Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Bernard B. Davis"'
Publikováno v:
Chemical Research in Toxicology. 14:312-318
A close association has been reported for certain types of cancers influenced by aromatic amines and infection/inflammation. Reactive nitric oxygen species (RNOS), components of the inflammatory response, are bactericidal and tumoricidal, and contrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbae780c0ba1971b9ee87c7b7f967212
https://doi.org/10.1021/tx0001676
https://doi.org/10.1021/tx0001676
Publikováno v:
Chemical Research in Toxicology. 13:891-899
Nitrating reactive nitric oxygen species (RNOS) elicit many of the deleterious effects of the inflammatory response. Their high reactivity and short half-life make RNOS analysis difficult. Reaction of acetaminophen (APAP) with RNOS generated by vario
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3c8be6bd8e5381329ef52aa93c9dd5
https://doi.org/10.1021/tx000115g
https://doi.org/10.1021/tx000115g
Publikováno v:
Chemical Research in Toxicology. 13:785-792
N'-(3'-Monophosphodeoxyguanosin-8-yl)-N-acetylbenzidine (dGp-ABZ) is the major adduct in exfoliated urothelial cells and in peripheral white blood cells of workers exposed to benzidine. This study was designed to assess the metabolic pathways leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b318eb95488228601c001e029e560f
https://doi.org/10.1021/tx0000320
https://doi.org/10.1021/tx0000320
Autor:
Terry V. Zenser, Marco Ciotti, Vijaya M. Lakshmi, Nikhil K. Basu, Ida S. Owens, Bernard B. Davis
Publikováno v:
Carcinogenesis. 20:1963-1969
Although glucuronidation is considered a necessary step in aromatic amine-induced bladder cancer, the specific enzymes involved are not known. This study assessed the capacity of five different human recombinant UDP-glucuronosyltransferases expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626d5ed9ca09134bab8b59f743ba6496
https://doi.org/10.1093/carcin/20.10.1963
https://doi.org/10.1093/carcin/20.10.1963
Publikováno v:
Journal of Biological Chemistry. 274:14850-14856
Synthesis of prostaglandin H2 by prostaglandin H synthase (PHS) results in a two-electron oxidation of the enzyme. An active reduced enzyme is regenerated by reducing cofactors, which become oxidized. This report examines the mechanism by which PHS f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea313a150bf7ab4485b3d79b12630a7d
https://doi.org/10.1074/jbc.274.21.14850
https://doi.org/10.1074/jbc.274.21.14850
Autor:
Richard B. Hayes, Nathaniel Rothman, Terry V Zenzer, S. K. Kashyap, Qing Zhou, Rekha Kashyap, Bernard B. Davis, Glenn Talaska, V. K. Bhatnagar, Vijay M Lakshmi, Dinesh J Parikh, Mustafa Dosemeci, Marlene Jaeger, Fong F. Hsu
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 393:199-205
In a cross-sectional study of 33 workers exposed to benzidine and benzidine dyes and 15 non-exposed controls, we previously reported that exposure status and internal dose of benzidine metabolites were strongly correlated with the levels of specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abea324337037bc1542f011e234c1f5f
https://doi.org/10.1016/s1383-5718(97)00097-1
https://doi.org/10.1016/s1383-5718(97)00097-1
Autor:
Michael B. Mattammal, Terry V. Zenser, Bernard B. Davis, F. F. Hsu, Nathan T. Zenser, Vijaya M. Lakshmi
Publikováno v:
Carcinogenesis. 17:1941-1947
This study used liver microsomes from control an naphthoflavone-treated rats to evaluate NADPH-dependent oxidation of benzidine. With microsomes from beta-naphthoflavone-treated rats, the rates of formation of aqueous soluble metabolite (HPLC analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab9ee39a6a98f419962d75b444d0c7e
https://doi.org/10.1093/carcin/17.9.1941
https://doi.org/10.1093/carcin/17.9.1941
Publikováno v:
Biochemical Pharmacology. 51:1679-1685
Glucuronide conjugates of arylamines are thought to be important in the carcinogenic process. This study investigated the pH stability and synthesis of glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolites by human and dog liver. Bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af4fab03f4a6334dfdba0624ca191edb
https://doi.org/10.1016/0006-2952(96)00165-7
https://doi.org/10.1016/0006-2952(96)00165-7
Publikováno v:
Carcinogenesis. 16:1565-1571
The extent to which N-acetylbenzidine and N,N'-diacetylbenzidine are formed may influence benzidine-induced carcinogenesis. This study compared the formation of these metabolites by rat and human liver slices. The relationship between the NAT2 genoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411d44ee66244fb5a82d2b15e8b00477
https://doi.org/10.1093/carcin/16.7.1565
https://doi.org/10.1093/carcin/16.7.1565