Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Bernard P. Schimmer"'
Autor:
Bernard P. Schimmer, Joshua O. Scheys, Jennivine Tsao, Sara Mostafavi, Martha Cordova, Quaid Morris
Publikováno v:
Molecular and Cellular Endocrinology. 336:85-91
The contribution of steroidogenic factor 1 (SF-1) to the gene expression profile of Y1 mouse adrenocortical cells was evaluated using short hairpin RNAs to knockdown SF-1. The reduced level of SF-1 RNA was associated with global changes that affected
Publikováno v:
Endocrinology. 149:3668-3678
The type 4 adenylyl cyclase, Adcy4, is the least abundant of five different adenylyl cyclase isoforms expressed in the Y1 mouse adrenocortical cell line and is deficient in a Y1 mutant with impaired steroidogenic factor 1 (SF1) activity. This study e
Publikováno v:
Molecular and Cellular Endocrinology. :102-107
This report summarizes the genome-wide effects of ACTH on transcript accumulation in mouse adrenal Y1 cells and the relative contributions of the cAMP-, protein kinase C- and Ca(2+)-dependent signaling pathways to these actions of the hormone. ACTH a
Autor:
Bernard P. Schimmer
Publikováno v:
Molecular and cellular endocrinology. 408
Autor:
Quaid Morris, Andrew Tsao, Henry Cheng, Martha Cordova, Aaron D. Schimmer, Bernard P. Schimmer, Andrew B. Goryachev
Publikováno v:
Endocrinology. 147:2357-2367
ACTH regulates the steroidogenic capacity, size, and structural integrity of the adrenal cortex through a series of actions involving changes in gene expression; however, only a limited number of ACTH-regulated genes have been identified, and these o
Publikováno v:
Molecular and Cellular Endocrinology. 215:101-108
Forskolin-resistant mutants of a mouse adrenocortical cell line present a complex phenotype in which adenylyl cyclase (AC) is resistant to activation by forskolin and by ACTH. ACTH-resistance results from a defect affecting transcription of the ACTH
Publikováno v:
Molecular and Cellular Endocrinology. 214:155-165
Four mutant clones independently derived from the Y1 mouse adrenocortical tumor cell line have adenylyl cyclase (AC) activities that are resistant to forskolin, a direct activator of AC. In this study the AC isoform composition of the forskolin-resis
Publikováno v:
Endocrinology. 143:4031-4037
ACTH resistance in mutant derivatives of the Y1 mouse adrenocortical tumor cell line results from a defect that affects the activity of steroidogenic factor-1 (SF1), thereby preventing the expression of the melanocortin-2 receptor. In this report, we
Autor:
Neil A. Hanley, Liping Zhao, Keith L. Parker, Xunrong Luo, Nancy R. Stallings, Douglas A. Rice, Marit Bakke, Deepak S. Lala, Claudia Frigeri, Bernard P. Schimmer, Margaret Wong, Yayoi Ikeda
Publikováno v:
Recent Progress in Hormone Research. 57:19-36
The orphan nuclear receptor steroidogenic factor 1 (SF-1, also called Ad4BP and officially designated NR5A1) has emerged as an essential regulator of endocrine development and function. Initially identified as a tissue-specific transcriptional regula