Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Bernard Lagan"'
Autor:
Erwan Atcheson, Bernard Lagan, Ross McCormick, Hilary Edgar, Robert E. B. Hanna, Naomi H. Rutherford, Amanda McEvoy, Kathryn M. Huson, Alan Gordon, Aurelie Aubry, Mary Vickers, Mark W. Robinson, Jason P. Barley
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
The incidence of paramphistomosis, caused by the rumen fluke, Calicophoron daubneyi, has greatly increased within Europe in the last 15–20 years. However, the production impacts of this disease are poorly understood. This study firstly aimed to inv
Externí odkaz:
https://doaj.org/article/672fbbefc9a14dc0baf57a17b11173a0
Autor:
Fanny Momboisse, Giacomo Nardi, Philippe Colin, Melanie Hery, Nelia Cordeiro, Simon Blachier, Olivier Schwartz, Fernando Arenzana-Seisdedos, Nathalie Sauvonnet, Jean-Christophe Olivo-Marin, Bernard Lagane, Thibault Lagache, Anne Brelot
Publikováno v:
eLife, Vol 11 (2022)
G-protein-coupled receptors (GPCR) are present at the cell surface in different conformational and oligomeric states. However, how these states impact GPCRs biological function and therapeutic targeting remains incompletely known. Here, we investigat
Externí odkaz:
https://doaj.org/article/6ee4f1070d8b415380bac80983845833
Autor:
Mingyu Han, Vincent Cantaloube-Ferrieu, Maorong Xie, Marie Armani-Tourret, Marie Woottum, Jean-Christophe Pagès, Philippe Colin, Bernard Lagane, Serge Benichou
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010335 (2022)
Macrophages (MΦ) are increasingly recognized as HIV-1 target cells involved in the pathogenesis and persistence of infection. Paradoxically, in vitro infection assays suggest that virus isolates are mostly T-cell-tropic and rarely MΦ-tropic. The la
Externí odkaz:
https://doaj.org/article/ef7584e2dffe4fb68a33c167a4c71868
Autor:
Zhicheng Zhou, Isabelle Staropoli, Anne Brelot, Peggy Suzanne, Aurélien Lesnard, Fanny Fontaine, Serge Perato, Sylvain Rault, Olivier Helynck, Fernando Arenzana-Seisdedos, Jana Sopkova-de Oliveira Santos, Bernard Lagane, Hélène Munier-Lehmann, Philippe Colin
Publikováno v:
Molecules, Vol 28, Iss 3, p 1156 (2023)
The chemokine receptor CXCR4 and its ligand CXCL12 regulate leukocyte trafficking, homeostasis and functions and are potential therapeutic targets in many diseases such as HIV-1 infection and cancers. Here, we identified new CXCR4 ligands in the CERM
Externí odkaz:
https://doaj.org/article/2649592c172747d6a3a95d1a2c3b0285
Autor:
Marie Armani-Tourret, Zhicheng Zhou, Romain Gasser, Isabelle Staropoli, Vincent Cantaloube-Ferrieu, Yann Benureau, Javier Garcia-Perez, Mayte Pérez-Olmeda, Valérie Lorin, Bénédicte Puissant-Lubrano, Lambert Assoumou, Constance Delaugerre, Jean-Daniel Lelièvre, Yves Lévy, Hugo Mouquet, Guillaume Martin-Blondel, Jose Alcami, Fernando Arenzana-Seisdedos, Jacques Izopet, Philippe Colin, Bernard Lagane
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009526 (2021)
HIV-1 infects CD4 T lymphocytes (CD4TL) through binding the chemokine receptors CCR5 or CXCR4. CXCR4-using viruses are considered more pathogenic, linked to accelerated depletion of CD4TL and progression to AIDS. However, counterexamples to this para
Externí odkaz:
https://doaj.org/article/f6a51f49aafc435696f3d3a1a1dc8d6f
Publikováno v:
Viruses, Vol 13, Iss 7, p 1395 (2021)
The chemokine receptor CCR5 is a key player in HIV-1 infection. The cryo-EM 3D structure of HIV-1 envelope glycoprotein (Env) subunit gp120 in complex with CD4 and CCR5 has provided important structural insights into HIV-1/host cell interaction, yet
Externí odkaz:
https://doaj.org/article/a532e9e90abe4ea8b881c4da1fe41bc0
Autor:
Shanti Souriant, Luciana Balboa, Maeva Dupont, Karine Pingris, Denise Kviatcovsky, Céline Cougoule, Claire Lastrucci, Aicha Bah, Romain Gasser, Renaud Poincloux, Brigitte Raynaud-Messina, Talal Al Saati, Sandra Inwentarz, Susana Poggi, Eduardo Jose Moraña, Pablo González-Montaner, Marcelo Corti, Bernard Lagane, Isabelle Vergne, Carolina Allers, Deepak Kaushal, Marcelo J. Kuroda, Maria del Carmen Sasiain, Olivier Neyrolles, Isabelle Maridonneau-Parini, Geanncarlo Lugo-Villarino, Christel Vérollet
Publikováno v:
Cell Reports, Vol 26, Iss 13, Pp 3586-3599.e7 (2019)
Summary: The tuberculosis (TB) bacillus, Mycobacterium tuberculosis (Mtb), and HIV-1 act synergistically; however, the mechanisms by which Mtb exacerbates HIV-1 pathogenesis are not well known. Using in vitro and ex vivo cell culture systems, we show
Externí odkaz:
https://doaj.org/article/dfbdfc33ba9f4d8eaeeb0d3758df1e7e
Autor:
Philippe Colin, Zhicheng Zhou, Isabelle Staropoli, Javier Garcia-Perez, Romain Gasser, Marie Armani-Tourret, Yann Benureau, Nuria Gonzalez, Jun Jin, Bridgette J Connell, Stéphanie Raymond, Pierre Delobel, Jacques Izopet, Hugues Lortat-Jacob, Jose Alcami, Fernando Arenzana-Seisdedos, Anne Brelot, Bernard Lagane
Publikováno v:
PLoS Pathogens, Vol 14, Iss 12, p e1007432 (2018)
CCR5 plays immune functions and is the coreceptor for R5 HIV-1 strains. It exists in diverse conformations and oligomerization states. We interrogated the significance of the CCR5 structural diversity on HIV-1 infection. We show that envelope glycopr
Externí odkaz:
https://doaj.org/article/04c4b9e73bd8406d87eb80a540994e50
Autor:
Patricia Rueda, Karl Balabanian, Bernard Lagane, Isabelle Staropoli, Ken Chow, Angelique Levoye, Cedric Laguri, Rabia Sadir, Thierry Delaunay, Elena Izquierdo, Jose Luis Pablos, Elena Lendinez, Antonio Caruz, Diego Franco, Françoise Baleux, Hugues Lortat-Jacob, Fernando Arenzana-Seisdedos
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2543 (2008)
The CXCL12gamma chemokine arises by alternative splicing from Cxcl12, an essential gene during development. This protein binds CXCR4 and displays an exceptional degree of conservation (99%) in mammals. CXCL12gamma is formed by a protein core shared b
Externí odkaz:
https://doaj.org/article/575c6fb3e913424fa7902048a0b736fb