Výsledky vyhledávání - "Bernard C. Zook"

Cloning, Yeast Expression, Isolation, and Vaccine Testing of RecombinantAncylostoma‐Secreted Protein (ASP)–1 and ASP‐2 fromAncylostoma ceylanicum

Autor: Bin Zhan, Sophia Chung-Debose, Alex Loukas, Sen Liu, Gaddam Goud, Vehid Deumic, Reshad Dobardzic, Susana Mendez, Kashinath Ghosh, Laura Hoffman, Rachna Patel, Yueyuan Liu, Peter J. Hotez, Azra Dobardzic, Qun Jin, Bernard C. Zook, John M. Hawdon

Publikováno v: The Journal of Infectious Diseases. 189:919-929

cDNAs encoding 2 Ancylostoma-secreted proteins (ASPs), Ancylostoma ceylanicum (Ay)-ASP-1 and Ay-ASP-2, were cloned from infective third-stage larvae (L3) of the hookworm A. ceylanicum and were expressed as soluble recombinant fusion proteins secreted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48075c8ca3c984ae7838b14b2b3151d6
https://doi.org/10.1086/381901

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Natural History of Primary Canine Hookworm Infections After Three Different Oral Doses of Third-Stage Infective Larvae of Ancylostoma caninum

Autor: Jeffrey M. Bethony, Qun Jin, Peter J. Hotez, Bernard C. Zook, Heather A. Young, Richard A. Hitzelberg, Samuel J. Simmens, John M. Hawdon, Zhan Bin

Publikováno v: Comparative Parasitology. 69:72-80

The clinical courses of 6 canine hookworm infections were examined in 19–20-wk-old dogs infected with 400, 600, or 800 third-stage infective larvae (L3) of Ancylostoma caninum. Dogs infected with 600 L3 exhibited the greatest adult hookworm burden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed89bad79c9cb409a2e7a0edeb561127
https://doi.org/10.1654/1525-2647(2002)069[0072:nhopch]2.0.co

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The Development and Regression of Deciduosarcomas and Other Lesions Caused by Estrogens and Progestins in Rabbits

Autor: A. Andrew Abraham, Bernard C. Zook, Olli A. Jänne, Harold A. Nash

Publikováno v: Toxicologic Pathology. 29:411-416

A series of experiments were conducted to study the histopathological effects of a combination of exogenous estrogens and progestins in mature rabbits. Estradiol (14—45 μ g/day) and levonorgestrel (30—233 μg/day) were administered by intravagin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dffbc6909ad12145b73c1d75ed5e8e2
https://doi.org/10.1080/01926230152499755

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Evaluation of ENU-Induced Gliomas in Rats: Nomenclature, Immunochemistry, and Malignancy

Autor: Samuel J. Simmens, Bernard C. Zook, Robert V. Jones

Publikováno v: Toxicologic Pathology. 28:193-201

Rats developed mixed gliomas, oligodendrogliomas, and a few astrocytomas in response to transplacental ethylnitrosourea. The neoplastic cell composition of mixed gliomas must be defined; this study required a 20-80% admixture of neoplastic astrocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74caa2156c15cc383243c82ec23deff7
https://doi.org/10.1177/019262330002800124

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Virulence of Mycobacterium tuberculosis CDC1551 and H37Rv in Rabbits Evaluated by Lurie’s Pulmonary Tubercle Count Method

Autor: Ping Chen, Nikki M. Parrish, James W. Boles, Walter L. Johnson, William R. Bishai, Arthur M. Dannenberg, M. Louise M. Pitt, Rafael Ruiz, Bernard C. Zook

Publikováno v: Infection and Immunity. 67:4931-4934

The virulence of the CDC1551 strain of Mycobacterium tuberculosis was compared to that of H37Rv in a rabbit inhalation model. While rabbits that inhaled the two strains produced equal numbers of grossly visible primary tubercles, CDC1551 tubercles we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592d8eb0bd4cb2010e6997ad7d87fa8a
https://doi.org/10.1128/iai.67.9.4931-4934.1999

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The effects of pulsed 860 MHz radiofrequency radiation on the promotion of neurogenic tumors in rats

Autor: Bernard C. Zook, Samuel J. Simmens

Publikováno v: Radiation research. 165(5)

In a previous study, this laboratory reported a statistically nonsignificant trend for shortened latency of ethylnitrosourea (ENU)-induced brain tumors in Sprague-Dawley rats exposed to an 860 MHz pulsed radiofrequency (RF) signal. The present study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809a08f9568ad98306d6f169310d8988
https://pubmed.ncbi.nlm.nih.gov/16669743

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Neurogenic tumors in rats induced by ethylnitrosourea

Autor: Samuel J. Simmens, Bernard C. Zook

Publikováno v: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 57(1)

Ethylnitrosourea (ENU) was injected intravenously into Sprague-Dawley rats on day 15 of gestation at doses of 0, 2.50, 6.25 and 10.00 mg/kg. The resulting 1980 progeny were observed for up to 24 months in a life-time study (900 rats) or for periods o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4897e71a4ea240fedbe1e0a8b0c03edc
https://pubmed.ncbi.nlm.nih.gov/16089315

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Susceptibility to Tuberculosis: Clues from Studies with Inbred and Outbred New Zealand White Rabbits

Autor: Susan E. Dorman, Sandeep Tyagi, Bernard C. Zook, William R. Bishai, Arthur M. Dannenberg, Javier Lopez-Molina, Yukari C. Manabe, Katherine M. Aird, M. Louise M. Pitt, Christine L. Hatem

The rabbit model of tuberculosis (TB) is important because rabbits develop a disease that is similar to TB in humans, namely, granulomas with caseous necrosis, liquefaction, and cavities. We describe here a comparison of inbred and outbred New Zealan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b5588de6d47c7015237725e4a82616
https://europepmc.org/articles/PMC415726/

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Effect of vaccination with a recombinant fusion protein encoding an astacinlike metalloprotease (MTP-1) secreted by host-stimulated Ancylostoma caninum third-stage infective larvae

Autor: Philip K. Russell, Qun Jin, Jeffrey M. Bethony, Reshad Dobardzic, Yang Wang, Brian E. Howard, Bernard C. Zook, Idong Essiet, Azra Dobardzic, Janelle Bolden, James Ashcom, Bin Zhan, John M. Hawdon, Alex Loukas, Walter E. Brandt, Peter J. Hotez, Marco Chacon, Karen Jones

Publikováno v: The Journal of parasitology. 89(4)

Laboratory dogs were vaccinated intramuscularly with a recombinant fusion protein (expressed and isolated from Escherichia coli) formulated with the Glaxo SmithKline Adjuvant System 02 (AS02). The fusion protein encoded Ac-MTP-1, a developmentally re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd432ce08506abf0e4b419988f0134e2
https://pubmed.ncbi.nlm.nih.gov/14533704

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Different strains of Mycobacterium tuberculosis cause various spectrums of disease in the rabbit model of tuberculosis

Autor: Sandeep Tyagi, Arthur M. Dannenberg, M. Louise M. Pitt, Yukari C. Manabe, Mark Yoder, Bernard C. Zook, William R. Bishai, Christine L. Hatem, Samuel C. Woolwine

Publikováno v: Infection and immunity. 71(10)

The rabbit model of tuberculosis has been used historically to differentiate betweenMycobacterium tuberculosisandMycobacterium bovisbased on their relative virulence in this animal host.M. tuberculosisinfection in market rabbits is cleared over time,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc478783f8a865eef91360d47df044d7
https://pubmed.ncbi.nlm.nih.gov/14500521

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