Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Bernardes GJ"'
Autor:
Lopes Bernardes, GJ
Photo-activated drugs provide an opportunity to improve efficacy alongside reducing side-effects in the treatment of severe diseases, such as cancer. Herein, we describe a photoactivation decaging method of isobutylene-caged thiols through a UV-initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9d9e580eb45f906c8ed56e6cd6402d
https://www.repository.cam.ac.uk/handle/1810/285696
https://www.repository.cam.ac.uk/handle/1810/285696
Autor:
Martínez-Sáez, N, Sun, S, Oldrini, D, Sormanni, P, Boutureira, O, Carboni, F, Compañón, I, Deery, MJ, Vendruscolo, M, Corzana, F, Adamo, R, Lopes Bernardes, GJ
Here we show that a four-membered oxygen ring – oxetane – can be readily grafted into native peptides and proteins through site-selective bis-alkylation of cysteine residues present as disulfides under mild and biocompatible conditions. The selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a866f17bc580fff402e6c93a1cc2eb
https://www.repository.cam.ac.uk/handle/1810/273533
https://www.repository.cam.ac.uk/handle/1810/273533
Autor:
Lopes Bernardes, GJ
Mercury pollution threatens the environment and human health across the globe. This neurotoxic substance is encountered in artisanal gold mining, coal combustion, oil and gas refining, waste incineration, chloralkali plant operation, metallurgy, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58e206838f8ef09288e3f8c156221ff
Autor:
Somovilla, VJ, Bermejo, IA, Albuquerque, IS, Martínez-Sáez, N, Castro-López, J, García-Martín, F, Compañón, I, Hinou, H, Nishimura, S, Jiménez-Barbero, J, Asensio, JL, Avenoza, A, Busto, Hurtado-Guerrero, R, Peregrina, JM, Lopes Bernardes, GJ, Corzana1, F
A structure-based design of a new gene22ration tumor-associated glycopeptides with improved affinity against two anti-MUC1 antibodies is described. These unique antigens feature a fluorinated proline residue, such as a (4S)-4-fluoro-L-proline or 4,4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5ac8b256bc36700541e187fd83ca012
Oxetanes are four-membered ring oxygen heterocycles that are advantageously used in medicinal chemistry as modulators of physicochemical properties of small molecules. Herein, we present a simple method for the incorporation of oxetanes into proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::add9f4d9bfb5d9754c035060b7c1be85
Autor:
Pereira MM; Obesity Laboratory, Instituto Gulbenkian de Ciência, Oeiras 2780-156, Portugal., Mahú I; Obesity Laboratory, Instituto Gulbenkian de Ciência, Oeiras 2780-156, Portugal., Seixas E; Obesity Laboratory, Instituto Gulbenkian de Ciência, Oeiras 2780-156, Portugal., Martinéz-Sánchez N; NeurObesity Group, Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela (A Coruña) 15782, Spain.; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela 15706, Spain., Kubasova N; Obesity Laboratory, Instituto Gulbenkian de Ciência, Oeiras 2780-156, Portugal., Pirzgalska RM; Obesity Laboratory, Instituto Gulbenkian de Ciência, Oeiras 2780-156, Portugal., Cohen P; Laboratory of Molecular Metabolism, The Rockefeller University, New York, New York 10065, USA., Dietrich MO; Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.; Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06520, USA., López M; NeurObesity Group, Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela (A Coruña) 15782, Spain.; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela 15706, Spain., Bernardes GJ; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.; Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa 1649-028, Portugal., Domingos AI; Obesity Laboratory, Instituto Gulbenkian de Ciência, Oeiras 2780-156, Portugal.
Publikováno v:
Nature communications [Nat Commun] 2017 Apr 03; Vol. 8, pp. 14967. Date of Electronic Publication: 2017 Apr 03.
Autor:
Cal PM; a Department of Chemistry , University of Cambridge , Cambridge , United Kingdom.; b Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa , Lisboa , Portugal., Matos MJ; a Department of Chemistry , University of Cambridge , Cambridge , United Kingdom., Bernardes GJ; a Department of Chemistry , University of Cambridge , Cambridge , United Kingdom.; b Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa , Lisboa , Portugal.
Publikováno v:
Expert opinion on therapeutic patents [Expert Opin Ther Pat] 2017 Feb; Vol. 27 (2), pp. 179-189. Date of Electronic Publication: 2016 Nov 23.
Autor:
Jiménez-Moreno E; Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK., Guo Z; Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK., Oliveira BL; Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK., Albuquerque IS; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisboa, Portugal., Kitowski A; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisboa, Portugal., Guerreiro A; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisboa, Portugal., Boutureira O; Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK., Rodrigues T; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisboa, Portugal., Jiménez-Osés G; Departamento de Química, Universidad de La Rioja, Centro de Investigación en Síntesis Química, 26006, Logroño, Spain.; Institute of Biocomputation and Physics of Complex Systems (BIFI), University of Zaragoza, BIFI-IQFR (CSIC), Zaragoza, Spain., Bernardes GJ; Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK.; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisboa, Portugal.
Publikováno v:
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2017 Jan 02; Vol. 56 (1), pp. 243-247. Date of Electronic Publication: 2016 Dec 08.
Autor:
Cal PM; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisboa, Portugal. gbernardes@medicina.ulisboa.pt and Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK. gb453@cam.ac.uk., Sieglitz F; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisboa, Portugal. gbernardes@medicina.ulisboa.pt., Santos FM; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisboa, Portugal. pedrogois@ff.ul.pt., Parente Carvalho C; CIQSO - Center for Research in Sustainable Chemistry and Department of Chemistry, University of Huelva, Campus de El Carmen s/n, 21071 Huelva, Spain., Guerreiro A; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisboa, Portugal. gbernardes@medicina.ulisboa.pt., Bertoldo JB; Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK. gb453@cam.ac.uk., Pischel U; CIQSO - Center for Research in Sustainable Chemistry and Department of Chemistry, University of Huelva, Campus de El Carmen s/n, 21071 Huelva, Spain., Gois PM; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisboa, Portugal. pedrogois@ff.ul.pt., Bernardes GJ; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisboa, Portugal. gbernardes@medicina.ulisboa.pt and Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK. gb453@cam.ac.uk.
Publikováno v:
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2016 Dec 22; Vol. 53 (2), pp. 368-371.
Autor:
Rodrigues T; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal., Bernardes GJ; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal.; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Publikováno v:
Nature chemistry [Nat Chem] 2016 Nov 22; Vol. 8 (12), pp. 1088-1090.