Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Bernard Calandra"'
Autor:
Monique Delpech, Pascual Ferrara, David Shire, Marielle Portier, Aimée Kernéis, Christine Carillon, Gérard Le Fur, Bernard Calandra
Publikováno v:
European Journal of Pharmacology. 374:445-455
It has long been established that the cannabinoid CB1 receptor transduces signals through a pertussis toxin-sensitive Gi/Go inhibitory pathway. Although there have been reports that the cannabinoid CB1 receptor can also mediate an increase in cyclic
Autor:
M. Portier, Laura Milligan, Francis Barth, Johannes Lupker, Pierre Casellas, Florence Pecceu, Xavier Canat, Gérard Le Fur, Sylvie Perrachon, Jean-Pierre Maffrand, Murielle Rinaldi-Carmona, Monsif Bouaboula, Bernard Calandra
Publikováno v:
Journal of Biological Chemistry. 272:22330-22339
In the present study, we showed that Chinese hamster ovary (CHO) cells transfected with human central cannabinoid receptor (CB1) exhibit high constitutive activity at both levels of mitogen-activated protein kinase (MAPK) and adenylyl cyclase. These
Publikováno v:
Biotechnology Letters. 19:425-428
The human central CB1 and peripheral CB2 cannabinoid receptors were expressed in Escherichia coli as fusion proteins with the maltose-binding protein at their amino-termini and a hexa-histidine/Flag tag at their carboxyl-termini. Western blot analysi
Autor:
Pascual Ferrara, David Shire, Daniel Caput, Bernard Calandra, Odile Bonnin-Cabanne, Gérard Le Fur, Murielle Rinaldi-Carmona, Didier Oustric, Bernard Pessegue
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1307:132-136
We have cloned the peripheral cannabinoid receptor, mCB2, from a mouse splenocyte cDNA library. The 3.7 kb sequence contains an open reading frame encoding a protein of 347 residues sharing 82% overall identity with the only other known peripheral re
Autor:
Caroline Poinot-Chazel, Jean Marchand, Pierre Casellas, Xavier Canat, Bernard Calandra, Gérard Le Fur, Murielle Rinaldi-Carmona, Monsif Bouaboula, Bernard Bourrie
Publikováno v:
European Journal of Biochemistry. 237:704-711
Cannabinoids, known for their psychoactive effects, also possess immunomodulatory properties. The recent isolation and cloning of the G-protein-coupled peripheral cannabinoid receptor (CB2), mainly expressed in immune tissues, have provided molecular
Autor:
Daniel Caput, Bernard Calandra, David Shire, Mourad Kaghad, Murielle Rinaldi-Carmona, Christine Carillon, Pascual Ferrara, Gérard Le Fur
Publikováno v:
Journal of Biological Chemistry. 270:3726-3731
The cDNA sequences encoding the central cannabinoid receptor, CB1, are known for two species, rat and human. However, little information concerning the flanking, noncoding regions is presently available. We have isolated two overlapping clones from a
Autor:
David Shire, J. C. Breliere, Daniel Caput, Francis Barth, Michel Heaulme, P. Ferrara, Gérard Le Fur, Murielle Rinaldi-Carmona, Christian Congy, Jeanne Maruani, Serge Martinez, Philippe Soubrie, Bernard Calandra, Gervais Neliat
Publikováno v:
FEBS Letters. 350:240-244
SR141716A is the first selective and orally active antagonist of the brain cannabinoid receptor. This compound displays nanomolar affinity for the central cannabinoid receptor but is not active on the peripheral cannabinoid receptor. In vitro, SR1417
The cannabinoid receptors and their interactions with synthetic cannabinoid agonists and antagonists
Autor:
Pierre Casellas, Pascual Ferrara, Murielle Rinaldi-Carmona, Paul R. Gouldson, Monsif Bouaboula, David Shire, Gérard Le Fur, Francis Barth, Bernard Calandra, Marielle Portier
Publikováno v:
The Biology of Marijuana ISBN: 9780415273480
Here we describe the characteristics of the cannabinoid receptor subtypes, CB1 and CB2, and what we know of their interactions with certain ligands. CB1 and CB2 are members of the superfamily of 7 transmembrane domain (7TM) receptors that transduce i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b36bd15b87e7f7f3383258bd1f21f3fd
https://doi.org/10.1201/9780203219133.ch21
https://doi.org/10.1201/9780203219133.ch21
Autor:
Francis Barth, Pascale Legoux, Murielle Rinaldi-Carmona, David Shire, Bernard Calandra, Paul R. Gouldson, Pascual Ferrara, Aimée Kernéis, Gérard Le Fur
Publikováno v:
European journal of pharmacology. 401(1)
We have investigated the binding site of the subtype specific antagonist SR 144528, (N-[(1S)-endo-1,3,3-trimethyl bicyclo [2.2. 1]heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methoxybenzyl)- pyrazo le-3-carboxamide) on the human cannabinoid CB(2) re
Autor:
Murielle Rinaldi-Carmona, Bernard Calandra, Francis Barth, Pierre Casellas, Pascual Ferrara, David Shire, Monsif Bouaboula
Publikováno v:
Life sciences. 65(6-7)
The G protein-coupled cannabinoid receptor subtypes CB1 and CB2 have been cloned from several species. The CB1 receptor is highly conserved across species, whereas the CB2 receptor shows considerable cross-species variations. The two human receptors