Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Bernard D. Lemire"'
Autor:
Bernard D. Lemire, Priya Uppuluri
Insertion and deletion mutations (indels) are important mechanisms of generating protein diversity. Indels in coding sequences are under considerable selective pressure to maintain reading frames and to preserve protein function, but once generated,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72fbf8d38ed73d1a4c3fa84c0a0f1890
https://doi.org/10.1101/2023.04.06.535715
https://doi.org/10.1101/2023.04.06.535715
Publikováno v:
BioTechniques, Vol 50, Iss 1, Pp 58-63 (2011)
New antifungal agents are needed to treat life-threatening fungal infections, particularly with the development of resistance. Surface-active antifungals have the advantages of minimizing host toxicity and the emergence of drug resistance. We have de
Externí odkaz:
https://doaj.org/article/a95dcce452194102939b5644b4caca76
Autor:
Bernard D. Lemire
Publikováno v:
Mitochondrion. 35:13-22
The NADH:ubiquinone oxidoreductase (complex I) is the largest member of the mitochondrial respiratory chain. Its FMN cofactor accepts two electrons from NADH and transfers them to ubiquinone via a chain of iron-sulphur centers. A central core of 14 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a48203fe0bc1bbed3408e14e02c905
https://doi.org/10.1016/j.mito.2017.04.005
https://doi.org/10.1016/j.mito.2017.04.005
Autor:
Zeinab Mamouei, Yiyou Gu, Shakti Singh, Dongmei Li, Bernard D. Lemire, Ashraf S. Ibrahim, Sunna Nabeela, Abdullah Alqarihi, Priya Uppuluri
Publikováno v:
PLoS biology, vol 19, iss 3
PLoS Biology, Vol 19, Iss 3, p e3000957 (2021)
PLoS Biology, Vol 19, Iss 3, p e3000957 (2021)
A forward genetic screening approach identified orf19.2500, as a gene controlling Candida albicans biofilm dispersal and biofilm detachment. Three-dimensional (3-D) protein modeling and bioinformatics revealed that orf19.2500 is a conserved mitochond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3b5a486223f1777fa9943844409307
https://doi.org/10.1371/journal.pbio.3000957
https://doi.org/10.1371/journal.pbio.3000957
Publikováno v:
Journal of Biological Chemistry. 287:22509-22520
Succinate dehydrogenase (SDH), also known as complex II, is required for respiratory growth; it couples the oxidation of succinate to the reduction of ubiquinone. The enzyme is composed of two domains. A membrane-extrinsic catalytic domain composed o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::194497713820f7df34cd00f5fb05344f
https://doi.org/10.1074/jbc.m112.344275
https://doi.org/10.1074/jbc.m112.344275
Publikováno v:
BioTechniques. 50:58-63
New antifungal agents are needed to treat life-threatening fungal infections, particularly with the development of resistance. Surface-active antifungals have the advantages of minimizing host toxicity and the emergence of drug resistance. We have de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4292a01af363ad55e511f2b74bababe9
https://doi.org/10.2144/000113568
https://doi.org/10.2144/000113568
Publikováno v:
Journal of Proteome Research. 9:6729-6739
Metabolomics is a powerful method of examining the intricate connections between mutations, metabolism, and disease. Metabolic footprinting examines the extracellular metabolome or exometabolome. We employed NMR-based metabolic footprinting and multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971ba5a18bc1d69dcb0e79adf6fc9451
https://doi.org/10.1021/pr100880y
https://doi.org/10.1021/pr100880y
Publikováno v:
Mechanisms of Ageing and Development. 130:461-465
Energy production via oxidative phosphorylation generates a mitochondrial membrane potential (DeltaPsi(m)) across the inner membrane. In this work, we show that a lower DeltaPsi(m) is associated with increased lifespan in Caenorhabditis elegans. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12fc6feae532de5a405239fb16303f3
https://doi.org/10.1016/j.mad.2009.05.001
https://doi.org/10.1016/j.mad.2009.05.001
Autor:
Bernard D. Lemire, Jingzhou Huang
Publikováno v:
Journal of Molecular Biology. 387:559-569
The mitochondrial succinate dehydrogenase (SDH) is an iron–sulfur flavoenzyme linking the Krebs cycle and the mitochondrial respiratory chain. Mutations in the human SDHB, SDHC and SDHD genes are responsible for the development of paraganglioma and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757e0c6ebf1568eaa5f7d2670357bd38
https://doi.org/10.1016/j.jmb.2009.02.028
https://doi.org/10.1016/j.jmb.2009.02.028
Publikováno v:
Journal of Biological Chemistry. 282:27518-27526
The mitochondrial succinate dehydrogenase (SDH) is an essential component of the electron transport chain and of the tricarboxylic acid cycle. Also known as complex II, this tetrameric enzyme catalyzes the oxidation of succinate to fumarate and reduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64fcc1971deea3c91d64684d882b0458
https://doi.org/10.1074/jbc.m700601200
https://doi.org/10.1074/jbc.m700601200