Zobrazeno 1 - 10 of 64 pro vyhledávání: '"Bernard T, Drumm"'
1
Akademický článek
Automated denoising software for calcium imaging signals using deep learning
Autor: Sharif Amit Kamran, Hussein Moghnieh, Khondker Fariha Hossain, Allison Bartlett, Alireza Tavakkoli, Bernard T. Drumm, Kenton M. Sanders, Salah A. Baker
Publikováno v: Heliyon, Vol 10, Iss 21, Pp e39574- (2024)
Dynamic Ca2+ signaling is crucial for cell survival and death, and Ca2+ imaging approaches are commonly used to study and measure cellular Ca2+ patterns within cells. However, the presence of image noise from instrumentation and experimentation proto
Externí odkaz: https://doaj.org/article/6b58be84b756423d8cae8f266c925f39
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2
Akademický článek
Ca2+‐activated Cl− channels (TMEM16A) underlie spontaneous electrical activity in isolated mouse corpus cavernosum smooth muscle cells
Autor: Xin Rui Lim, Bernard T. Drumm, Gerard P. Sergeant, Mark A. Hollywood, Keith D. Thornbury
Publikováno v: Physiological Reports, Vol 10, Iss 22, Pp n/a-n/a (2022)
Abstract Penile detumescence is maintained by tonic contraction of corpus cavernosum smooth muscle cells (CCSMC), but the underlying mechanisms have not been fully elucidated. The purpose of this study was to characterize the mechanisms underlying ac
Externí odkaz: https://doaj.org/article/65e14dfb4a29496c830ddbc1ddc76622
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3
Akademický článek
Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon
Autor: Salah A Baker, Wesley A Leigh, Guillermo Del Valle, Inigo F De Yturriaga, Sean M Ward, Caroline A Cobine, Bernard T Drumm, Kenton M Sanders
Publikováno v: eLife, Vol 10 (2021)
Interstitial cells of Cajal (ICC) generate pacemaker activity responsible for phasic contractions in colonic segmentation and peristalsis. ICC along the submucosal border (ICC-SM) contribute to mixing and more complex patterns of colonic motility. We
Externí odkaz: https://doaj.org/article/df4a3be70d6747c38f6b141798f6b25d
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5
Akademický článek
Na+/Ca2 + Exchange and Pacemaker Activity of Interstitial Cells of Cajal
Autor: Haifeng Zheng, Bernard T. Drumm, Mei Hong Zhu, Yeming Xie, Kate E. O’Driscoll, Salah A. Baker, Brian A. Perrino, Sang Don Koh, Kenton M. Sanders
Publikováno v: Frontiers in Physiology, Vol 11 (2020)
Interstitial cells of Cajal (ICC) are pacemaker cells that generate electrical slow waves in gastrointestinal (GI) smooth muscles. Slow waves organize basic motor patterns, such as peristalsis and segmentation in the GI tract. Slow waves depend upon
Externí odkaz: https://doaj.org/article/e4bfb74ddf7a4fa28f3b24effc9b71b8
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6
Calcium transients in intramuscular interstitial cells of Cajal of the murine gastric fundus and their regulation by neuroeffector transmission
Autor: Sung Jin Hwang, Bernard T. Drumm, Min Kyung Kim, Ju Hyeong Lyu, Sal Baker, Kenton M. Sanders, Sean M. Ward
Publikováno v: The Journal of Physiology. 600:4439-4463
Enteric neurotransmission is critical for coordinating motility throughout the gastrointestinal (GI) tract. However, there is considerable controversy regarding the cells that are responsible for the transduction of these neural inputs. In the presen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13d684878c8ef2da7eaf91478f2100d
https://doi.org/10.1113/jp282876
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7
Insights on gastrointestinal motility through the use of optogenetic sensors and actuators
Autor: Bernard T. Drumm, Caroline A. Cobine, Salah A. Baker
Publikováno v: J Physiol
The muscularis of the gastrointestinal (GI) tract consists of smooth muscle cells (SMCs) and various populations of interstitial cells of Cajal (ICC), platelet-derived growth factor receptor α(+) (PDGFRα(+)) cells, as well as excitatory and inhibit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5115635a6bcef66a9db038e399f8fb
https://doi.org/10.1113/jp281930
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8
The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells
Autor: Ritu Dwivedi, Bernard T. Drumm, Tuleen Alkawadri, S. Lorraine Martin, Gerard P. Sergeant, Mark A. Hollywood, Keith D. Thornbury
Publikováno v: Dwivedi, R, Drumm, B T, Alkawadri, T, Martin, S L, Sergeant, G P, Hollywood, M A & Thornbury, K D 2023, ' The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca 2+-release in mouse bronchial smooth muscle cells ', European Journal of Pharmacology, vol. 947, 175677 . https://doi.org/10.1016/j.ejphar.2023.175677
We investigated effects of TMEM16A blockers benzbromarone, MONNA, CaCCinhA01 and Ani9 on isometric contractions in mouse bronchial rings and on intracellular calcium in isolated bronchial myocytes. Separate concentrations of carbachol (0.1–10 μM)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970f8b29221c6dede4fba8316c3995f1
https://pure.qub.ac.uk/en/publications/09aae45e-017b-43c4-8e65-676a736699ee
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10
Ca
Autor: Kenton M, Sanders, Salah A, Baker, Bernard T, Drumm, Masaaki, Kurahashi
Publikováno v: Advances in experimental medicine and biology. 1383
Years ago gastrointestinal motility was thought to be due to interactions between enteric nerves and smooth muscle cells (SMCs) in the tunica muscularis. Thus, regulatory mechanisms controlling motility were either myogenic or neurogenic. Now we know
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::33443ec33c053c06994dfc4ac4cebdec
https://pubmed.ncbi.nlm.nih.gov/36587162
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