Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Bernard A. MacLeod"'
Autor:
Desmond H. Fung, Alasdair M. Barr, Ernest Puil, Timothy Fung, Stephan K. W. Schwarz, Yahya I. Asiri, Bernard A. MacLeod
Publikováno v:
Canadian Journal of Anesthesia/Journal canadien d'anesthésie. 68:672-682
There exists a pressing need for the identification of novel analgesics. We recently reported on a new preclinical assay for rapid analgesic screening based on intraplantar (i.pl.) injection of 10% hypertonic saline (HS) in female outbred (CD-1) mice
Publikováno v:
Drug Design, Development and Therapy. 14:3351-3361
Background Legalization of cannabis encourages the development of specific cultivars to treat disease such as neuropathic pain. Because of the large number of cultivars, it is necessary to prioritize extracts before proceeding to clinical trials. Pur
Autor:
Yahya I, Asiri, Desmond H, Fung, Timothy, Fung, Alasdair M, Barr, Ernest, Puil, Stephan K W, Schwarz, Bernard A, MacLeod
Publikováno v:
Canadian journal of anaesthesia = Journal canadien d'anesthesie. 68(5)
There exists a pressing need for the identification of novel analgesics. We recently reported on a new preclinical assay for rapid analgesic screening based on intraplantar (i.pl.) injection of 10% hypertonic saline (HS) in female outbred (CD-1) mice
Publikováno v:
Drug Design, Development and Therapy
Background Legalization of cannabis encourages the development of specific cultivars to treat disease such as neuropathic pain. Because of the large number of cultivars, it is necessary to prioritize extracts before proceeding to clinical trials. Pur
Autor:
David A. Saint, Richard A. Wall, Bernard A. MacLeod, Michael J A Walker, G. Adaikan, Alan L. Goldin, G.N. Beatch, Eric S. Hayes, Michael K. Pugsley, Shlomo Abraham
Publikováno v:
Biomedicine & Pharmacotherapy. 106:510-522
Background RSD921, the R,R enantiomer of the kappa (k) agonist PD117,302, lacks significant activity on opioid receptors. Methods The pharmacological and toxicological actions were studied with reference to cardiovascular, cardiac, antiarrhythmic, to
Antinociception by intrathecal delivery of the novel non-opioid 1-amino-1-cyclobutanecarboxylic acid
Autor:
Yahya I. Asiri, Richard A. Wall, Ernest Puil, Kamyar Taheri, Bernard A. MacLeod, Stephan K. W. Schwarz, Timothy Fung
Publikováno v:
European Journal of Pain. 23:260-271
Background Neuraxial opioids are widely used for intraoperative and post-operative analgesia. The risk of severe adverse effects including respiratory depression accompanies this analgesia, prompting the need for effective non-opioid alternatives. Sy
Autor:
Ian Welch, Bernard A. MacLeod, Timothy Fung, Alasdair M. Barr, Khalid A Asseri, Yahya I. Asiri, Catherine A. Schuppli, Stephan K. W. Schwarz, Richard A. Wall, Ernest Puil
Publikováno v:
Anesthesia & Analgesia. 127:548-555
BACKGROUND Development of new analgesics is limited by shortcomings of existing preclinical screening assays such as wide variations in response, suitability for a narrow range of analgesics, and propensity to induce tissue damage. Our aim was to det
Autor:
Timothy Fung, Richard A. Wall, Stephan K. W. Schwarz, Yahya I. Asiri, Bernard A. MacLeod, Ernest Puil
Publikováno v:
Amino Acids. 49:1203-1213
Current centrally acting analgesics such as opioids are associated with adverse effects that limit their use and threaten patient safety. Isovaline is a novel prototype analgesic that produces peripheral antinociception in several pain models with li
Autor:
Ernest Puil, Yahya I. Asiri, Richard A. Wall, Bernard A. MacLeod, Khalid A Asseri, Stephan K. W. Schwarz, Timothy Fung
Publikováno v:
European Journal of Pharmacology. 791:85-90
R-isovaline is a non-proteinogenic amino acid which produces analgesia in a range of nociceptive assays. Mediation of this effect by metabotropic receptors for γ-aminobutyric acid (GABA) and glutamate, demonstrated by previous work, may depend on th
Autor:
Yahya I. Asiri, Bernard A. MacLeod, Stephan K. W. Schwarz, Ryan A. Whitehead, Ernest Puil, Timothy Fung
Publikováno v:
Anesthesia & Analgesia. 121:1481-1487
BACKGROUND The combination of propofol and an opioid analgesic is widely used for procedural sedation, as well as total IV anesthesia. However, opioids produce respiratory depression, a primary cause of death due to these agents. We recently reported