Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Bernard L. Flynn"'
Autor:
Ruth R. Magaye, Feby Savira, Xin Xiong, Kevin Huynh, Peter J. Meikle, Christopher Reid, Bernard L. Flynn, David Kaye, Danny Liew, Bing H. Wang
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 35, Iss , Pp 100837- (2021)
The sphingolipid de novo synthesis pathway, encompassing the sphingolipids, the enzymes and the cell membrane receptors, are being investigated for their role in diseases and as potential therapeutic targets. The intermediate sphingolipids such as di
Externí odkaz:
https://doaj.org/article/c45cfbceff2b4806a0ec381c0bc07df0
Autor:
Shuqi Chen, Daniel L. Priebbenow, Julie Somkhit, Carmen V. Scullino, Keli Agama, Yves Pommier, Bernard L. Flynn
Publikováno v:
Chemistry – A European Journal. 28
Publikováno v:
Organic Letters. 23:7055-7058
Directed ortho-lithiation (DoL) has been developed as an effective method for the ortho-substitution of BINOL-phosphoric acid and BINOL-N-triflylphosphoramide (BINOL-P-acids). It can be employed in the rapid assembly of either mono- or disubstituted
Autor:
Bernard L. Flynn, Annaliese S. Dillon
Publikováno v:
Organic Letters. 22:2987-2990
Polyfused chalcogenophenes are prepared in one step through polyelectrophilic cyclization of polyynes using the ambiphilic reagent MeACl (A = S, Se, or Te). Up to four new rings have been generated under mild conditions, including thiophenes, selenop
Publikováno v:
Organic letters. 23(18)
Directed
Autor:
Bernard L. Flynn, Ruth R Magaye, Xin Xiong, Peter J Meikle, Danny Liew, Feby Savira, Kevin Huynh, David M. Kaye, Bing Hui Wang, Christopher M. Reid
Publikováno v:
International Journal of Cardiology. Heart & Vasculature
International Journal of Cardiology: Heart & Vasculature, Vol 35, Iss, Pp 100837-(2021)
International Journal of Cardiology: Heart & Vasculature, Vol 35, Iss, Pp 100837-(2021)
Graphical abstract
Highlights • Increasing sphingolipid metabolism in cardiac fibroblasts inhibited TGFβ mediated collagen synthesis. • Dihydrosphingosine inhibits collagen synthesis in cardiac fibroblasts through substrate-enzyme-receptor
Highlights • Increasing sphingolipid metabolism in cardiac fibroblasts inhibited TGFβ mediated collagen synthesis. • Dihydrosphingosine inhibits collagen synthesis in cardiac fibroblasts through substrate-enzyme-receptor
Autor:
Dovile Anderson, David M. Kaye, Bernard L. Flynn, Danny Liew, Bing Hui Wang, Carmen V. Scullino, Ruth R Magaye, Darren J. Creek, Christopher M. Reid, Yue Hua, Andrew R Kompa, Li Huang, Xin Xiong, Stuart M. Pitson, Feby Savira
Non-dialysable protein-bound uremic toxins (PBUTs) contribute to the development of cardiovascular disease (CVD) in chronic kidney disease (CKD) and vice versa. PBUTs have been shown to alter sphingolipid imbalance. Dihydroceramide desaturase 1 (Des1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2841aa34de246c4a3de7fdcc183096f
https://hdl.handle.net/11541.2/148203
https://hdl.handle.net/11541.2/148203
Autor:
Li Huang, David M. Kaye, Bing Hui Wang, Feby Savira, Christopher M. Reid, Bernard L. Flynn, Danny Liew, Ruth R Magaye, Xin Xiong, Yue Hua
Publikováno v:
The international journal of biochemistrycell biology. 134
Cardiac fibrosis and myocyte hypertrophy play contributory roles in the progression of diseases such as heart Failure (HF) through what is collectively termed cardiac remodelling. The phosphoinositide 3- kinase (PI3K), protein kinase B (Akt) and mamm
Publikováno v:
Circulation Research. 127
Background: Cardiac fibrosis is one of the hallmarks of cardiac remodelling in cardiomyopathies such as heart Failure (HF). Dyslipidemia plays a role in the progression of HF. The sphingolipid, dihydrosphingosine 1 phosphate (dhS1P) has been shown to
Autor:
Carmen V. Scullino, Stuart M. Pitson, Andrew R Kompa, Christopher A. Reid, David M. Kaye, Bing Hui Wang, Bernard L. Flynn, Feby Savira, Danny Liew, Darren J. Kelly, Li Huang, Xin Xiong, Ruth Magaye
Publikováno v:
Vascular pharmacology. 141
Protein-bound uremic toxins (PBUTs) have adverse effects on vascular function, which is imperative in the progression of cardiovascular and renal diseases. The role of sphingolipids in PBUT-mediated vasculo-endothelial pathophysiology is unclear. Thi