Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Bernardo L. Trigatti"'
Autor:
Elizabeth Balint, Emily Feng, Elizabeth C. Giles, Tyrah M. Ritchie, Alexander S. Qian, Fatemeh Vahedi, Amelia Montemarano, Ana L. Portillo, Jonathan K. Monteiro, Bernardo L. Trigatti, Ali A. Ashkar
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Although many viral infections are linked to the development of neurological disorders, the mechanism governing virus-induced neuropathology remains poorly understood, particularly when the virus is not directly neuropathic. Using a mouse mo
Externí odkaz:
https://doaj.org/article/6aeb5ccf5b17453d823de52e27ba81e0
Autor:
Christine Bassila, George E.G. Kluck, Narmadaa Thyagarajan, Kevin M. Chathely, Leticia Gonzalez, Bernardo L. Trigatti
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 5, Pp 100541- (2024)
HDLs carry sphingosine-1-phosphate (S1P) and stimulate signaling pathways in different cells including macrophages and endothelial cells, involved in atherosclerotic plaque development. HDL signaling via S1P relies on the HDL receptor scavenger recep
Externí odkaz:
https://doaj.org/article/18180c1e103147a09b199b3919316c61
Autor:
Mark T. Fuller, Omid Dadoo, Ting Xiong, Pardh Chivukula, Melissa E. MacDonald, Samuel K. Lee, Richard C. Austin, Suleiman A. Igdoura, Bernardo L. Trigatti
Publikováno v:
Frontiers in Physiology, Vol 13 (2023)
High levels of low density lipoprotein (LDL) cholesterol and low levels of high density lipoprotein (HDL) cholesterol are risk factors for cardiovascular disease. Mice that lack genes involved in the clearance of LDL from the bloodstream, such as the
Externí odkaz:
https://doaj.org/article/f8368d10c28547169382e33fdc0c0061
Autor:
Emily A. Day, Rebecca J. Ford, Brennan K. Smith, Vanessa P. Houde, Stephanie Stypa, Sonia Rehal, Sarka Lhotak, Bruce E. Kemp, Bernardo L. Trigatti, Geoff H. Werstuck, Richard C. Austin, Morgan D. Fullerton, Gregory R. Steinberg
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101321- (2021)
Objective: Salsalate is a prodrug of salicylate that lowers blood glucose in people with type 2 diabetes. AMP-activated protein kinase (AMPK) is an αβγ heterotrimer which inhibits macrophage inflammation and the synthesis of fatty acids and choles
Externí odkaz:
https://doaj.org/article/ac41af7c053648d78768cda15dc2b35a
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
Cardiovascular disease and cancer are the leading causes of death in developed societies. Despite their effectiveness, many cancer therapies exhibit deleterious cardiovascular side effects such as cardiotoxicity and heart failure. The cardiotoxic eff
Externí odkaz:
https://doaj.org/article/094439669c184bbf882a618d79fc0e6a
Publikováno v:
Data in Brief, Vol 19, Iss , Pp 1148-1161 (2018)
PDZK1 (Post-synaptic density protein/Drosophila disc-large protein/Zonula occludens protein containing 1) is an adaptor protein that binds to the HDL receptor, Scavenger receptor class B type I. Leukocyte PDZK1 deficiency in high fat-diet fed LDL rec
Externí odkaz:
https://doaj.org/article/06324b21d9184401ab542fa61c08e78f
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Diabetes is a risk factor for development of atherosclerotic cardiovascular disease. Animal model studies in mice revealed that hyperglycemia increases development of atherosclerosis in the aorta as well as myocardial fibrosis in surgical models of c
Externí odkaz:
https://doaj.org/article/02b87c3808a54194947ab0f312d6b76b
Autor:
Abraham Yang, Gabriel Gyulay, Mark Mitchell, Elizabeth White, Bernardo L. Trigatti, Suleiman A. Igdoura
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 12, Pp 2573-2585 (2012)
Lipoprotein metabolism is an important contributing factor in the development and progression of atherosclerosis. Plasma lipoproteins and their receptors are heavily glycosylated and sialylated, and levels of sialic acids modulate their biological fu
Externí odkaz:
https://doaj.org/article/055d1012c0954c8bbd71dee0021cb545
Autor:
Šárka Lhoták, Gabriel Gyulay, Jean‐Claude Cutz, Ali Al‐Hashimi, Bernardo L. Trigatti, Carl D. Richards, Suleiman A. Igdoura, Gregory R. Steinberg, Jonathan Bramson, Kjetil Ask, Richard C. Austin
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 8 (2016)
BackgroundMonocyte recruitment leads to accumulation of macrophage foam cells and contributes to atherosclerotic lesion growth. Recent studies have reported that lesion‐resident macrophages can proliferate and represent a major cellular component d
Externí odkaz:
https://doaj.org/article/33e9a1897c9f4d2ca7e2e0b90b59ad1b
Autor:
Yi Zhang, Ayesha M. Ahmed, Nicole McFarlane, Christina Capone, Douglas R. Boreham, Ray Truant, Suleiman A. Igdoura, Bernardo L. Trigatti
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 2, Pp 405-416 (2007)
Scavenger receptor, class B, type I (SR-BI) mediates binding and internalization of a variety of lipoprotein and nonlipoprotein ligands, including HDL. Studies in genetically engineered mice revealed that SR-BI plays an important role in HDL reverse
Externí odkaz:
https://doaj.org/article/c62a1a4fd66d42548e7d74e0a755757c