Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Bernard Riss"'
Autor:
Fei Zhongbo, Darija Dedic, Philipp Lustenberger, Ueli Rüegger, Christian Mathes, Matthias Napp, Kurt Königsberger, Bernard Riss, Thierry Schlama, Glen Dempsey, Carolien den Reijer, Lukas Hueber
Publikováno v:
European Journal of Organic Chemistry. 2021:4490-4494
A novel and concise synthesis towards DP2 receptor antagonist Fevipiprant (NVS-QAW039) was developed. The initial research route was suffering from lengthy access to the functionalized 7-aza-indole core followed by a low selective N(1)-alkylation wit
Autor:
Jialiang Li, Lei Li, Chao Ye, Laurin Wimmer, Michael Parmentier, Bernard Riss, Hongyong Kim, Tobias Kapferer
Publikováno v:
Synthesis. 50:2027-2032
Substituted benzothiazoles play an important role in medicinal chemistry due to their pharmacological properties. Their 2-substituted derivatives are often prepared from 2-chlorobenzothiazoles, which in turn can be synthesized from the 2-mercapto pre
Autor:
Patricia Podsiadly, Marion Garreau, Nicolas Berton, Prisca Fricero, Bernard Riss, Sophie Buchter
Publikováno v:
Tetrahedron. 73:3202-3212
The absolute configuration of bisabolangelone has been established by an eleven step total synthesis of the corresponding TMS protected antipode starting from (R)-(+)-pulegone. Comparison of the TMS-derivatives by GC on a chiral column, allowed us to
Autor:
Feng Sun, David Thomas Parker, Friedrich Schuerch, Silvio Roggo, Xiaolin Li, Zachary Kevin Sweeney, Li Cao, Nicole Meier, Bernard Riss, Christian Guenat, Wei Li, Zhaobo Gao, Jiping Fu, Jibin Zhao, Subramanian Karur, Wang Ruidong, Andrew H. Weiss, Regis Denay, Alexey Rivkin, Su Xu, Harald Schroeder, Michael Paul Capparelli, Simon Ng, Quanbing Wu, Xin Xiong, Weikuan Li, Wosenu Mergo, Christopher Becker, Robert Lowell Simmons, Amy Lu, Gai Yu, Wenjian Xu, Peichao Lu, Nicolas Wenger, Christian Zürcher, Thomas Lochmann, Meiliana Tjandra, Alexandre Luneau, Hongyong Kim, Aregahegn Yifru, Yunshan Peng, Fabrice Gallou, Jianguang Zhou, Roger Aki Fujimoto, Michael Wang
Publikováno v:
Bioorganicmedicinal chemistry. 26(4)
Synthetic modification of cyclosporin A at P3-P4 positions led to the discovery of NIM258, a next generation cyclophilin inhibitor with excellent anti-hepatitis C virus potency, with decreased transporter inhibition, and pharmacokinetics suitable for
Publikováno v:
Tetrahedron: Asymmetry. 11:2231-2237
Protected β-homolysine of high enantiomeric purity (ee>99.5%) is prepared utilizing the stereoselective conjugate addition of lithiated ( S )-(α-methylbenzyl)benzylamide to ( E )-7-(tosyloxy)hept-2-enoic acid tert -butyl ester, followed by subseque