The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei.

Autor: Anna Kelner, Michele Tinti, Maria Lucia S Guther, Bernardo J Foth, Lia Chappell, Matthew Berriman, Victoria Haigh Cowling, Michael A J Ferguson

Publikováno v: PLoS ONE, Vol 13, Iss 7, p e0201263 (2018)

Messenger RNA is modified by the addition of a 5' methylated cap structure, which protects the transcript and recruits protein complexes that mediate RNA processing and/or the initiation of translation. Two genes encoding mRNA cap methyltransferases

Externí odkaz: https://doaj.org/article/cf2728ded2644d3ba3889d9ca86a61ea

Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome.

Autor: Deuan C Jones, Bernardo J Foth, Michael D Urbaniak, Stephen Patterson, Han B Ong, Matthew Berriman, Alan H Fairlamb

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 12, p e0004299 (2015)

SCYX-7158, an oxaborole, is currently in Phase I clinical trials for the treatment of human African trypanosomiasis. Here we investigate possible modes of action against Trypanosoma brucei using orthogonal chemo-proteomic and genomic approaches. SILA

Externí odkaz: https://doaj.org/article/74159255136f410d997c5011131409c9

Biogenesis of the inner membrane complex is dependent on vesicular transport by the alveolate specific GTPase Rab11B.

Autor: Carolina Agop-Nersesian, Saskia Egarter, Gordon Langsley, Bernardo J Foth, David J P Ferguson, Markus Meissner

Publikováno v: PLoS Pathogens, Vol 6, Iss 7, p e1001029 (2010)

Apicomplexan parasites belong to a recently recognised group of protozoa referred to as Alveolata. These protists contain membranous sacs (alveoli) beneath the plasma membrane, termed the Inner Membrane Complex (IMC) in the case of Apicomplexa. Durin

Externí odkaz: https://doaj.org/article/7d5e007436f9431e84cc736d34cfd817

Whipworm genome and dual-species transcriptome analyses provide molecular insights into an intimate host-parasite interaction

Autor: Thomas Huckvale, Alan Tracey, Adam J. Reid, Isheng J. Tsai, Sarah Nichol, Magdalena Zarowiecki, Nancy Holroyd, Richard K. Grencis, Bernardo J. Foth, Jimmy Z. Liu, James Cotton, Allison J. Bancroft, Eleanor J Stanley, Philip J. Cooper, Matthew Berriman

Publikováno v: Nature genetics

Whipworms are common soil-transmitted helminths that cause debilitating chronic infections in man. These nematodes are only distantly related to Caenorhabditis elegans and have evolved to occupy an unusual niche, tunneling through epithelial cells of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3055e04e632339b40721488905ec9816
https://doi.org/10.1038/ng.3010

The genomic basis of parasitism in the Strongyloides Glade of nematodes

Autor: Michael A. Quail, Matthew Berriman, Sarah Nichol, Adam J. Reid, Karen Brooks, Mark Viney, Isheng J. Tsai, Hayley M. Bennett, James B. Lok, Bhavana Harsha, Dee R. Denver, Helen Beasley, Adrian Streit, Norbert W. Brattig, Haruhiko Murayama, Takehiko Itoh, Diogo M Ribeiro, Avril Coghlan, Yoshitoshi Ogura, Jonathan M. Wastling, Dong Xia, Nadine Randle, James Cotton, Hanns Soblik, Tetsuya Hayashi, Eiji Nagayasu, Dorothee Harbecke, Vicky L. Hunt, Warwick N. Grant, Alan Tracey, Rei Kajitani, Nancy Holroyd, Alejandro Sanchez-Flores, Eleanor J Stanley, Bernardo J. Foth, Taisei Kikuchi, Arpita Kulkarni, Jonathan D. Stoltzfus

Publikováno v: Nature Genetics
Nature genetics
Hunt, V L, Tsai, I J, Coghlan, A, Reid, A J, Holroyd, N, Foth, B J, Tracey, A, Cotton, J A, Stanley, E J, Beasley, H, Bennett, H M, Brooks, K, Harsha, B, Kajitani, R, Kulkarni, A, Harbecke, D, Nagayasu, E, Nichol, S, Ogura, Y, Quail, M A, Randle, N, Xia, D, Brattig, N W, Soblik, H, Ribeiro, D M, Sanchez-Flores, A, Hayashi, T, Itoh, T, Denver, D R, Grant, W, Stoltzfus, J D, Lok, J B, Murayama, H, Wastling, J, Streit, A, Kikuchi, T, Viney, M & Berriman, M 2016, ' The genomic basis of parasitism in the Strongyloides clade of nematodes ', Nature Genetics, vol. 48, no. 3, pp. 299-307 . https://doi.org/10.1038/ng.3495

Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides species, including the human pathogen Strongyloides stercoralis, and their c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6590f8c580e6aa30d0d068adbeafa2a2
https://researchonline.rvc.ac.uk/id/eprint/11684/1/11684.pdf