Výsledky vyhledávání - "Bernardo Brito Palma"

Cytochrome P450 expression system for high-throughput real-time detection of genotoxicity: Application to the study of human CYP1A2 variants

Autor: Michel Kranendonk, Daniela Moutinho, José Rueff, Bernardo Brito Palma, Philippe Urban

Publikováno v: Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 806:24-33

Individual variations in cytochrome P450-mediated metabolism are believed to contribute to individual susceptibility to chemical carcinogenesis. CYP1A2 is one of the major forms of cytochrome P450 involved in drug metabolism and bioactivation of carc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca96dec64359ec9755f5fdf55d79b33d
https://doi.org/10.1016/j.mrgentox.2016.06.004

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Prototype Systems Containing Human Cytochrome P450 for High-Throughput Real-Time Detection of DNA Damage by Compounds That Form DNA-Reactive Metabolites

Autor: José Rueff, Michel Kranendonk, Bernardo Brito Palma, Charles W. Fisher

Publikováno v: Chemical Research in Toxicology. 29:747-756

The formation of reactive metabolites through biotransformation is the suspected cause of many adverse drug reactions. Testing for the propensity of a drug to form reactive metabolites has increasingly become an integral part of lead-optimization str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed9bc4d1b630b6a021681dd37df7af2
https://doi.org/10.1021/acs.chemrestox.5b00455

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Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450

Autor: Bruno Gomes, Thomas Lautier, José Rueff, Gilles Truan, Bernardo Brito Palma, Francisco de Assis Esteves, Diana Campelo, Michel Kranendonk, Philippe Urban

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 12, p 3914 (2018)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2018, 19 (12), 16 p. ⟨10.3390/ijms19123914⟩
International Journal of Molecular Sciences, MDPI, 2018, 19 (12), 16 p. ⟨10.3390/ijms19123914⟩
International Journal of Molecular Sciences 12 (19), 16 p.. (2018)
Volume 19
Issue 12
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

NADPH-cytochrome P450 reductase (CPR) is the unique redox partner of microsomal cytochrome P450s (CYPs). CPR exists in a conformational equilibrium between open and closed conformations throughout its electron transfer (ET) function. Previously, we h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749fe5eae7fea6ba725992f9caf7032f
https://www.mdpi.com/1422-0067/19/12/3914

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Escherichia coli BTC, a human cytochrome P450 competent tester strain with a high sensitivity towards alkylating agents: involvement of alkyltransferases in the repair of DNA damage induced by aromatic amines

Autor: José Santos Oliveira, António Laires, Bernardo Brito Palma, Michel Kranendonk, Maria Paula Amaro de Castilho Duarte, José Rueff

Publikováno v: Mutagenesis. 20:199-208

We report here on strain BTC, a new Escherichia coli mutagenicity tester strain for the expression of human cytochrome P450 (CYP) with an enhanced sensitivity for the detection of alkylating agents. This strain was developed first through knocking ou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127e7bd9d64a8bdaf223a79f091b7b78
https://doi.org/10.1093/mutage/gei028

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Functional characterization of eight human CYP1A2 variants: the role of cytochrome b(5)

Autor: Bernardo Brito Palma, Michel Kranendonk, Phillipe Urban, José Rueff, Marta Silva e Sousa

Publikováno v: Pharmacogenetics and Genomics
Pharmacogenetics and Genomics, Lippincott, Williams & Wilkins, 2013, 23 (2), pp.41-68. ⟨10.1097/FPC.0b013e32835c2ddf⟩
Pharmacogenetics and Genomics, 2013, 23 (2), pp.41-68. ⟨10.1097/FPC.0b013e32835c2ddf⟩

Background Interindividual variability in cytochrome P450 (CYP)-mediated xenobiotic metabolism is extensive. CYP metabolism requires two electrons, which can be donated by NADPH cytochrome P450 oxidoreductase (CYPOR) and/or cytochrome b5 (b5). Althou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b51441c9481c30a540d36f4be2bb0c5
https://hal.archives-ouvertes.fr/hal-01268206

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Alkylating potential of oxetanes

Autor: José Rueff, Célia Martins, Michel Kranendonk, Rafael Gómez-Bombarelli, Emilio Calle, António Sebastião Rodrigues, Bernardo Brito Palma, Julio Casado

Publikováno v: Chemical research in toxicology. 23(7)

Small, highly strained heterocycles are archetypical alkylating agents (oxiranes, beta-lactones, aziridinium, and thiirinium ions). Oxetanes, which are tetragonal ethers, are higher homologues of oxiranes and reduced counterparts of beta-lactones, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8baf7c1cd2ef2f0e2398b395fca1b722
https://pubmed.ncbi.nlm.nih.gov/20550097

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