Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Bernard Wuensch"'
Autor:
Caterina Zanette, Mariangela Urbano, Alice Pedrali, Christian Laggner, Maria Grazia Mamolo, Bernard Wuensch, Massimo Serra, Ornella Azzolina, Daniele Zampieri, Simona Collina, Dirk Schepmann, Daniela Rossi, Chiara Florio
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:771-783
A new series of arylalkyl- and alkenylamines was designed, synthesized, and evaluated for binding to sigma(1) and sigma(2) receptors. Many compounds exhibited nanomolar affinity for sigma(1) subtype receptor with good selectivity over sigma(2). A mol
Autor:
Daniela Rossi, Mariangela Urbano, Alice Pedrali, Massimo Serra, Daniele Zampieri, Maria Grazia Mamolo, Christian Laggner, Caterina Zanette, Chiara Florio, Dirk Schepmann, Bernard Wuensch, Ornella Azzolina, Simona Collina
Publikováno v:
Bioorganicmedicinal chemistry. 18(3)
In order to investigate the molecular features involved in sigma receptors (sigma-Rs) binding, new compounds based on arylalkylaminoalcoholic, arylalkenyl- and arylalkylaminic scaffolds were synthesized and their affinity towards sigma(1)- and sigma(