Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Bernardina Scafuri"'
Autor:
Luana Licata, Allegra Via, Paola Turina, Giulia Babbi, Silvia Benevenuta, Claudio Carta, Rita Casadio, Andrea Cicconardi, Angelo Facchiano, Piero Fariselli, Deborah Giordano, Federica Isidori, Anna Marabotti, Pier Luigi Martelli, Stefano Pascarella, Michele Pinelli, Tommaso Pippucci, Roberta Russo, Castrense Savojardo, Bernardina Scafuri, Lucrezia Valeriani, Emidio Capriotti
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Collectively, rare genetic disorders affect a substantial portion of the world’s population. In most cases, those affected face difficulties in receiving a clinical diagnosis and genetic characterization. The understanding of the molecular mechanis
Externí odkaz:
https://doaj.org/article/11124e19b5df45e0a5d0ff3484da618c
Autor:
Deborah Giordano, Bernardina Scafuri, Luigi De Masi, Lucia Capasso, Viviana Maresca, Lucia Altucci, Angela Nebbioso, Angelo Facchiano, Paola Bontempo
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1624 (2023)
Epigenetic mechanisms finely regulate gene expression and represent potential therapeutic targets. Cambinol is a synthetic heterocyclic compound that inhibits class III histone deacetylases known as sirtuins (SIRTs). The acetylating action that resul
Externí odkaz:
https://doaj.org/article/1fc1cc3f519e4798a9c3155b98182a52
Publikováno v:
BMC Bioinformatics, Vol 22, Iss S7, Pp 1-19 (2021)
Abstract Background Despite decades on developing dedicated Web tools, it is still difficult to predict correctly the changes of the thermodynamic stability of proteins caused by mutations. Here, we assessed the reliability of five recently developed
Externí odkaz:
https://doaj.org/article/795cbbb02cd44ee8baa8efdcf789fc46
Autor:
Nancy D’Arminio, Deborah Giordano, Bernardina Scafuri, Carmen Biancaniello, Mauro Petrillo, Angelo Facchiano, Anna Marabotti
Publikováno v:
Molecules, Vol 27, Iss 15, p 4827 (2022)
The SARS-CoV-2 variant Omicron is characterized, among others, by more than 30 amino acid changes occurring on the spike glycoprotein with respect to the original SARS-CoV-2 spike protein. We report a comprehensive analysis of the effects of the Omic
Externí odkaz:
https://doaj.org/article/46940e3075d4404493cb077d9ae072e2
Autor:
Carmen Biancaniello, Antonia D’Argenio, Deborah Giordano, Serena Dotolo, Bernardina Scafuri, Anna Marabotti, Antonio d’Acierno, Roberto Tagliaferri, Angelo Facchiano
Publikováno v:
Molecules, Vol 27, Iss 5, p 1747 (2022)
Human menin is a nuclear protein that participates in many cellular processes, as transcriptional regulation, DNA damage repair, cell signaling, cell division, proliferation, and migration, by interacting with many other proteins. Mutations of the ge
Externí odkaz:
https://doaj.org/article/f1d231b308c54b6094a90bb1e347c12e
Autor:
Anna Verdino, Gaetano D’Urso, Carmen Tammone, Bernardina Scafuri, Lucrezia Catapano, Anna Marabotti
Publikováno v:
Molecules, Vol 26, Iss 19, p 6061 (2021)
Classic galactosemia is an inborn error of metabolism associated with mutations that impair the activity and the stability of galactose-1-phosphate uridylyltransferase (GALT), catalyzing the third step in galactose metabolism. To date, no treatments
Externí odkaz:
https://doaj.org/article/40301b4700584dfc948b59692b3ba2f7
Publikováno v:
Molecules, Vol 26, Iss 19, p 5941 (2021)
The third step of the catabolism of galactose in mammals is catalyzed by the enzyme galactose-1-phosphate uridylyltransferase (GALT), a homodimeric enzyme with two active sites located in the proximity of the intersubunit interface. Mutations of this
Externí odkaz:
https://doaj.org/article/7fdb365078914da3b22ed268f2b71808
Publikováno v:
Biomedicines, Vol 8, Iss 12, p 568 (2020)
Histone modifications through acetylation are fundamental for remodelling chromatin and consequently activating gene expression. The imbalance between acetylation and deacetylation activity causes transcriptional dysregulation associated with several
Externí odkaz:
https://doaj.org/article/b1b99fae6b73416f8ede5b365d820151
Autor:
Bontempo, Deborah Giordano, Bernardina Scafuri, Luigi De Masi, Lucia Capasso, Viviana Maresca, Lucia Altucci, Angela Nebbioso, Angelo Facchiano, Paola
Publikováno v:
Biomedicines; Volume 11; Issue 6; Pages: 1624
Epigenetic mechanisms finely regulate gene expression and represent potential therapeutic targets. Cambinol is a synthetic heterocyclic compound that inhibits class III histone deacetylases known as sirtuins (SIRTs). The acetylating action that resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::c20ff7d80d3a342758b9909888cd5bbd
Publikováno v:
Trends in Biochemical Sciences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c625c5a73c4e08149d312844d630957f
https://doi.org/10.1016/j.tibs.2023.03.002
https://doi.org/10.1016/j.tibs.2023.03.002