Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Bernard Hoflack"'
Publikováno v:
iScience, Vol 6, Iss , Pp 199-211 (2018)
Summary: Bone-resorbing osteoclasts play a central role in bone remodeling and its pathology. To digest bone, osteoclasts re-organize both F-actin, to assemble podosomes/sealing zones, and membrane traffic, to form bone-facing ruffled borders enriche
Externí odkaz:
https://doaj.org/article/7c4230d63c964233a8729fadeb3fa310
Autor:
Mihaela Anitei, Christoph Stange, Cornelia Czupalla, Christian Niehage, Kai Schuhmann, Pia Sala, Aleksander Czogalla, Theresia Pursche, Ünal Coskun, Andrej Shevchenko, Bernard Hoflack
Publikováno v:
Cell Reports, Vol 20, Iss 9, Pp 2087-2099 (2017)
Clathrin/adaptor protein-1-coated carriers connect the secretory and the endocytic pathways. Carrier biogenesis relies on distinct protein networks changing membrane shape at the trans-Golgi network, each regulating coat assembly, F-actin-based mecha
Externí odkaz:
https://doaj.org/article/50c6132e8a98434ebb14f8a0d239e076
Autor:
María-Victoria Hinckelmann, Amandine Virlogeux, Christian Niehage, Christel Poujol, Daniel Choquet, Bernard Hoflack, Diana Zala, Frédéric Saudou
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
How neurons produce energy to fuel fast axonal transport is only partially understood. Authors here report that most glycolytic enzymes are enriched in motile vesicles, and such glycolytic machinery can produce ATP autonomously to propel vesicle move
Externí odkaz:
https://doaj.org/article/f0cf3b40a24c4fd88c6947f5f247fbd6
Autor:
Martin Sztacho, Sandra Segeletz, Maria Arantzazu Sanchez-Fernandez, Cornelia Czupalla, Christian Niehage, Bernard Hoflack
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164829 (2016)
Bone resorption in vertebrates relies on the ability of osteoclasts to assemble F-actin-rich podosomes that condense into podosomal belts, forming sealing zones. Sealing zones segregate bone-facing ruffled membranes from other membrane domains, and d
Externí odkaz:
https://doaj.org/article/9cffabf101e84fbfb59c6ab64be7815e
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0159824 (2016)
Multipotent mesenchymal stromal cells (MSCs) are promising tools for regenerative medicine. They can be isolated from different sources based on their plastic-adherence property. The identification of reliable cell surface markers thus becomes the Ho
Externí odkaz:
https://doaj.org/article/263637b3a3dd428c87442568f41f04d1
Autor:
Andrea Imle, Libin Abraham, Nikolaos Tsopoulidis, Bernard Hoflack, Kalle Saksela, Oliver T. Fackler
Publikováno v:
mBio, Vol 6, Iss 5 (2015)
ABSTRACT Human immunodeficiency virus type 1 (HIV-1) Nef enhances virus replication and contributes to immune evasion in vivo, but the underlying molecular mechanisms remain incompletely defined. Nef interferes with host cell actin dynamics to restri
Externí odkaz:
https://doaj.org/article/541c697a482f419082ce782f93454599
Autor:
Zita Balklava, Christian Niehage, Heather Currinn, Laura Mellor, Benjamin Guscott, Gino Poulin, Bernard Hoflack, Thomas Wassmer
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130485 (2015)
While the Amyloid Precursor Protein (APP) plays a central role in Alzheimer's disease, its cellular function still remains largely unclear. It was our goal to establish APP function which will provide insights into APP's implication in Alzheimer's di
Externí odkaz:
https://doaj.org/article/37a975215e6641dea43cf0d7be01a434
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103956 (2014)
The Saccharomyces cerevisiae kinase Sat4p has been originally identified as a protein involved in salt tolerance and stabilization of plasma membrane transporters, implicating a cytoplasmic localization. Our study revealed an additional mitochondrial
Externí odkaz:
https://doaj.org/article/001a7cf5a8f7485a9e0ae96efdc45a5a
Autor:
Sofia Traikov, Christoph Stange, Thomas Wassmer, Perrine Paul-Gilloteaux, Jean Salamero, Graça Raposo, Bernard Hoflack
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e109372 (2014)
Septins (SEPTs) form a family of GTP-binding proteins implicated in cytoskeleton and membrane organization, cell division and host/pathogen interactions. The precise function of many family members remains elusive. We show that SEPT6 and SEPT7 comple
Externí odkaz:
https://doaj.org/article/4524cfdce9ab4c52993d2865f5640c3e
Autor:
Maria Arantzazu Sanchez-Fernandez, Silvia Sbacchi, Miguel Correa-Tapia, Ronald Naumann, Jennifer Klemm, Pierre Chambon, Samiya Al-Robaiy, Manfred Blessing, Bernard Hoflack
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37592 (2012)
BACKGROUND: Studies on osteoclasts, the bone resorbing cells, have remained limited due to the lack of transgenic mice allowing the conditional knockout of genes in osteoclasts at any time during development or adulthood. METHODOLOGY/PRINCIPAL FINDIN
Externí odkaz:
https://doaj.org/article/040731520f134468853ec3a7b4f49df1