Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Bernardo Stutz"'
Autor:
Di Xie, Bernardo Stutz, Feng Li, Fan Chen, Haining Lv, Matija Sestan-Pesa, Jonatas Catarino, Jianlei Gu, Hongyu Zhao, Christopher E. Stoddard, Gordon G. Carmichael, Marya Shanabrough, Hugh S. Taylor, Zhong-Wu Liu, Xiao-Bing Gao, Tamas L. Horvath, Yingqun Huang
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 19 (2022)
The TET family of dioxygenases promote DNA demethylation by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC). Hypothalamic agouti-related peptide–expressing (AGRP-expressing) neurons play an essential role in driving feeding, while also
Externí odkaz:
https://doaj.org/article/6327ef9376aa4b878e87ef53442e9d52
Autor:
Bernardo Stutz, Carole Nasrallah, Mariana Nigro, Daniel Curry, Zhong-Wu Liu, Xiao-Bing Gao, John D. Elsworth, Liat Mintz, Tamas L. Horvath
Publikováno v:
Molecular Metabolism, Vol 24, Iss , Pp 120-138 (2019)
Objective: Dopamine neurons in the Substantia nigra (SN) play crucial roles in control of voluntary movement. Extensive degeneration of this neuronal population is the cause of Parkinson's disease (PD). Many factors have been linked to SN DA neuronal
Externí odkaz:
https://doaj.org/article/45a9a1775cc548c283b17e25f01ef5ae
Autor:
Jae-Eun Song, Tiago C. Alves, Bernardo Stutz, Matija Šestan-Peša, Nicole Kilian, Sungho Jin, Sabrina Diano, Richard G. Kibbey, Tamas L. Horvath
Publikováno v:
Metabolites, Vol 11, Iss 5, p 322 (2021)
In the presence of high abundance of exogenous fatty acids, cells either store fatty acids in lipid droplets or oxidize them in mitochondria. In this study, we aimed to explore a novel and direct role of mitochondrial fission in lipid homeostasis in
Externí odkaz:
https://doaj.org/article/79220711625c484daab929828974ea71
Autor:
Bernardo Stutz, Tamas L Horvath
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 1, Pp 3-5 (2015)
Abstract Psychiatric disorders, which include a variety of distinct infirmities, affect millions of people worldwide. Without intervention, the impact of these conditions is devastating, compromising the daily life of patients and their relatives. Al
Externí odkaz:
https://doaj.org/article/81731265e0634eacaccfd70d3d242a8d
Autor:
Bernardo Stutz, Michael J. Waterson, Matija Šestan-Peša, Marcelo O. Dietrich, Mario Škarica, Nenad Sestan, Bence Racz, Aletta Magyar, Peter Sotonyi, Zhong-Wu Liu, Xiao-Bing Gao, Ferenc Matyas, Milan Stoiljkovic, Tamas L. Horvath
Publikováno v:
Mol Psychiatry
Hypothalamic agouti-related peptide and neuropeptide Y-expressing (AgRP) neurons have a critical role in both feeding and non-feeding behaviors of newborn, adolescent, and adult mice, suggesting their broad modulatory impact on brain functions. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89ac0d55bdd8d4159d826101d94d997
https://doi.org/10.1038/s41380-022-01691-8
https://doi.org/10.1038/s41380-022-01691-8
Autor:
Heiko Endle, Guilherme Horta, Bernardo Stutz, Muthuraman Muthuraman, Irmgard Tegeder, Yannick Schreiber, Isabel Faria Snodgrass, Robert Gurke, Zhong-Wu Liu, Matija Sestan-Pesa, Konstantin Radyushkin, Nora Streu, Wei Fan, Jan Baumgart, Yan Li, Florian Kloss, Sergiu Groppa, Nils Opel, Udo Dannlowski, Hans J. Grabe, Frauke Zipp, Bence Rácz, Tamas L. Horvath, Robert Nitsch, Johannes Vogt
Publikováno v:
Nat Metab
Phospholipid levels are influenced by peripheral metabolism. Within the central nervous system, synaptic phospholipids regulate glutamatergic transmission and cortical excitability. Whether changes in peripheral metabolism affect brain lipid levels a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea1034fa0ea8cde9041234d732bd739
https://doi.org/10.1038/s42255-022-00589-7
https://doi.org/10.1038/s42255-022-00589-7
Publikováno v:
Science Advances. 8
The ventromedial hypothalamus (VMH) is known to regulate body weight and counterregulatory response. However, how VMH neurons regulate lipid metabolism and energy balance remains unknown. O-linked β- d - N -acetylglucosamine (O-GlcNAc) modification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea878d15d3138306e6716a50defcc92
https://doi.org/10.1126/sciadv.abn8092
https://doi.org/10.1126/sciadv.abn8092
Hunger-promoting AgRP neurons trigger an astrocyte-mediated feed-forward autoactivation loop in mice
Autor:
Bernardo Stutz, Jae Eun Song, Jae Geun Kim, Tamas L. Horvath, Xiao-Bing Gao, Zhong-Wu Liu, Luis Varela
Publikováno v:
J Clin Invest
Hypothalamic feeding circuits have been identified as having innate synaptic plasticity, mediating adaption to the changing metabolic milieu by controlling responses to feeding and obesity. However, less is known about the regulatory principles under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36f9e7e8accb50b56e6e250b7782ac1
https://europepmc.org/articles/PMC8121506/
https://europepmc.org/articles/PMC8121506/
Autor:
Nicole Kilian, Tiago C. Alves, Bernardo Stutz, Matija Sestan-Pesa, Sabrina Diano, Sungho Jin, Tamas L. Horvath, Jae Eun Song, Richard G. Kibbey
Publikováno v:
Metabolites
Volume 11
Issue 5
Metabolites, Vol 11, Iss 322, p 322 (2021)
Volume 11
Issue 5
Metabolites, Vol 11, Iss 322, p 322 (2021)
In the presence of high abundance of exogenous fatty acids, cells either store fatty acids in lipid droplets or oxidize them in mitochondria. In this study, we aimed to explore a novel and direct role of mitochondrial fission in lipid homeostasis in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca2672f8c4b71ac8c8e9d137e414dff
https://pubmed.ncbi.nlm.nih.gov/34069800
https://pubmed.ncbi.nlm.nih.gov/34069800
Autor:
Tiago C. Alves, Matija Sestan-Pesa, Jae Eun Song, Richard G. Kibbey, Bernardo Stutz, Nicole Kilian, Sabrina Diano, Tamas L. Horvath
The bioenergetic function of mitochondrial fission is associated with uncoupled respiration or elimination of damaged mitochondria to maintain a healthy mitochondrial population. In the presence of a high abundance of exogenous fatty acids, cells can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5c23e9e81f7b3e56988c49fb88899c4
https://doi.org/10.1101/2020.10.17.343616
https://doi.org/10.1101/2020.10.17.343616