Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy

Autor: Irene Pachón-Angona, Bernard Refouvelet, Rudolf Andrýs, Helène Martin, Vincent Luzet, Isabel Iriepa, Ignacio Moraleda, Daniel Diez-Iriepa, María-Jesús Oset-Gasque, José Marco-Contelles, Kamil Musilek, Lhassane Ismaili

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 479-489 (2019)

We describe herein the design, multicomponent synthesis and biological studies of new donepezil + chromone + melatonin hybrids as potential agents for Alzheimer’s disease (AD) therapy. We have identified compound 14n as promising multitarget small

Externí odkaz: https://doaj.org/article/0bac54c2f9864ac794fb57250198766b

Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives

Autor: Irene Pachón Angona, Helene Martin, Solene Daniel, Ignacio Moraleda, Alexandre Bonet, Artur Wnorowski, Maciej Maj, Krzysztof Jozwiak, Isabel Iriepa, Bernard Refouvelet, José Marco-Contelles, Lhassane Ismaili

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 20, p 7652 (2020)

We report herein the design, synthesis, biological evaluation, and molecular modelling of new inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), able to block Ca+2 channels also showing antioxidant and neuroprotective activi

Externí odkaz: https://doaj.org/article/5b73fff50c8c4937a77a76dd85a55f53

Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels

Autor: Irene Pachòn Angona, Solene Daniel, Helene Martin, Alexandre Bonet, Artur Wnorowski, Maciej Maj, Krzysztof Jóźwiak, Tiago Barros Silva, Bernard Refouvelet, Fernanda Borges, José Marco-Contelles, Lhassane Ismaili

Publikováno v: Molecules, Vol 25, Iss 6, p 1329 (2020)

We report herein the design, synthesis and biological evaluation of new antioxidant and neuroprotective multitarget directed ligands (MTDLs) able to block Ca2+ channels. New dialkyl 2,6-dimethyl-4-(4-(prop-2-yn-1-yloxy)phenyl)-1,4-dihydropyridine-3,5

Externí odkaz: https://doaj.org/article/5b1ff1d189734033aeb82bc9f2efc13b

Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer’s Disease Treatment

Autor: Ismaili, Imen Dakhlaoui, Paul J. Bernard, Diana Pietrzak, Alexey Simakov, Maciej Maj, Bernard Refouvelet, Arnaud Béduneau, Raphaël Cornu, Krzysztof Jozwiak, Fakher Chabchoub, Isabel Iriepa, Helene Martin, José Marco-Contelles, Lhassane

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9742

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease that has a heavy social and economic impact on all societies and for which there is still no cure. Multitarget-directed ligands (MTDLs) seem to be a promising therapeutic strate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::26ce8010cb21628707a41821b4b908f7

Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy

Autor: Vincent Luzet, José Marco-Contelles, Kamil Musilek, Irene Pachón-Angona, Isabel Iriepa, Hélène Martin, María-Jesús Oset-Gasque, Daniel Diez-Iriepa, Rudolf Andrýs, Ignacio Moraleda, Bernard Refouvelet, Lhassane Ismaili

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 479-489 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname

We describe herein the design, multicomponent synthesis and biological studies of new donepezil + chromone + melatonin hybrids as potential agents for Alzheimer’s disease (AD) therapy. We have identified compound 14n as promising multitarget small

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72641e085d496edc5d8aa40a9f816192
https://doi.org/10.1080/14756366.2018.1545766