Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Bernard A. Connolly"'
Publikováno v:
Archaea, Vol 2016 (2016)
In Archaea repair of uracil and hypoxanthine, which arise by deamination of cytosine and adenine, respectively, is initiated by three enzymes: Uracil-DNA-glycosylase (UDG, which recognises uracil); Endonuclease V (EndoV, which recognises hypoxanthine
Externí odkaz:
https://doaj.org/article/0199decf62f24f5d908ff7223c84e345
Autor:
Bernard A. Connolly, Rachel C. Little, Eimer Tuite, Kasid Khan, Andrew R. Pike, Colette J. Whitfield, Kuniharu Ijiro
Publikováno v:
Chemistry-A European Journal
The self-priming synthesis of multiply modified DNA by the extension of repeating unit duplex “oligoseeds” provides a source of versatile DNA. Sterically-demanding nucleotides 5-Br-dUTP, 7-deaza-7-I-dATP, 6-S-dGTP, 5-I-dCTP as well as 5-(octadiyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0d6c0a07f43ce95ee506c74309e1b7
https://zenodo.org/record/3270586
https://zenodo.org/record/3270586
Autor:
Bernard A. Connolly, Zvi Kelman, Lubomira Čuboňová, Thomas J. Santangelo, Tomas T. Richardson, John N. Reeve, Brett W. Burkhart
Publikováno v:
Journal of Bacteriology. 195:2322-2328
Three evolutionarily distinct families of replicative DNA polymerases, designated polymerase B (Pol B), Pol C, and Pol D, have been identified. Members of the Pol B family are present in all three domains of life, whereas Pol C exists only in Bacteri
Autor:
Pauline Heslop, Tomas T. Richardson, Xiaohua Wu, Anita C. Jones, Brian J. Keith, Bernard A. Connolly
Publikováno v:
Richardson, T T, Wu, X, Keith, B J, Heslop, P, Jones, A C & Connolly, B A 2013, ' Unwinding of primer-templates by archaeal family-B DNA polymerases in response to template-strand uracil ', Nucleic Acids Research . https://doi.org/10.1093/nar/gks1364
Nucleic Acids Research
Nucleic Acids Research
Archaeal family-B DNA polymerases bind tightly to deaminated bases and stall replication on encountering uracil in template strands, four bases ahead of the primer-template junction. Should the polymerase progress further towards the uracil, for exam
Autor:
Julie L. Tubbs, Geoffrey P. Margison, Bernard A. Connolly, Hannah Blackburn, Christopher L. Millington, Mary R Thorncroft, David M. Williams, Oliver J. Wilkinson, Christopher A. Hunter, John A. Tainer, Andrew S. Marriott, Rihito Morita, Gail McGown, Ryoji Masui, Jane A. Grasby, Vitaly F. Latypov, Amanda J. Watson
Publikováno v:
Proceedings of the National Academy of Sciences. 109:18755-18760
Alkyltransferase-like (ATL) proteins in Schizosaccharomyces pombe (Atl1) and Thermus thermophilus (TTHA1564) protect against the adverse effects of DNA alkylation damage by flagging O 6 -alkylguanine lesions for nucleotide excision repair (NER). We s
Autor:
Scott M. D. Watson, Bernard A. Connolly, Miguel A. Galindo, Said A. Farha Al-Said, Nicholas G. Wright, Andrew Houlton, Joseph H. Hedley, Benjamin R. Horrocks
Publikováno v:
Chemistry-A European Journal
Supramolecular polymer nanowires have been prepared by using DNA-templating of 2,5-(bis-2-thienyl)-pyrrole (TPT) by oxidation with FeCl(3) in a mixed aqueous/organic solvent system. Despite the reduced capacity for strong hydrogen bonding in polyTPT
Autor:
Rodrigo Gonzalez, Sanna Carlsson, Bernard A. Connolly, Andrew Houlton, Andrew R. Pike, Norah O'Farrell, Samson N. Patole, Benjamin R. Horrocks
Publikováno v:
Science of Advanced Materials. 3:483-489
Autor:
Bernard A. Connolly, Tom Killelea
Publikováno v:
ChemBioChem. 12:1330-1336
The family-B DNA polymerases obtained from the order Thermococcales, for example, Pyrococcus furiosus (Pfu-Pol) are commonly used in the polymerase chain reaction (PCR) because of their high thermostability and low error rates. Most of these polymera
Determinants of Precatalytic Conformational Transitions in the DNA Cytosine Methyltransferase M.HhaI
Autor:
Douglas M. Matje, Bernard A. Connolly, Dylan F. Coughlin, Norbert O. Reich, Frederick W. Dahlquist
Publikováno v:
Biochemistry. 50:1465-1473
The DNA methyltransferase M.HhaI is an excellent model for understanding how recognition of a nucleic acid substrate is translated into site-specific modification. In this study, we utilize direct, real-time monitoring of the catalytic loop position
Publikováno v:
Nucleic Acids Research
Archaeal family B polymerases bind tightly to the deaminated bases uracil and hypoxanthine in single-stranded DNA, stalling replication on encountering these pro-mutagenic deoxynucleosides four steps ahead of the primer–template junction. When urac