp 100990- (2020)
Objective: Glucagon-like peptide-1 is a nutrient-sensitive hormone secreted from enteroendocrine L cells within the small and large bowel. Although GLP-1 levels rise rapidly in response to food ingestion, the greatest density of L cells is localized
Externí odkaz:
https://doaj.org/article/1094acce8f4b47ebb87235202b9bfaef
Autor:
Anita Patel, Bernardo Yusta, Dianne Matthews, Maureen J. Charron, Randy J. Seeley, Daniel J. Drucker
Publikováno v:
Molecular Metabolism, Vol 16, Iss , Pp 45-54 (2018)
Objective: Therapeutic interventions that improve glucose homeostasis such as attenuation of glucagon receptor (Gcgr) signaling and bariatric surgery share common metabolic features conserved in mice and humans. These include increased circulating le
Externí odkaz:
https://doaj.org/article/b4ffd5cf5a9448ba814c9fc938ce9d5c
Autor:
Bernardo Yusta, Dianne Matthews, Grace B. Flock, John R. Ussher, Brigitte Lavoie, Gary M. Mawe, Daniel J. Drucker
Publikováno v:
Molecular Metabolism, Vol 6, Iss 6, Pp 503-511 (2017)
Objective: Glucagon-like peptides (GLPs) are secreted from enteroendocrine cells in response to nutrients and bile acids and control metabolism via actions on structurally-related yet distinct G protein coupled receptors. GLP-1 regulates gut motility
Externí odkaz:
https://doaj.org/article/17791cc01a3543ecbd4dd42c3738671f
Autor:
Jennifer Lee, Jacqueline Koehler, Bernardo Yusta, Jasmine Bahrami, Dianne Matthews, Mahroukh Rafii, Paul B. Pencharz, Daniel J. Drucker
Publikováno v:
Molecular Metabolism, Vol 6, Iss 3, Pp 245-255 (2017)
Objective: Glucagon-like peptide-2 (GLP-2) is co-secreted with GLP-1 from gut endocrine cells, and both peptides act as growth factors to expand the surface area of the mucosal epithelium. Notably, GLP-2 also enhances glucose and lipid transport in e
Externí odkaz:
https://doaj.org/article/ea513822439743ba84a3403b1a78d882
Glucagon-like peptide-2 (GLP-2) secreted from enteroendocrine cells exerts proabsorptive, regenerative, and cytoprotective actions in the normal and injured gut epithelium. Hence, sustained GLP-2 receptor (GLP-2R) activation represents a strategy und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7aa05fae35605be20c06917d2783dd0
https://doi.org/10.1158/0008-5472.c.6497435
https://doi.org/10.1158/0008-5472.c.6497435
Supplementary Table 1, Figures 1-6 from Glucagon-like Peptide-2 Does Not Modify the Growth or Survival of Murine or Human Intestinal Tumor Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444fd51897ac8c9a6518a8da440c3303
https://doi.org/10.1158/0008-5472.22374413.v1
https://doi.org/10.1158/0008-5472.22374413.v1
Autor:
Chi Kin, Wong, Bernardo, Yusta, Jacqueline A, Koehler, Laurie L, Baggio, Brent A, McLean, Dianne, Matthews, Randy J, Seeley, Daniel J, Drucker
Publikováno v:
Cell Metabolism. 34:1514-1531.e7
Gut intraepithelial lymphocytes (IELs) are thought to calibrate glucagon-like peptide 1 (GLP-1) bioavailability, thereby regulating systemic glucose and lipid metabolism. Here, we show that the gut IEL GLP-1 receptor (GLP-1R) is not required for ente
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be265abee8a216a6dc4527c836883210
https://doi.org/10.1016/j.cmet.2022.08.003
https://doi.org/10.1016/j.cmet.2022.08.003
Autor:
Laurie L. Baggio, Dianne Matthews, Elodie M. Varin, Shai Z Fuchs, Daniel J. Drucker, Bernardo Yusta
Publikováno v:
Journal of the Endocrine Society
A GLP-2 analogue is used in individuals with intestinal failure at risk for liver disease, yet the hepatic actions of GLP-2 are not understood. Treatment of high fat diet (HFD)-fed mice with GLP-2 did not modify the development of hepatosteatosis or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68f89bc2aa6280fb2b9e5e5c59dd5a8
https://doi.org/10.1210/jendso/bvaa046.2181
https://doi.org/10.1210/jendso/bvaa046.2181
Autor:
Laurie L. Baggio, Shai Fuchs, Dianne Matthews, Daniel J. Drucker, Elodie M. Varin, Bernardo Yusta
Publikováno v:
JCI Insight
A glucagon-like peptide-2 (GLP-2) analog is used in individuals with intestinal failure who are at risk for liver disease, yet the hepatic actions of GLP-2 are not understood. Treatment of high-fat diet–fed (HFD-fed) mice with GLP-2 did not modify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5fe6a3cd5a0ff20cf471c74dcace06f
https://pubmed.ncbi.nlm.nih.gov/32191643
https://pubmed.ncbi.nlm.nih.gov/32191643
Autor:
Daniel J. Drucker, Dianne Matthews, Anita Patel, Randy J. Seeley, Maureen J. Charron, Bernardo Yusta
Publikováno v:
Molecular Metabolism, Vol 16, Iss, Pp 45-54 (2018)
Objective: Therapeutic interventions that improve glucose homeostasis such as attenuation of glucagon receptor (Gcgr) signaling and bariatric surgery share common metabolic features conserved in mice and humans. These include increased circulating le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64daa463775693215d39b29db92fe80d
https://doi.org/10.1016/j.molmet.2018.06.006
https://doi.org/10.1016/j.molmet.2018.06.006