Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Bernard Françon"'
Autor:
Anthony Nichols, David Covini, Anna Quattropani, Jean-François Arrighi, Yves Cambet, Maurizio Maio, Thierry Martin, Olivier Schott, Bernard Françon, Laurence Novo-Perez, Don Simpson, Delphine Marin, Delphine Rivron, Cristina Donini, Agnes Bombrun, Pierre-Alain Vitte, Stefano Crosignani, Wolfgang H. B. Sauer, Isabelle Martinou, Dominique Swinnen, Valerie Eligert, Fabienne Burgat-Charvillon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1516-1519
The discovery of a novel series of S1P1 agonists is described. Starting from a micromolar HTS positive, iterative optimization gave rise to several single-digit nanomolar S1P1 agonists. The compounds were able to induce internalization of the S1P1 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016d011f2a43aa5c6d794dc932148d8b
https://doi.org/10.1016/j.bmcl.2010.01.102
https://doi.org/10.1016/j.bmcl.2010.01.102
Autor:
Dominique Perrin, Lara Joubert, Catherine Salvat, Isabelle Foucault, Bernard Françon, Hadi Abderrahim, Marc Lamarine, Catherine Jorand-Lebrun, Francisca Zanoguera, Rosanna Pescini Gobert, Marie Laure Curchod, Helene Peixoto, Agnes Bombrun, Lilia Bernasconi, Christian Rommel, Chantal Alliod, Rob Hooft van Huijsduijnen, Chloé Vignaud, Thérèse Jomotte, Christèle Frémaux
Publikováno v:
Molecular and cellular biology. 29(6)
Inadequate remyelination of brain white matter lesions has been associated with a failure of oligodendrocyte precursors to differentiate into mature, myelin-producing cells. In order to better understand which genes play a critical role in oligodendr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a373465acee59f9aaed35be0d56c6186
https://pubmed.ncbi.nlm.nih.gov/19139271
https://pubmed.ncbi.nlm.nih.gov/19139271
Autor:
Corinne Gillieron, Christian Chabert, Thomas Rückle, Jasna Klicic, Denise Gretener, Jeffrey P. Shaw, Karen Roulin, Didier Leroy, Fabienne Burgat-Charvillon, Dennis D. Church, Susanna Carboni, Matthias Schwarz, Delphine Valognes, Pierre Alain Vitte, Anthony Nichols, Bernard Françon, Vincent Pomel, Dominique Perrin, David Covini, Montserrat Camps, Christian Rommel
Publikováno v:
Journal of medicinal chemistry. 49(13)
Class I phosphoinositide 3-kinases (PI3Ks), in particular PI3Kgamma, have become attractive drug targets for inflammatory and autoimmune diseases. Here, we disclose a novel series of furan-2-ylmethylene thiazolidinediones as selective, ATP-competitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71fba637b877d4efe4f3d46410b3766d
https://pubmed.ncbi.nlm.nih.gov/16789742
https://pubmed.ncbi.nlm.nih.gov/16789742
Autor:
Christian Chabert, Denise Gretener, Pierre-Alain Vitte, Vittoria Ardissone, Thierry Martin, Hong Ji, Felix Rintelen, Matthias P. Wymann, Didier Leroy, Emilio Hirsch, Thomas Rückle, Jeffrey P. Shaw, Bernard Françon, Rocco Cirillo, Chiara Ferrandi, Montserrat Camps, Christian Rommel, Matthias Schwarz, Corine Gillieron, Dominique Perrin
Phosphoinositide 3-kinases (PI3K) have long been considered promising drug targets for the treatment of inflammatory and autoimmune disorders as well as cancer and cardiovascular diseases. But the lack of specificity, isoform selectivity and poor bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2debb95b3b44e7f1468b792323be117
http://hdl.handle.net/2318/40516
http://hdl.handle.net/2318/40516
