Zobrazeno 1 - 10
of 870
pro vyhledávání: '"Bernard Moss"'
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-12 (2023)
Abstract SARS-CoV-2 vaccines prevent severe disease but are less efficient in averting infection and transmission of variant strains, making it imperative to explore ways of enhancing protection. Use of inbred mice expressing the human SARS-CoV-2 rec
Externí odkaz:
https://doaj.org/article/4b3a926604564d05a2265b6d73e4fd43
Autor:
Pascal Mutz, Wolfgang Resch, Guilhem Faure, Tatiana G. Senkevich, Eugene V. Koonin, Bernard Moss
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Viruses with large, double-stranded DNA genomes captured the majority of their genes from their hosts at different stages of evolution. The origins of many virus genes are readily detected through significant sequence similarity with cellula
Externí odkaz:
https://doaj.org/article/56e4139bff0a4908b3e223e6f764f537
Autor:
Lalita Priyamvada, Wouter W Kallemeijn, Monica Faronato, Kimberly Wilkins, Cynthia S Goldsmith, Catherine A Cotter, Suany Ojeda, Roberto Solari, Bernard Moss, Edward W Tate, Panayampalli Subbian Satheshkumar
Publikováno v:
PLoS Pathogens, Vol 18, Iss 10, p e1010662 (2022)
We have recently shown that the replication of rhinovirus, poliovirus and foot-and-mouth disease virus requires the co-translational N-myristoylation of viral proteins by human host cell N-myristoyltransferases (NMTs), and is inhibited by treatment w
Externí odkaz:
https://doaj.org/article/1b85968db8404d64b270c818449b4213
Autor:
Ruikang Liu, Jeffrey L. Americo, Patricia L. Earl, Jack Villani, Catherine A. Cotter, Bernard Moss
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Although providing long-lasting immunity, smallpox vaccination was associated with local and systemic reactions and rarely with severe complications, including progressive vaccinia and postvaccinia encephalitis. As the Dryvax smallpox vaccin
Externí odkaz:
https://doaj.org/article/cea8ac3d08024dea8e5622a4976a47fd
Autor:
Bernard Moss, Geoffrey L Smith
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009911 (2021)
Externí odkaz:
https://doaj.org/article/280091c82bd64fc4b4494c8ed23c435a
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT The survival of viruses depends on their ability to resist host defenses and, of all animal virus families, the poxviruses have the most antidefense genes. Orthopoxviruses (ORPV), a genus within the subfamily Chordopoxvirinae, infect diverse
Externí odkaz:
https://doaj.org/article/6524c4c3f3dd45dea764d78e81976b50
Autor:
Andrew T. Jones, Xiaoying Shen, Korey L. Walter, Celia C. LaBranche, Linda S. Wyatt, Georgia D. Tomaras, David C. Montefiori, Bernard Moss, Dan H. Barouch, John D. Clements, Pamela A. Kozlowski, Raghavan Varadarajan, Rama Rao Amara
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Oral vaccination is a potential option to elicit systemic and mucosal immunity against HIV. Here, Jones et al. show that oral vaccination with a modified needle-free injector induces protective immunity against SHIV in non-human primates and is super
Externí odkaz:
https://doaj.org/article/3261e8231c1a42bea898a73162efaeea
Autor:
Chen Peng, Linda S Wyatt, Shira G Glushakow-Smith, Madhu Lal-Nag, Andrea S Weisberg, Bernard Moss
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008845 (2020)
Modified vaccinia virus Ankara (MVA) is an approved smallpox vaccine and a promising vaccine vector for other pathogens as well as for cancer therapeutics with more than 200 current or completed clinical trials. MVA was derived by passaging the paren
Externí odkaz:
https://doaj.org/article/2758ad6b1989446980b5bfd2586a1fa2
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008505 (2020)
The wild-derived inbred CAST/EiJ mouse, one of eight founder strains in the Collaborative Cross panel, is an exceptional model for studying monkeypox virus (MPXV), an emerging human pathogen, and other orthopoxviruses including vaccinia virus (VACV).
Externí odkaz:
https://doaj.org/article/4108e96b1d874f0f902fc222e90d287d
Publikováno v:
Cell Reports, Vol 29, Iss 4, Pp 816-828.e6 (2019)
Summary: IFITs are interferon-induced proteins that can bind 5′-triphosphate or ribose-unmethylated capped ends of mRNA to inhibit translation. Although some viruses avoid IFITs by synthesizing RNAs with eukaryotic-like caps, no viral proteins were
Externí odkaz:
https://doaj.org/article/4ce6ad4df97a4dbebe8b3a2df7bd76b7