Infection Biomarkers Based on Metabolomics

Autor: Rúben Araújo, Luís F. N. Bento, Tiago A. H. Fonseca, Cristiana P. Von Rekowski, Bernardo Ribeiro da Cunha, Cecília R. C. Calado

Publikováno v: Metabolites, Vol 12, Iss 2, p 92 (2022)

Current infection biomarkers are highly limited since they have low capability to predict infection in the presence of confounding processes such as in non-infectious inflammatory processes, low capability to predict disease outcomes and have limited

Externí odkaz: https://doaj.org/article/917498403a8c4d7285575443634d77d6

Metabolic Fingerprinting with Fourier-Transform Infrared (FTIR) Spectroscopy: Towards a High-Throughput Screening Assay for Antibiotic Discovery and Mechanism-of-Action Elucidation

Autor: Bernardo Ribeiro da Cunha, Luís P. Fonseca, Cecília R.C. Calado

Publikováno v: Metabolites, Vol 10, Iss 4, p 145 (2020)

The discovery of antibiotics has been slowing to a halt. Phenotypic screening is once again at the forefront of antibiotic discovery, yet Mechanism-Of-Action (MOA) identification is still a major bottleneck. As such, methods capable of MOA elucidatio

Externí odkaz: https://doaj.org/article/200b833736d64c6f92705fac3724bf9f

Simultaneous elucidation of antibiotic mechanism of action and potency with high-throughput Fourier-transform infrared (FTIR) spectroscopy and machine learning

Autor: Cecília R.C. Calado, Luís P. Fonseca, Bernardo Ribeiro da Cunha

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

The low rate of discovery and rapid spread of resistant pathogens have made antibiotic discovery a worldwide priority. In cell-based screening, the mechanism of action (MOA) is identified after antimicrobial activity. This increases rediscovery, impa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05be7977ab8a6a08a039a9ac0f295644
https://doi.org/10.1007/s00253-021-11102-7

Simultaneous elucidation of antibiotic mechanism of action and potency with high-throughput Fourier-transform infrared (FTIR) spectroscopy and machine learning

Autor: Bernardo, Ribeiro da Cunha, Luís P, Fonseca, Cecília R C, Calado

Publikováno v: Applied microbiology and biotechnology. 105(3)

The low rate of discovery and rapid spread of resistant pathogens have made antibiotic discovery a worldwide priority. In cell-based screening, the mechanism of action (MOA) is identified after antimicrobial activity. This increases rediscovery, impa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f960d56a94af3ca0bd1813693805e51
https://pubmed.ncbi.nlm.nih.gov/33443637

Antibiotic discovery: where have we come from, where do we go?

Autor: Cecília R.C. Calado, Bernardo Ribeiro da Cunha, Luís P. Fonseca

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Antibiotics, Vol 8, Iss 2, p 45 (2019)
Antibiotics

Given the increase in antibiotic-resistant bacteria, alongside the alarmingly low rate of newly approved antibiotics for clinical usage, we are on the verge of not having effective treatments for many common infectious diseases. Historically, antibio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240ebb437a19154abbfd625d5262d871