Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Bernard Bruguerolle"'
Autor:
Véronique Brevaut-Malaty, Amélie Marsot, Bernard Bruguerolle, Nicolas Simon, Audrey Boulamery, Renaud Vialet
Publikováno v:
Fundamental & Clinical Pharmacology. 28:465-471
Phenobarbital is widely used for treatment of neonatal seizures. Its optimal use in neonates and young infants requires information regarding pharmacokinetics. The objective of this study is to characterize the absolute bioavailability of phenobarbit
Publikováno v:
Fundamental & Clinical Pharmacology. 28:144-150
Ertapenem is a parenteral broad-spectrum carbapenem active against Gram-negative pathogens, which has been approved for treatment of different infectious situations in adults and children. Favourable pharmacokinetics and pharmacodynamics have been es
Publikováno v:
Clinical Pharmacokinetics. 51:787-798
Three decades after its introduction, pharmacokinetic population approaches have become a reference method for drug modelling, particularly in paediatrics. The main practical limitation in this specific population is the collected blood volume. Pharm
Publikováno v:
Clinical Pharmacology in Drug Development. 1:144-151
Introduction: Model evaluation is an important issue in population pharmacokinetic analyses. The objectives were to evaluate the predictive performance of previously published pediatric population pharmacokinetic models for vancomycin in a new data s
Autor:
Bernard Bruguerolle, Philippe Brunet, Nicolas Simon, Christa Roubicek, Yvon Berland, Kassim Papa
Publikováno v:
Néphrologie & Thérapeutique. 6:576-580
Resume Introduction La persistance de residus de fabrication dans les hemodialyseurs est un aspect neglige du manque de biocompatibilite de l’hemodialyse. L’effet de ces residus de fabrication a ete teste sur des mitochondries isolees de foie de
Autor:
Audrey Boulamery, Elisabeth Deturmeny, Romain Guilhaumou, Bénédicte Deluca, Bernard Bruguerolle
Publikováno v:
Fundamental & Clinical Pharmacology. 24:463-468
Ropivacaine is a local anaesthetic used for epidural anaesthesia and postoperative pain relief. Hyperthermia is a very common sign of infection associated with variations in physiological parameters, which may influence drugs pharmacokinetics. The ai
Autor:
Jean-Pierre Auffray, Djillali Annane, Bernard Bruguerolle, Mathieu Coulange, Alain Barthélémy, Jacques Bessereau, Nicolas Genotelle, Pierre Michelet
Publikováno v:
Therapies. 63:419-423
Resume Objectif Une grande partie du traitement medical adjuvant de l’accident de desaturation (ADD) repose sur l’administration d’aspirine, le plus precocement possible. Nous avons cherche sur quelles donnees s’appuyaient ces pratiques thera
Autor:
Nicolas Simon, Bernard Bruguerolle, Romain Guilhaumou, Emmanuelle Rocher, Audrey Boulamery, Hafedh Marouani
Publikováno v:
Fundamental & Clinical Pharmacology. 22:285-289
The aim of this study was to document the influence of hyperthermia on the pharmacokinetics of ertapenem. Two groups of Wistar rats, normothermic (n = 6) and hyperthermic (n = 8), were injected a single intravenous bolus of ertapenem (15 mg/kg of bod
Publikováno v:
Journal of Pharmaceutical Sciences. 97:1099-1108
Biological rhythms may influence drug response (chronopharmacology) and some chronopharmacological studies have underlined the influence of time of day on drug pharmacodynamics and pharmacokinetics. The aim of the present review is to underline how b
Autor:
Bernard Bruguerolle, Gaston Labrecque
Publikováno v:
Advanced Drug Delivery Reviews. 59:883-895
Pain control is one of the most important therapeutic priorities; nonetheless, inadequate pain relief remains a significant health care issue. Thus, it is important to determine whether the analgesic effect can be improved by using the chronopharmaco