Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Bernard Foucaud"'
Publikováno v:
Cells, Vol 12, Iss 18, p 2249 (2023)
Intracranial hypertension (ICP) and visual impairment intracranial pressure (VIIP) are some of the sequels of long-term space missions. Here we sought to determine how space microgravity (µG) impacts the metabolomics profile of oligodendrocyte proge
Externí odkaz:
https://doaj.org/article/a6ba3e4e9a54463b91b7cc877d1f3c0b
Publikováno v:
Current Chemical Biology. 1:271-277
Publikováno v:
Journal of Medicinal Chemistry. 42:4394-4404
The glycine-binding site of the N-methyl-D-aspartate (NMDA) receptor, given its potential as pharmacological target, has been thoroughly studied by structure-activity relationships, which has made possible its description in terms of spatial limits a
Publikováno v:
Journal of Receptors and Signal Transduction. 19:547-557
The glycine co-agonist binding site of the NMDA receptor is a target for the prevention and treatment of neurotoxic and neurodegenerative conditions. Until now, the interactions taking place at this site, and its structure, have been investigated by
Publikováno v:
The Journal of Organic Chemistry. 58:1076-1082
The synthesis of novel photoactivatable 7Z,9E and 7E,9E dienic peptidoleukotriene derivatives has been investigated in order to design original and chemically stable photoaffinity probes for the peptidoleukotriene receptors. This new series was attai
Autor:
Bernard Foucaud, Giorgio Gombos
Publikováno v:
European Journal of Pharmacology: Molecular Pharmacology. 189:355-362
The kinetic and equilibrium binding parameters of the phencyclidine receptor ligand [3H]N-[1-(2-thienyl)cyclohexyl]piperidine (TCP) to a postsynaptic density (PSD) subcellular fraction from rat brain were investigated. A single site was found, which
Publikováno v:
Journal of Neurochemistry
Journal of Neurochemistry, Wiley, 2005, 93, pp.859-866
J. Neurochem.
J. Neurochem., 2005, 93, pp.859-866
Journal of Neurochemistry, Wiley, 2005, 93, pp.859-866
J. Neurochem.
J. Neurochem., 2005, 93, pp.859-866
Benzodiazepines are widely used for their anxiolytic, sedative, myorelaxant and anticonvulsant properties. They allosterically modulate GABA(A) receptor function by increasing the apparent affinity of the agonist GABA. We studied conformational chang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1993e2dbcdd9fdf6120d8e1c786be765
https://hal.archives-ouvertes.fr/hal-00129812
https://hal.archives-ouvertes.fr/hal-00129812
Autor:
Heinrich Betz, Annett Kreimeyer, Bernard Foucaud, Maurice Goeldner, Bodo Laube, Rudolf Schemm
Publikováno v:
The Journal of biological chemistry. 278(26)
The N-methyl-d-aspartate (NMDA) receptor is a ligand-gated ion channel that requires both glutamate and glycine for efficient activation. Here, a strategy combining cysteine scanning mutagenesis and affinity labeling was used to investigate the glyci
Publikováno v:
Journal of receptor and signal transduction research. 22(1-4)
To investigate the topology of binding sites in two ionotropic receptors, we have initiated a strategy combining affinity labeling with cysteine-scanning mutagenesis. For the GABAA receptor we have used reactive derivatives of non-competitive blocker
Publikováno v:
Trends in pharmacological sciences. 22(4)
The incorporation of cysteine residues into membrane receptors by mutagenesis has enabled the development of engineered proteins. Chemical modification of the mutant receptor using a wide range of biochemical and biophysical probes has facilitated fu