Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Bernard Gsell"'
Autor:
Daniel Hunziker, Sabrina Reinehr, Marina Palmhof, Natalie Wagner, Thomas Biniasch, Gesa Stute, Patrizio Mattei, Petra Schmitz, Patrick DiGiorgio, Jérôme Hert, Markus G. Rudolph, Joerg Benz, Martine Stihle, Bernard Gsell, Stephan Müller, Rodolfo Gasser, Nina Schonhoven, Christoph Ullmer, Stephanie C. Joachim
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
The autotaxin-lysophosphatidic acid (ATX-LPA) signaling pathway plays a role in a variety of autoimmune diseases, such as rheumatoid arthritis or neurodegeneration. A link to the pathogenesis of glaucoma is suggested by an overactive ATX-LPA axis in
Externí odkaz:
https://doaj.org/article/e94187233b884165a3550015dd83cb98
Autor:
Paola Favuzza, Elena Guffart, Marco Tamborrini, Bianca Scherer, Anita M Dreyer, Arne C Rufer, Johannes Erny, Joerg Hoernschemeyer, Ralf Thoma, Georg Schmid, Bernard Gsell, Araceli Lamelas, Joerg Benz, Catherine Joseph, Hugues Matile, Gerd Pluschke, Markus G Rudolph
Publikováno v:
eLife, Vol 6 (2017)
Invasion of erythrocytes by Plasmodial merozoites is a composite process involving the interplay of several proteins. Among them, the Plasmodium falciparum Cysteine-Rich Protective Antigen (PfCyRPA) is a crucial component of a ternary complex, includ
Externí odkaz:
https://doaj.org/article/020ed0eebb0d43a8aea76fd5a4619c3b
Autor:
Daniel, Hunziker, Sabrina, Reinehr, Marina, Palmhof, Natalie, Wagner, Thomas, Biniasch, Gesa, Stute, Patrizio, Mattei, Petra, Schmitz, Patrick, DiGiorgio, Jérôme, Hert, Markus G, Rudolph, Joerg, Benz, Martine, Stihle, Bernard, Gsell, Stephan, Müller, Rodolfo, Gasser, Nina, Schonhoven, Christoph, Ullmer, Stephanie C, Joachim
Publikováno v:
Frontiers in Pharmacology
The autotaxin-lysophosphatidic acid (ATX-LPA) signaling pathway plays a role in a variety of autoimmune diseases, such as rheumatoid arthritis or neurodegeneration. A link to the pathogenesis of glaucoma is suggested by an overactive ATX-LPA axis in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e106a98c28c71ed353c0f4f28ecfd820
https://pubmed.ncbi.nlm.nih.gov/35126098
https://pubmed.ncbi.nlm.nih.gov/35126098
Autor:
Bernd Kuhn, Franziska Weibel, Rodolfo Gasser, Marco Prunotto, Solange Moll, Martine Stihle, R. Daniel Bonfil, Bernard Gsell, Christian Faul, Remo Hochstrasser, Sabine Uhles, Guy Georges, Ann C. Petersen, Javier Varona Santos, Ricardo Hermosilla, Alexander L. Satz, Hans Richter, Rafael Fridman, Marc Bedoucha, Markus G. Rudolph, Bernd Buettelmann, Anja Harmeier, Martin Ritter, Melanie N. Hug, Alessia Fornoni, Judith Molina-David, Jin Ju Kim, Sylwia Huber, Buelent Kocer, Dominique Burger
Publikováno v:
ACS Chemical Biology
ACS Chemical Biology, Vol. 14, No 1 (2019) pp. 37-49
ACS Chemical Biology, Vol. 14, No 1 (2019) pp. 37-49
The importance of Discoidin Domain Receptor 1 (DDR1) in renal fibrosis has been shown via gene knockout and use of antisense oligonucleotides; however, these techniques act via a reduction of DDR1 protein, while we prove the therapeutic potential of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d66479d1a5d10d891a793eb7b70967
https://doi.org/10.1021/acschembio.8b00866
https://doi.org/10.1021/acschembio.8b00866
Autor:
