Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Bernard Juskowiak"'
Publikováno v:
Sensors, Vol 22, Iss 2, p 500 (2022)
In this work we investigated the effect of a DNA oligonucleotide sequence on the activity of a DNAzyme with covalently attached hemin. For this purpose, we synthesized seven DNA-hemin conjugates. All DNA-hemin conjugates as well as DNA/hemin complexe
Externí odkaz:
https://doaj.org/article/31e4dd106fde4b1b9ad5f3170745176b
Autor:
Joanna Kosman, Bernard Juskowiak
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 7902 (2021)
In this work we examined the properties of thrombin-binding aptamer (TBA) modified by the introduction of inversion of polarity sites (IPS) in order to assess the effect of modification on the activation of TBA to serve as DNAzyme with peroxidase-lik
Externí odkaz:
https://doaj.org/article/15cb6a08b72a431190f09b5e4950cc05
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 8190 (2020)
Here, we report the synthesis of a quantum dot (QD)-DNA covalent conjugate to be used as an H2O2-free DNAzyme system with oxidase activity. Amino-coupling conjugation was carried out between amino-modified oligonucleotides (CatG4-NH2) and carboxylate
Externí odkaz:
https://doaj.org/article/e65741d48f7c4262a9d90ac6e82ce370
Autor:
Patrycja Bielecka, Bernard Juskowiak
Publikováno v:
Molecules, Vol 20, Iss 10, Pp 18511-18525 (2015)
There are cytosine-rich regions in the genome that bind protons with high specificity. Thus protonated C-rich sequence may undergo folding to tetraplex structures called i-motifs. Therefore, one can regard such specific C-rich oligonucleotides as apt
Externí odkaz:
https://doaj.org/article/652c726f56e14630bcd012cdd7684ca4
Publikováno v:
Chemosensors, Vol 3, Iss 3, Pp 211-223 (2015)
Cytosine-rich nucleic acids undergo pH-stimulated structural transitions leading to formation of an i-motif architecture at an acidic pH. Thus, i-motifs are good foundation for designing simple pH-sensitive fluorescent probes. We report here steady-s
Externí odkaz:
https://doaj.org/article/b0a0141cc22241b092acce7c305c18cc
Publikováno v:
Chemosensors, Vol 2, Iss 4, Pp 267-286 (2014)
In this study we report on the spectral properties and G-quadruplex folding ability of fluorescent oligonucleotide probes modified by the attachment of a cholesterol moiety. These probes were designed and studied in order to verify their potential as
Externí odkaz:
https://doaj.org/article/7e2a2bf76bb644e9ba9f7f05aad310cd
Autor:
Agata Głuszyńska, Bernard Juskowiak
Publikováno v:
Molecules, Vol 24, Iss 5, p 965 (2019)
Microwave formylation of carbazole derivatives was investigated and 3-monoaldehydes were obtained in high yield. A potential DNA-binding ligand, 3-[(3-ethyl)-2-vinylbenzothiazolium]-9-N-ethyl carbazole iodide, was synthesized and characterized includ
Externí odkaz:
https://doaj.org/article/2dd1213daa634e649db30ed61b0ba82f
Publikováno v:
Molecules, Vol 24, Iss 5, p 952 (2019)
The i-motif is a four-stranded DNA structure formed from the cytosine (C)-rich ssDNA sequence, which is stabilized in slightly acidic pH. Additionally, labeling of a cytosine-rich sequence with a fluorescent molecule may constitute a way to construct
Externí odkaz:
https://doaj.org/article/fdaaa4eaeb4c4009b411e38a612f8986
Publikováno v:
Molecules, Vol 23, Iss 12, p 3154 (2018)
The carbazole ligand 3 was synthesized, characterized and its binding interactions with human telomeric (22HT) G-quadruplex DNA in Na+ and K+-containing buffer were investigated by ultraviolet-visible (UV-Vis) spectrophotometry, fluorescence, circula
Externí odkaz:
https://doaj.org/article/3709e59fc4e94a649c987a17e1abb3ad
Publikováno v:
Sensors, Vol 18, Iss 7, p 2201 (2018)
The purpose of the present work was to design, synthesize and spectrally characterize cholesterol-anchored fluorescent oligonucleotide probes (Ch(F-TBA-T), Ch(py-TBA-py)), based on G-quadruplexes, which were able to incorporate into a lipid structure
Externí odkaz:
https://doaj.org/article/46c200688af24b91bfd6de60af1bfa9d