Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Bernard de Massy"'
Autor:
Akbar Zainu, Pauline Dupaigne, Soumya Bouchouika, Julien Cau, Julie A. J. Clément, Pauline Auffret, Virginie Ropars, Jean-Baptiste Charbonnier, Bernard de Massy, Raphael Mercier, Rajeev Kumar, Frédéric Baudat
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract During meiosis, nucleoprotein filaments of the strand exchange proteins RAD51 and DMC1 are crucial for repairing SPO11-generated DNA double-strand breaks (DSBs) by homologous recombination (HR). A balanced activity of positive and negative R
Externí odkaz:
https://doaj.org/article/b23ba1e45f564ac9871d10aea2621def
Autor:
Alexandre Nore, Ariadna B. Juarez-Martinez, Julie Clément, Christine Brun, Boubou Diagouraga, Hamida Laroussi, Corinne Grey, Henri Marc Bourbon, Jan Kadlec, Thomas Robert, Bernard de Massy
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
TOPOVIBL and REC114 are required for meiotic DNA double-strand breaks (DSBs). This study shows that TOPOVIBL forms a complex with REC114 and mice carrying mutations that disrupt the interaction show DSB defects with distinct outcomes in males and fem
Externí odkaz:
https://doaj.org/article/42062dd602864b3f8af026b5628cdb49
Autor:
Corinne Grey, Bernard de Massy
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
One of the most fascinating aspects of meiosis is the extensive reorganization of the genome at the prophase of the first meiotic division (prophase I). The first steps of this reorganization are observed with the establishment of an axis structure,
Externí odkaz:
https://doaj.org/article/17c592127fa5427b9afb11a61c68ab3c
Autor:
Yukiko Imai, Mathilde Biot, Julie AJ Clément, Mariko Teragaki, Serge Urbach, Thomas Robert, Frédéric Baudat, Corinne Grey, Bernard de Massy
Publikováno v:
eLife, Vol 9 (2020)
Meiotic recombination starts with the formation of DNA double-strand breaks (DSBs) at specific genomic locations that correspond to PRDM9-binding sites. The molecular steps occurring from PRDM9 binding to DSB formation are unknown. Using proteomic ap
Externí odkaz:
https://doaj.org/article/854848377549491da558312ea21dbe9c
Autor:
Mathilde Biot, Bernard de Massy
Publikováno v:
eLife, Vol 9 (2020)
Three independent studies show that a protein called ZCWPW1 is able to recognize the histone modifications that initiate the recombination of genetic information during meiosis.
Externí odkaz:
https://doaj.org/article/0117797199294245b4886898ad3ca554
Publikováno v:
PLoS Genetics, Vol 14, Iss 8, p e1007479 (2018)
During meiosis, maternal and paternal chromosomes undergo exchanges by homologous recombination. This is essential for fertility and contributes to genome evolution. In many eukaryotes, sites of meiotic recombination, also called hotspots, are region
Externí odkaz:
https://doaj.org/article/3e426d5e45f94d1f986c4c7eaebb8b04
Autor:
Julie Clément, Bernard de Massy
Publikováno v:
eLife, Vol 6 (2017)
The ways in which recombination sites are determined during meiosis are becoming clearer following a phylogenomic analysis for 225 different species.
Externí odkaz:
https://doaj.org/article/9c90dd2c20a84e8481b3419aba8a597b
Autor:
Hong Wu, Nikolas Mathioudakis, Boubou Diagouraga, Aiping Dong, Ludmila Dombrovski, Frédéric Baudat, Stephen Cusack, Bernard de Massy, Jan Kadlec
Publikováno v:
Cell Reports, Vol 5, Iss 1, Pp 13-20 (2013)
PRDM9, a histone lysine methyltransferase, is a key determinant of the localization of meiotic recombination hot spots in humans and mice and the only vertebrate protein known to be involved in hybrid sterility. Here, we report the crystal structure
Externí odkaz:
https://doaj.org/article/441a5c8c07ee4339885fc3874938ebc6
Autor:
Magali Soumillon, Anamaria Necsulea, Manuela Weier, David Brawand, Xiaolan Zhang, Hongcang Gu, Pauline Barthès, Maria Kokkinaki, Serge Nef, Andreas Gnirke, Martin Dym, Bernard de Massy, Tarjei S. Mikkelsen, Henrik Kaessmann
Publikováno v:
Cell Reports, Vol 3, Iss 6, Pp 2179-2190 (2013)
Understanding the extent of genomic transcription and its functional relevance is a central goal in genomics research. However, detailed genome-wide investigations of transcriptome complexity in major mammalian organs have been scarce. Here, using ex
Externí odkaz:
https://doaj.org/article/3b97df133e8f4989a02efd975a6ac3af
Autor:
Jérôme Buard, Eric Rivals, Denis Dunoyer de Segonzac, Charlotte Garres, Pierre Caminade, Bernard de Massy, Pierre Boursot
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85021 (2014)
In humans and mice, meiotic recombination events cluster into narrow hotspots whose genomic positions are defined by the PRDM9 protein via its DNA binding domain constituted of an array of zinc fingers (ZnFs). High polymorphism and rapid divergence o
Externí odkaz:
https://doaj.org/article/3818ccc7bb294c9f835953726ac9e426