Araceli Lamelas, Hugues Matile, Anita M Dreyer, Markus G. Rudolph, Joerg Hoernschemeyer, Bernard Gsell, Gerd Pluschke, Paola Favuzza, Johannes Erny, Ralf Thoma, Joerg Benz, Georg Schmid, Arne C. Rufer, Marco Tamborrini, Catherine Joseph, Elena Guffart, Bianca Scherer
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife
Invasion of erythrocytes by Plasmodial merozoites is a composite process involving the interplay of several proteins. Among them, the Plasmodium falciparum Cysteine-Rich Protective Antigen (PfCyRPA) is a crucial component of a ternary complex, includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d89eb67219070cda2fda203743e4f3a2
https://doi.org/10.7554/elife.20383
https://doi.org/10.7554/elife.20383
Autor:
Gerd Pluschke, Paola Favuzza, Ralf Thoma, Araceli Lamelas, Catherine Joseph, Elena Guffart, Bianca Scherer, Anita M Dreyer, Georg Schmid, Joerg Benz, Hugues Matile, Marco Tamborrini, Johannes Erny, Markus G. Rudolph, Joerg Hoernschemeyer, Arne C. Rufer, Bernard Gsell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73d6cef6ac0a8d0b4c5ebbf0a1015138
https://doi.org/10.7554/elife.20383.037
https://doi.org/10.7554/elife.20383.037
Autor:
Robert Ecabert, Yoshiaki Isshiki, Joachim Diez, Beat Spinnler, Guido Hartmann, Jean-Marc Plancher, Wolfgang Haap, François Diederich, David Banner, Nobuo Shimma, Ralf Thoma, Bernd Kuhn, Jörg Benz, Kenji Morikami, Bernard Gsell, Lilli Anselm, Martine Stihle, Leo A. Hardegger
Publikováno v:
ChemMedChem. 6:2048-2054
In two series of small-molecule ligands, one inhibiting human cathepsin L (hcatL) and the other MEK1 kinase, biological affinities were found to strongly increase when an aryl ring of the inhibitors is substituted with the larger halogens Cl, Br, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864d53c96c0d1078765dbd8e5f9d523e
https://doi.org/10.1002/cmdc.201100353
https://doi.org/10.1002/cmdc.201100353
Autor:
Leo A. Hardegger, Wolfgang Haap, Lilli Anselm, Joachim Diez, David Banner, François Diederich, Beat Spinnler, Bernd Kuhn, Jean-Marc Plancher, Bernard Gsell, Guido Hartmann, Jörg Benz, Martine Stihle, Robert Ecabert, Ralf Thoma
Publikováno v:
Angewandte Chemie. 123:329-334
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87178ebd85f70b545bab2b88942b6a69
https://doi.org/10.1002/ange.201006781
https://doi.org/10.1002/ange.201006781
Autor:
Francis Mueller, Martine Stihle, Elodie De Roo, Jörg Benz, Michael Hennig, Ralf Thoma, David Banner, Odile Chomienne, Arne C. Rufer, Bernard Gsell
Publikováno v:
Structure. 14:713-723
SummaryCarnitine palmitoyltransferases 1 and 2 (CPTs) facilitate the import of long-chain fatty acids into mitochondria. Modulation of the catalytic activity of the CPT system is currently under investigation for the development of novel drugs agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bddeda0399bf5241e902e904bbcc3dfb
https://doi.org/10.1016/j.str.2006.01.008
https://doi.org/10.1016/j.str.2006.01.008
Autor:
Walter Huber, Christophe Dhalluin, Doris Brugger, Hans Senn, Bernard Gsell, Alfred Ross, Paul R. Gerber
Publikováno v:
Bioconjugate Chemistry. 16:518-527
Type-I Interferons exert antiviral and antiproliferative activities through the binding to a common cell surface receptor comprising two subunits, IFNAR1 and IFNAR2. Human recombinant Interferon-alpha(2a) (IFNalpha(2a)) is a potent drug (Roferon-A) u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d1f5d54832d2ce9bfe24dcb8729ecc
https://doi.org/10.1021/bc049780h
https://doi.org/10.1021/bc049780h