Výsledky vyhledávání - "Bernard Gagné"

Polymorphisms in the neuronal isoform of tryptophan hydroxylase 2 are associated with bipolar disorder in French Canadian pedigrees

Autor: Bernard Gagné, Nicholas Barden, Mario Harvey, Michel Labbé

Publikováno v: Psychiatric Genetics. 17:17-22

Objective Tryptophan hydroxylase is the rate-limiting enzyme in the serotonin biosynthetic pathway and plays an important role in the regulation of serotonin levels. Recently, a brain-specific isoform, tryptophan hydroxylase 2 or n-tryptophan hydroxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57da8f69c06f047ae6fd18e262a59229
https://doi.org/10.1097/ypg.0b013e3280111877

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P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder

Autor: Daria Salyakina, Manfred Uhr, Elisabeth B. Binder, Marcus Ising, Bertram Müller-Myhsok, Roselind Lieb, Florian Holsboer, Nicholas Barden, Marcelo Paez-Pereda, Susanne Lucae, Michel Labbé, Mario Harvey, Inge Sillaber, Bernard Gagné, Tanja Brückl

Publikováno v: Human Molecular Genetics. 15:2438-2445

The P2RX7 gene is located within a region on chromosome 12q24.31 that has been identified as a susceptibility locus for affective disorders by linkage and association studies. P2RX7 is a purinergic ATP-binding calcium channel expressed in neurons as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f60a8f7103fa8ac6ab20f7688c9893
https://doi.org/10.1093/hmg/ddl166

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Analysis of microsatellite markers and single nucleotide polymorphisms in candidate genes for susceptibility to bipolar affective disorder in the chromosome 12Q24.31 region

Autor: Ronald G. Lafrenière, Nicholas Barden, Bernard Gagné, Monique Tremblay, Marie-Pierre Dubé, Michel Labbé, Pascal Belleau, Mario Harvey, Catherine Raymond, Eric Shink

Publikováno v: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :50-58

Previous results from our genetic analyses using pedigrees from a French Canadian population suggested that the interval delimited by markers D12S86 and D12S378 on chromosome 12 was the most probable genomic region to contain a susceptibility gene fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29867d88e6e89241641119f6fe9cb073
https://doi.org/10.1002/ajmg.b.30165

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Support for the presence of bipolar disorder susceptibility loci on chromosome 5

Autor: Denis Rochette, Eric Shink, M. Plante, A Villeneuve, Carmen Laprise, Bernard Gagné, L. Bordeleau, Jean Morissette, Nicholas Barden

Publikováno v: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 26:1273-1277

A very large pedigree derived from the Saguenay-Lac-St-Jean region of Quebec contains a branch where a distal chromosome 5q haplotype seems to cosegregate with bipolar affective disorder. The authors used a diagnosis model where Bipolar Types I and I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2604721337a5f900c6bebe9b5f3ce200
https://doi.org/10.1016/s0278-5846(02)00266-x

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Genome-wide search for linkage of bipolar affective disorders in a very large pedigree derived from a homogeneous population in Quebec points to a locus of major effect on chromosome 12q23-q24

Autor: L. Bordeleau, Catherine Laprise, J Weissenbach, Gérard Bouchard, L Gobeil, Denis Rochette, Claude Laberge, Nicholas Barden, A Villeneuve, M. Plante, Eric Shink, Bernard Gagné, Jean Morissette

Publikováno v: American Journal of Medical Genetics. 88:567-587

We completed a genome-wide scan for susceptibility loci for bipolar affective disorders in families derived from a rather homogeneous population in the Province of Québec. The genetic homogeneity of this population stems from the migration of foundi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1866dddf837bf27369b2e783b4263e12
https://doi.org/10.1002/(sici)1096-8628(19991015)88:5<567::aid-ajmg24>3.0.co

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Exclusion of non-synonymous SNPs and a polyglutamine tract in SMRT/N-CoR2 as common deleterious mutation for bipolar disorder in the Sagnenay-Lac-St-Jean population

Autor: Nicholas Barden, Catherine Raymond, Michel Labbé, Mario Harvey, Bernard Gagné, Monique Tremblay, Eric Shink

Publikováno v: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :10-12

Bipolar disorder (BP) is a psychiatric illness with both genetic and environmental components occurring with a prevalence of slightly more than 1%. Our previous linkage and case/control studies have pointed to a susceptibility locus for BP in the 12q

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5dfa66ce08b39895ec4c0e71eb34e3b0
https://doi.org/10.1002/ajmg.b.30145

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Chronic estradiol treatment increases anterior pituitary but not striatal D2 dopamine receptor mRNA levels in rats

Autor: Daniel Lévesque, Thérèse Di Paolo, Bernard Gagné, Nicholas Barden

Publikováno v: Neuroscience Letters. 140:5-8

The effect of chronic 17 beta-estradiol treatment (10 micrograms, twice each day, for 2 weeks) of ovariectomized rats on D2 dopamine (DA) receptor mRNA levels was investigated in striatum and anterior pituitary gland tissues. We used 32P-labeled prob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6058440c4519c9e1b739f2e5b5349e9
https://doi.org/10.1016/0304-3940(92)90668-w

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Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder

Autor: Monique Tremblay, Catherine Raymond, Denis Rochette, Florian Holsboer, Michel Labbé, Mario Harvey, L. Bordeleau, Bernard Gagné, Nicholas Barden, A Villeneuve, Eric Shink, Herbert Stadler, Bertram Müller-Myhsok

Publikováno v: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. (4)

Previous results from our genetic analyses using pedigrees from a French Canadian population suggested that the interval delimited by markers on chromosome 12, D12S86 and D12S378, was the most probable genomic region to contain a susceptibility gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42ed50431472be61e52f3ec53843844
https://pubmed.ncbi.nlm.nih.gov/16673375

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Analysis of microsatellite markers and single nucleotide polymorphisms in candidate genes for susceptibility to bipolar affective disorder in the chromosome 12Q24.31 region

Autor: Eric, Shink, Mario, Harvey, Monique, Tremblay, Bernard, Gagné, Pascal, Belleau, Catherine, Raymond, Michel, Labbé, Marie-Pierre, Dubé, Ronald G, Lafrenière, Nicholas, Barden

Publikováno v: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. (1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::17f68db0fb28fe4dd70716a59372ae46
https://pubmed.ncbi.nlm.nih.gov/15768393

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Exclusion of non-synonymous SNPs and a polyglutamine tract in SMRT/N-CoR2 as common deleterious mutation for bipolar disorder in the Sagnenay-Lac-St-Jean population

Autor: Eric, Shink, Mario, Harvey, Monique, Tremblay, Catherine, Raymond, Michel, Labbé, Bernard, Gagné, Nicholas, Barden

Publikováno v: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. (1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f73ab507259d5caf25b92bfddd158f56
https://pubmed.ncbi.nlm.nih.gov/15635693

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