Zobrazeno 1 - 10
of 249
pro vyhledávání: '"Bernard Thébaud"'
Autor:
Manoj M. Lalu, Dawn Richards, Madison Foster, Brittany French, Angela M. Crawley, Kirsten M. Fiest, Kathryn Hendrick, Kimberly F. Macala, Asher A. Mendelson, Pat Messner, Stuart G. Nicholls, Justin Presseau, Cheryle A. Séguin, Patrick Sullivan, Bernard Thébaud, Dean A. Fergusson
Publikováno v:
Research Involvement and Engagement, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Background Patient engagement in research is the meaningful and collaborative interaction between patients and researchers throughout the research process. Patient engagement can help to ensure patient-oriented values and perspectives are in
Externí odkaz:
https://doaj.org/article/d1346b77fe94404e9245270fe80b7977
Autor:
Austin D. Read, Rachel E. T. Bentley, Ashley Y. Martin, Jeffrey D. Mewburn, Elahe Alizadeh, Danchen Wu, Patricia D. A. Lima, Kimberly J. Dunham‐Snary, Bernard Thébaud, Willard Sharp, Stephen L. Archer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 13 (2023)
Background As partial pressure of oxygen (pO2) rises with the first breath, the ductus arteriosus (DA) constricts, diverting blood flow to the pulmonary circulation. The DA's O2 sensor resides within smooth muscle cells. The DA smooth muscle cells’
Externí odkaz:
https://doaj.org/article/e030b967cfd24d6397635a590b09f624
Autor:
Marissa A. Lithopoulos, Xavier Toussay, Shumei Zhong, Liqun Xu, Shamimunisa B. Mustafa, Julie Ouellette, Moises Freitas-Andrade, Cesar H. Comin, Hayam A. Bassam, Adam N. Baker, Yiren Sun, Michael Wakem, Alvaro G. Moreira, Cynthia L. Blanco, Arul Vadivel, Catherine Tsilfidis, Steven R. Seidner, Ruth S. Slack, Diane C. Lagace, Jing Wang, Baptiste Lacoste, Bernard Thébaud
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 22 (2022)
Preterm birth is the leading cause of death in children under 5 years of age. Premature infants who receive life-saving oxygen therapy often develop bronchopulmonary dysplasia (BPD), a chronic lung disease. Infants with BPD are at a high risk of abno
Externí odkaz:
https://doaj.org/article/b460101f4de54091bba25914881e2839
Autor:
Bernard Thébaud, Manoj Lalu, Laurent Renesme, Sasha vanKatwyk, Justin Presseau, Kednapa Thavorn, Kelly D. Cobey, Brian Hutton, David Moher, Roger F. Soll, Dean Fergusson
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 7, Pp 968-975 (2021)
Abstract Cell‐based therapies hold promise to substantially curb complications from extreme preterm birth, the main cause of death in children below the age of 5 years. Exciting preclinical studies in experimental neonatal lung injury have provided
Externí odkaz:
https://doaj.org/article/2791354e597442ad92ae5be3758ae715
Autor:
Maria Hurskainen, Ivana Mižíková, David P. Cook, Noora Andersson, Chanèle Cyr-Depauw, Flore Lesage, Emmi Helle, Laurent Renesme, Robert P. Jankov, Markku Heikinheimo, Barbara C. Vanderhyden, Bernard Thébaud
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
It is unclear how changes in gene expression are induced by changes in oxygen levels during late lung development. Here, the authors provide data from MULTI-seq scRNAseq in mice showing exposure to higher oxygen levels affects cell fates, especially
Externí odkaz:
https://doaj.org/article/f32cc8aebe874074a51d470766b32ce0
Autor:
Martin H. Kang, Laura P. van Lieshout, Liqun Xu, Jakob M. Domm, Arul Vadivel, Laurent Renesme, Christian Mühlfeld, Maria Hurskainen, Ivana Mižíková, Yanlong Pei, Jacob P. van Vloten, Sylvia P. Thomas, Claudia Milazzo, Chanèle Cyr-Depauw, Jeffrey A. Whitsett, Lawrence M. Nogee, Sarah K. Wootton, Bernard Thébaud
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Surfactant protein B (SP-B) deficiency is a genetic lung disease that results in lethal respiratory distress within months of birth. Here, the authors describe a gene therapy strategy using a rationally designed AAV6 capsid that restores surfactant h
Externí odkaz:
https://doaj.org/article/6438f94f53b5451b8361dfa466593f2a
Publikováno v:
BMC Pediatrics, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background Bronchopulmonary dysplasia (BPD) is among the most severe chronic lung diseases and predominantly affects premature infants. There is a general understanding of BPD’s significant impact on the short-term outcomes however there i
Externí odkaz:
https://doaj.org/article/8f929cfb53fd46868d2fcbf3a4c65e43
Autor:
Sajit Augustine, Wei Cheng, Marc T. Avey, Monica L. Chan, Srinivasa Murthy Chitra Lingappa, Brian Hutton, Bernard Thébaud
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 2, Pp 158-168 (2020)
Abstract Regenerative stem cell‐based therapies for bronchopulmonary dysplasia (BPD), the most common preterm birth complication, demonstrate promise in animals. Failure to objectively appraise available preclinical data and identify knowledge gaps
Externí odkaz:
https://doaj.org/article/c48f62d9c8964e7980a7667dc62a73a0
Autor:
Rachel E.T. Bentley, Charles C.T. Hindmarch, Kimberly J. Dunham-Snary, Brooke Snetsinger, Jeffrey D. Mewburn, Arthur Thébaud, Patricia D.A. Lima, Bernard Thébaud, Stephen L. Archer
Publikováno v:
Data in Brief, Vol 40, Iss , Pp 107736- (2022)
The Ductus Arteriosus (DA) is a fetal vessel that connects the aorta to the pulmonary artery ensuring that placental oxygenated blood is diverted from the lungs to the systemic circulation. Following exposure to oxygen (O2), in the first few days of
Externí odkaz:
https://doaj.org/article/04185031aa114efe97edd725190351e2
Publikováno v:
BMJ Open, Vol 11, Iss 10 (2021)
Introduction Despite being more than two decades of research, mesenchymal stromal cell (MSC) treatments are still struggling to cross the translational gap. Two key issues that likely contribute to these failures are (1) the lack of clear definition
Externí odkaz:
https://doaj.org/article/e3ff63deed1b4505a39b31432a45fd8b