Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Bernard L, Schneider"'
Autor:
Sofia Spataro, Bohumil Maco, Stéphane Escrig, Louise Jensen, Lubos Polerecky, Graham Knott, Anders Meibom, Bernard L. Schneider
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract In Parkinson’s disease, pathogenic factors such as the intraneuronal accumulation of the protein α-synuclein affect key metabolic processes. New approaches are required to understand how metabolic dysregulations cause degeneration of vuln
Externí odkaz:
https://doaj.org/article/4df05915fb974e5a96d48ef8028a1f10
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract There is no FDA-approved medication for methamphetamine (METH) use disorder. New therapeutic approaches are needed, especially for people who use METH heavily and are at high risk for overdose. This study used genetically engineered rats to
Externí odkaz:
https://doaj.org/article/9302f1ad7bc14003b161e62e8c9e15ca
Autor:
Daniel Blessing, Gabriel Vachey, Catherine Pythoud, Maria Rey, Vivianne Padrun, Florian M. Wurm, Bernard L. Schneider, Nicole Déglon
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 14-26 (2019)
Adeno-associated virus (AAV) vectors are currently among the most commonly applied for in vivo gene therapy approaches. The evaluation of vectors during clinical development requires the production of considerable amounts of highly pure and potent ve
Externí odkaz:
https://doaj.org/article/c64df449fff64ecabe0fef84dace7fbe
Autor:
Marianna M. Koga, Adrien Engel, Matteo Pigni, Christine Lavanchy, Mathias Stevanin, Vanessa Laversenne, Bernard L. Schneider, Hans Acha-Orbea
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Dendritic cells (DCs) are professional antigen-presenting cells involved in the initiation of immune responses. We generated a tolerogenic DC (tolDC) line that constitutively secretes interleukin-10 (IL10-DCs), expressed lower levels of co-stimulator
Externí odkaz:
https://doaj.org/article/d11a3baee5d141f88c254681665e7d20
Autor:
Marc-Olivier Deguise, Chantal Pileggi, Yves De Repentigny, Ariane Beauvais, Alexandra Tierney, Lucia Chehade, Jean Michaud, Maica Llavero-Hurtado, Douglas Lamont, Abdelmadjid Atrih, Thomas M. Wishart, Thomas H. Gillingwater, Bernard L. Schneider, Mary-Ellen Harper, Simon H. Parson, Rashmi Kothary
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 354-377.e3 (2021)
Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is considered a health epidemic with potential devastating effects on the patients and the healthcare systems. Current preclinical models of NAFLD are invariably imperfect and generally take
Externí odkaz:
https://doaj.org/article/17bff1dec6fd49edbbb066b4aa9e5172
Autor:
Guillaume Petit-Pierre, Philippe Colin, Estelle Laurer, Julien Déglon, Arnaud Bertsch, Aurélien Thomas, Bernard L. Schneider, Philippe Renaud
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Current approaches studying the collection of extracellular fluid to monitor neurological disorders have temporal resolution limitations. Here the authors show functional in vivo validation of a droplet collection system included at the tip of a neur
Externí odkaz:
https://doaj.org/article/7f7ab5e81b364384be8b244ce665d823
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-19 (2017)
Abstract Background Metabolic perturbations and slower renewal of cellular components associated with aging increase the risk of Parkinson’s disease (PD). Declining activity of AMPK, a critical cellular energy sensor, may therefore contribute to ne
Externí odkaz:
https://doaj.org/article/701c2634887a482ba26dc2d0ce8ba343
Autor:
Gabriela Martínez, René L. Vidal, Pablo Mardones, Felipe G. Serrano, Alvaro O. Ardiles, Craig Wirth, Pamela Valdés, Peter Thielen, Bernard L. Schneider, Bredford Kerr, Jose L. Valdés, Adrian G. Palacios, Nibaldo C. Inestrosa, Laurie H. Glimcher, Claudio Hetz
Publikováno v:
Cell Reports, Vol 14, Iss 6, Pp 1382-1394 (2016)
Contextual memory formation relies on the induction of new genes in the hippocampus. A polymorphism in the promoter of the transcription factor XBP1 was identified as a risk factor for Alzheimer’s disease and bipolar disorders. XBP1 is a major regu
Externí odkaz:
https://doaj.org/article/4539dd020bff430c83c22fa2d24022bb
Autor:
Cylia Rochat, Nathalie Bernard‐Marissal, Emma Källstig, Sylvain Pradervand, Florence E. Perrin, Patrick Aebischer, Cédric Raoul, Bernard L. Schneider
Publikováno v:
Glia
Glia, Wiley, 2022, ⟨10.1002/glia.24140⟩
Glia, 2022, ⟨10.1002/glia.24140⟩
Glia, Wiley, 2022, ⟨10.1002/glia.24140⟩
Glia, 2022, ⟨10.1002/glia.24140⟩
In amyotrophic lateral sclerosis (ALS) caused by SOD1 gene mutations, both cell-autonomous and noncell-autonomous mechanisms lead to the selective degeneration of motoneurons (MN). Here, we evaluate the therapeutic potential of gene therapy targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e1f9283d784fb6dcafc113711daf4f
https://doi.org/10.1002/glia.24140
https://doi.org/10.1002/glia.24140
Autor:
Elpida Tsika, An Phu Tran Nguyen, Julien Dusonchet, Philippe Colin, Bernard L. Schneider, Darren J. Moore
Publikováno v:
Neurobiology of Disease, Vol 77, Iss , Pp 49-61 (2015)
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant Parkinson's disease (PD). LRRK2 contains functional GTPase and kinase domains. The most common G2019S mutation enhances the kinase activity of LRRK2 in vi
Externí odkaz:
https://doaj.org/article/5f6f2edbaa834831946d4e0b34694c2d