Výsledky vyhledávání - "Bernard Cote"

Akademický článek

Fouqueure (Charente). La Terne, l’aqueduc de la Font du Frêne

Autor: Daniel Bernardin, Claude Brege, Bernard Cote

Publikováno v: Archéologie Médiévale, Vol 35 (2005)

Externí odkaz: https://doaj.org/article/00b85a05416b48deb5674553734437d9

In Vitro Characterization of MK-1439, a Novel HIV-1 Nonnucleoside Reverse Transcriptase Inhibitor

Autor: Jay A. Grobler, Meizhen Feng, Yuan Li, Yves Ducharme, Jean-Pierre Falgueyret, Bernard Cote, Youwei Yan, Louis-Charles Campeau, Ernest Asante-Appiah, Ming-Tain Lai, Jason Burch, Marc V. Witmer, Daria J. Hazuda, Michael D. Miller, Nancy A. Sachs, Elizabeth Cauchon, Paul Tawa, Daniel J. DiStefano, Meiqing Lu

Publikováno v: Antimicrobial Agents and Chemotherapy. 58:1652-1663

Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are a mainstay of therapy for treating human immunodeficiency type 1 virus (HIV-1)-infected patients. MK-1439 is a novel NNRTI with a 50% inhibitory concentration (IC 50 ) of 12, 9.7, and 9.7 nM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031e80e91b45808e18f50cd354a2ad72
https://doi.org/10.1128/aac.02403-13

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Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:5837-5841

Phenanthrene imidazoles 26 and 44 have been identified as novel potent, selective and orally active mPGES-1 inhibitors. These inhibitors are significantly more potent than the previously reported chlorophenanthrene imidazole 1 (MF63) with a human who

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::211648f4f7f71bac98c75cfd8336367c
https://doi.org/10.1016/j.bmcl.2009.08.085

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2,3-Diarylthiophenes as selective EP1 receptor antagonists

Autor: Richard Friesen, Gillian Greig, Nicole Sawyer, Bernard Cote, Stacia Kargman, Sonia Lamontagne, Kathleen M. Metters, Richard Frenette, Yves Ducharme, Gary P. O'Neill, François Nantel, Marie-Claude Carrière, Evelyn Martins, Anne Chateauneuf, Danielle Denis, Marc Blouin

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 15:1155-1160

The synthesis and the EP(1) receptor binding affinity of 2,3-diarylthiophene derivatives are described. The evaluation of the structure-activity relationship (SAR) in this series led to the identification of compounds 4, 7, and 12a, which exhibit hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6f402fb1f8a89c49cba4bad65f5f76
https://doi.org/10.1016/j.bmcl.2004.12.005

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Trisubstituted ureas as potent and selective mPGES-1 inhibitors

Publikováno v: Bioorganicmedicinal chemistry letters. 21(5)

A novel series of trisubstituted ureas has been identified as potent and selective mPGES-1 inhibitors. These compounds are selective over other prostanoid enzymes such as PGF synthase and TX synthase. This series of inhibitors was developed by lead o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de1691bd51a043c16bf604bc6ba03e2
https://pubmed.ncbi.nlm.nih.gov/21295979

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MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation

Autor: Andre Giroux, Laurent P. Audoly, Daigen Xu, Yves Ducharme, Denis Riendeau, Sébastien Guiral, Bernard Cote, Richard Friesen, Joseph A. Mancini, Myriam Salem, Steven E. Rowland, Patsy Clark, Nathalie Méthot

Publikováno v: The Journal of pharmacology and experimental therapeutics. 326(3)

Microsomal prostaglandin E synthase-1 (mPGES-1) is a terminal prostaglandin E(2) (PGE(2)) synthase in the cyclooxygenase pathway. Inhibitors of mPGES-1 may block PGE(2) production and relieve inflammatory symptoms. To test the hypothesis, we evaluate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e3be288aa8ba65ca14cb0f9ff6a395
https://pubmed.ncbi.nlm.nih.gov/18524979

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Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors

Publikováno v: Bioorganicmedicinal chemistry letters. 17(24)

Phenanthrene imidazole 3 (MF63) has been identified as a novel potent, selective, and orally active mPGES-1 inhibitor. This new series was developed by lead optimization of a hit from an internal HTS campaign. Compound 3 is significantly more potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb349ba84d5e91a0c8a43ee5b2f580fe
https://pubmed.ncbi.nlm.nih.gov/18029174

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Pharmacological characterization of a selective COX-2 inhibitor MF-tricyclic, [3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone], in multiple preclinical species

Autor: Lynn Dufresne, Chi-Chung Chan, Anne K. Mullen, Jocelyne Guay, Daigen Xu, Bernard Cote, Christine Brideau, Joseph A. Mancini, R. Gordon, Steven E. Rowland, Laurent P. Audoly, Yves Ducharme, Patsy Clark

Publikováno v: European journal of pharmacology. 560(2-3)

Selective type 2 cyclooxygenase (COX-2) inhibitors are often used in preclinical studies without potency and selectivity data in the experimental species. To address this issue, we assessed a selective COX-2 inhibitor MF-tricyclic in four commonly us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e79920791bb77e7ca711a2e2cea939af
https://pubmed.ncbi.nlm.nih.gov/17316604

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