Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Bernard Maillère"'
Autor:
Cyril Planchais, Ignacio Fernández, Benjamin Chalopin, Timothée Bruel, Pierre Rosenbaum, Maxime Beretta, Jordan D. Dimitrov, Laurine Conquet, Flora Donati, Matthieu Prot, Françoise Porrot, Delphine Planas, Isabelle Staropoli, Florence Guivel-Benhassine, Eduard Baquero, Sylvie van der Werf, Ahmed Haouz, Etienne Simon-Lorière, Xavier Montagutelli, Bernard Maillère, Félix A. Rey, Pablo Guardado-Calvo, Hervé Nozach, Olivier Schwartz, Hugo Mouquet
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110354- (2024)
Summary: Antibodies play a pivotal role in protecting from SARS-CoV-2 infection, but their efficacy is challenged by the continuous emergence of viral variants. In this study, we describe two broadly neutralizing antibodies cloned from the memory B c
Externí odkaz:
https://doaj.org/article/c653ff8957ad4f029dc47c33231f0107
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Non-mutated FVIII-specific CD4 T cell epitopes have been recently found to contribute to the development of inhibitors in patients with hemophilia A (HA), while auto-reactive CD4 T cells specific to FVIII circulate in the blood of healthy individuals
Externí odkaz:
https://doaj.org/article/73797c65c3b543d0848c1d94104098aa
Autor:
Ana Antunes, Luis Alvarez-Vallina, Federico Bertoglio, Nicolas Bouquin, Stéphanie Cornen, Francis Duffieux, Pierre Ferré, Raphaëlle Gillet, Christian Jorgensen, Mark B Leick, Bernard Maillère, Hélène Negre, Mireia Pelegrin, Nicolas Poirier, Dietmar Reusch, Bruno Robert, Guy Serre, Alain Vicari, Martin Villalba, Christoph Volpers, Gavin Vuddamalay, Hervé Watier, Thierry Wurch, Lennart Zabeau, Stefan Zielonka, Baolin Zhang, Alain Beck, Pierre Martineau
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTThe annual “Antibody Industrial Symposium”, co-organized by LabEx MAbImprove and MabDesign, held its 10th anniversary edition in Montpellier, France, on June 28–29, 2022. The meeting focused on new results and concepts in antibody engin
Externí odkaz:
https://doaj.org/article/31023432ae874425aa6af8d355c0d7fb
Autor:
Tiphanie Pruvost, Magali Mathieu, Steven Dubois, Bernard Maillère, Emmanuelle Vigne, Hervé Nozach
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTDelineating the precise regions on an antigen that are targeted by antibodies has become a key step for the development of antibody therapeutics. X-ray crystallography and cryogenic electron microscopy are considered the gold standard for pro
Externí odkaz:
https://doaj.org/article/4617046681ba4c809885e2d178d0a302
Autor:
Coline Sivelle, Raphael Sierocki, Youen Lesparre, Aurore Lomet, Wagner Quintilio, Steven Dubois, Evelyne Correia, Ana Maria Moro, Bernard Maillère, Hervé Nozach
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Removal of CD4 T cell epitopes from therapeutic antibody sequences is expected to mitigate their potential immunogenicity, but its application is complicated by the location of their T cell epitopes, which mainly overlap with complementarity-determin
Externí odkaz:
https://doaj.org/article/661bf0eac1704f79876b3f14f8137612
Autor:
Adrien Laroche, Maria Lucia Orsini Delgado, Benjamin Chalopin, Philippe Cuniasse, Steven Dubois, Raphaël Sierocki, Fabrice Gallais, Stéphanie Debroas, Laurent Bellanger, Stéphanie Simon, Bernard Maillère, Hervé Nozach
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Here, we report the molecular engineering of nanobodies that bind with picomolar affinity to both SARS-CoV-1 and SARS-CoV-2 receptor-binding domains (RBD) and are highly neutralizing. We applied deep mutational engineering to VHH72, a nanobody initia
Externí odkaz:
https://doaj.org/article/3da20fd9f9324650a662337d19b7bcbc
Autor:
Marie de Bourayne, Sylvain Meunier, Samuel Bitoun, Evelyne Correia, Xavier Mariette, Hervé Nozach, Bernard Maillère
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Pegylation of biopharmaceuticals is the most common strategy to increase their half-life in the blood and is associated with a reduced immunogenicity. As antigen presentation is a primary event in the activation of CD4 T-cells and initiation of Anti-
Externí odkaz:
https://doaj.org/article/1691747e1b1a4fa5b04d3fbcc5117f00
Autor:
Aurélien Azam, Sergio Mallart, Stephane Illiano, Olivier Duclos, Catherine Prades, Bernard Maillère
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Non-natural modifications are widely introduced into peptides to improve their therapeutic efficacy, but their impact on immunogenicity remains largely unknown. As the CD4 T-cell response is a key factor in triggering immunogenicity, we investigated
Externí odkaz:
https://doaj.org/article/d2f39cf4adb140618c7d6778feb5447c
Autor:
Raphaël Sierocki, Bakhos Jneid, Maria Lucia Orsini Delgado, Marc Plaisance, Bernard Maillère, Hervé Nozach, Stéphanie Simon
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009231 (2021)
Salmonella and Shigella bacteria are food- and waterborne pathogens that are responsible for enteric infections in humans and are still the major cause of morbidity and mortality in the emerging countries. The existence of multiple Salmonella and Shi
Externí odkaz:
https://doaj.org/article/f3eee3cf2fda4c20a74d33ff1f0da27d
Autor:
Sabrina Pollastro, Marie de Bourayne, Giulia Balzaretti, Aldo Jongejan, Barbera D. C. van Schaik, Ilse T. G. Niewold, Antoine H. C. van Kampen, Bernard Maillère, Niek de Vries
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
High-throughput T-cell receptor repertoire sequencing constitutes a powerful tool to study T cell responses at the clonal level. However, it does not give information on the functional phenotype of the responding clones and lacks a statistical framew
Externí odkaz:
https://doaj.org/article/a544f06d19f944f1a73b442aee6b2615