Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Bernard J. Moncla"'
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158687 (2016)
In this study, we characterized the glycome of cervical-vaginal fluid, collected with a Catamenial cup. We quantified: glycosidase levels; sialic acid and high mannose specific lectin binding; mucins, MUC1, MUC4, MUC5AC, MUC7; and albumin in the samp
Externí odkaz:
https://doaj.org/article/70414cede4944fc38a1864130eddb59d
Autor:
Bernard J Moncla, Catherine A Chappell, Lara K Mahal, Brian M Debo, Leslie A Meyn, Sharon L Hillier
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127091 (2015)
The objective of this study was to evaluate the impact of hormonal status and bacterial vaginosis (BV) on the glycosidases present and glycosylation changes as assessed by lectin binding to cervicovaginal lavage constituents. Frozen cervicovaginal la
Externí odkaz:
https://doaj.org/article/3b915f33aae840de9c5fdfd5a98dc10f
Autor:
Linlin Wang, Sujeethraj Koppolu, Catherine Chappell, Bernard J Moncla, Sharon L Hillier, Lara K Mahal
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127021 (2015)
The cervicovaginal fluid (CVF) coating the vaginal epithelium is an important immunological mediator, providing a barrier to infection. Glycosylation of CVF proteins, such as mucins, IgG and S-IgA, plays a critical role in their immunological functio
Externí odkaz:
https://doaj.org/article/38c6fac079b44fcd9be2d2c9ff0cc96e
Autor:
Amanda B. Lasnik, Joshua L Fuqua, Lindsay F. Kramzer, Lisa C. Rohan, Nobuyuki Matoba, Krystal Teasley Hamorsky, Bernard J. Moncla, Kenneth E. Palmer, Junmei Zhang, Phillip W. Graebing, Lin Wang
Publikováno v:
AAPS PharmSciTech
Griffithsin (GRFT) has shown potent anti-HIV activity, and it is being developed as a drug candidate for HIV prevention. Successful implementation requires thorough understanding of its preformulation characterization. In this work, preformulation as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d024abb35a2306172bf642cb8cbafee
https://pubmed.ncbi.nlm.nih.gov/33625602
https://pubmed.ncbi.nlm.nih.gov/33625602
Autor:
Charlene S. Dezzutti, Sharon L. Hillier, Lisa C. Rohan, Katherine E. Bunge, Sujeethraj Koppolu, Bernard J. Moncla, Leslie A. Meyn, Ayushi Mathur, Linlin Wang, Lara K. Mahal, Jayeshwar A. Nigam, Charles E. Isaacs
Publikováno v:
ACS Infectious Diseases. 4:1613-1622
Glycosylated proteins (i.e., mucins, IgG) are important mediators of innate antiviral immunity in the vagina; however, our current knowledge of the role that glycan themselves play in genital immunity is relatively low. Herein, we evaluate the relati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8ad654cd1fb4ecc22f179ca0b6b16f
https://doi.org/10.1021/acsinfecdis.8b00157
https://doi.org/10.1021/acsinfecdis.8b00157
Autor:
Lisa C Rohan, Bernard J Moncla, Ratiya Pamela Kunjara Na Ayudhya, Marilyn Cost, Yunda Huang, Fang Gai, Nicole Billitto, J D Lynam, Kara Pryke, Phillip Graebing, Nicole Hopkins, James F Rooney, David Friend, Charlene S Dezzutti
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9310 (2010)
Tenofovir gel has entered into clinical trials for use as a topical microbicide to prevent HIV-1 infection but has no published data regarding pre-clinical testing using in vitro and ex vivo models. To validate our findings with on-going clinical tri
Externí odkaz:
https://doaj.org/article/50f202cf80554ce48f7cec9fec903b9e
Autor:
Nicola Richardson-Harman, Craig W. Hendrix, Hans M. L. Spiegel, Katherine E. Bunge, Mark A. Marzinke, Charlene S. Dezzutti, Leslie A. Meyn, Lisa C. Rohan, Sharon L. Hillier, Brid Devlin, Bernard J. Moncla
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 71:498-505
Background Films may deliver antiretroviral drugs efficiently to mucosal tissues. In this first in-human trial of a vaginal film for delivering the nonnucleoside reverse transcriptase inhibitor dapivirine, safety, pharmacokinetics, and pharmacodynami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a454990852fef2fd23d03e8f5afaf741
https://doi.org/10.1097/qai.0000000000000897
https://doi.org/10.1097/qai.0000000000000897
Autor:
Craig W. Hendrix, Katherine E. Bunge, Charlene S. Dezzutti, Lisa C. Rohan, Hans M. L. Spiegel, Bernard J. Moncla, Nicola Richardson-Harman, Sharon L. Hillier, Jill L. Schwartz, Leslie A. Meyn, Mark A. Marzinke
Publikováno v:
Journal of the International AIDS Society
Introduction Fast‐dissolving vaginal film formulations release antiretroviral drugs directly into vaginal fluid and may be as efficient at drug delivery yet more acceptable to women than gels. In this Phase 1 vaginal film study, the safety, accepta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9780ac5c4529dff9990c88ed69772d
https://pubmed.ncbi.nlm.nih.gov/30101439
https://pubmed.ncbi.nlm.nih.gov/30101439
Autor:
Minlu Hu, Charlene S. Dezzutti, Michael A. Parniak, Stefan G. Sarafianos, Lisa C. Rohan, Bernard J. Moncla, Wei Zhang, Yuan Shi, Tiantian Gong
Publikováno v:
Pharmaceutical Research. 32:2960-2972
EFdA is a potent nucleoside reverse transcriptase inhibitor (NRTI) with activity against a wide spectrum of wild-type and drug resistant HIV-1 variants. CSIC is a tight-binding non-nucleoside reverse transcriptase inhibitor (NNRTI) with demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0fab57f62aa9e7e4bc6020594b889c
https://doi.org/10.1007/s11095-015-1678-2
https://doi.org/10.1007/s11095-015-1678-2
Autor:
Phalguni Gupta, Tiantian Gong, Michael A. Parniak, Bernard J. Moncla, Wei Zhang, Phillip W. Graebing, Lisa C. Rohan, Kerry M. Empey
Publikováno v:
Journal of pharmaceutical innovation. 12(2)
5-Chloro-3-[phenylsulfonyl] indole-2-carboxamide (CSIC) is a highly potent non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 which has been shown to have a more desirable resistance profile than other NNRTIs in the development as HIV pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a1969d36f60ea331aee5b08620d759
https://pubmed.ncbi.nlm.nih.gov/28983328
https://pubmed.ncbi.nlm.nih.gov/28983328