Výsledky vyhledávání - "Bernard Binétruy"

Akademický článek

TNF-α induces endothelial–mesenchymal transition promoting stromal development of pancreatic adenocarcinoma

Autor: Marjorie Adjuto-Saccone, Philippe Soubeyran, Julie Garcia, Stéphane Audebert, Luc Camoin, Marion Rubis, Julie Roques, Bernard Binétruy, Juan Lucio Iovanna, Roselyne Tournaire

Publikováno v: Cell Death and Disease, Vol 12, Iss 7, Pp 1-15 (2021)

Abstract Endothelial–mesenchymal transition (EndMT) is an important source of cancer-associated fibroblasts (CAFs), which facilitates tumour progression. PDAC is characterised by abundant CAFs and tumour necrosis factor-α (TNF-α). Here, we show t

Externí odkaz: https://doaj.org/article/3aa8e654cca2441fad193adeb9b1e12e

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Akademický článek

The plasminogen activation system modulates differently adipogenesis and myogenesis of embryonic stem cells.

Autor: Ola Hadadeh, Emilie Barruet, Franck Peiretti, Monique Verdier, Denis Bernot, Yasmine Hadjal, Claire El Yazidi, Andrée Robaglia-Schlupp, Andre Maues De Paula, Didier Nègre, Michelina Iacovino, Michael Kyba, Marie-Christine Alessi, Bernard Binétruy

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e49065 (2012)

Regulation of the extracellular matrix (ECM) plays an important functional role either in physiological or pathological conditions. The plasminogen activation (PA) system, comprising the uPA and tPA proteases and their inhibitor PAI-1, is one of the

Externí odkaz: https://doaj.org/article/1e5f7d84cb734b4dba74ed68d267a65e

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Efficient and Cost-Effective Generation of Mature Neurons From Human Induced Pluripotent Stem Cells

Autor: Manon Lasserre, Emilie Barruet, Galyna Maleeva, Claire El-Yazidi, Philippe Tropel, Bernard Binétruy, Cherif Badja, Frédérique Magdinier, Piotr Bregestovski

Publikováno v: Stem Cells Translational Medicine
Stem Cells Translational Medicine, 2014, 3 (12), pp.1467-1472. 〈10.5966/sctm.2014-0024〉

For years, our ability to study pathological changes in neurological diseases has been hampered by the lack of relevant models until the recent groundbreaking work from Yamanaka's group showing that it is feasible to generate induced pluripotent stem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f9c8099212157c6f16bbea8a33dedf
https://doi.org/10.5966/sctm.2014-0024

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Brown-like adipose progenitors derived from human induced pluripotent stem cells: Identification of critical pathways governing their adipogenic capacity

Autor: Kran Suknuntha, Pascal Peraldi, Annie Ladoux, Xi Yao, Phi Villageois, Anne-Laure Hafner, Karima Annab, Bernard Binétruy, Christophe Ravaud, Igor I. Slukvin, Julian Contet, Christian Dani

Publikováno v: Scientific Reports
Scientific Reports, 2016, 6, ⟨10.1038/srep32490⟩
Scientific Reports, Nature Publishing Group, 2016, 6, ⟨10.1038/srep32490⟩

Human induced pluripotent stem cells (hiPSCs) show great promise for obesity treatment as they represent an unlimited source of brown/brite adipose progenitors (BAPs). However, hiPSC-BAPs display a low adipogenic capacity compared to adult-BAPs when

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0ac00a509839ca12efe9948fe8f31a
https://doi.org/10.1038/srep32490

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Concise Review: Regulation of Embryonic Stem Cell Lineage Commitment by Mitogen-Activated Protein Kinases

Autor: Lynn E. Heasley, Frédéric Bost, Bernard Binétruy, Myriam Aouadi, Leslie Caron

Publikováno v: Stem Cells. 25:1090-1095

Embryonic stem (ES) cells can give rise, in vivo, to the ectodermal, endodermal, and mesodermal germ layers and, in vitro, can differentiate into multiple cell lineages, offering broad perspectives in regenerative medicine. Understanding the molecula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1cc359956288733df534843e9522669
https://doi.org/10.1634/stemcells.2006-0612

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Long-Term Treatment with Lopinavir-Ritonavir Induces a Reduction in Peripheral Adipose Depots in Mice

Autor: Jacques Durant, Yannick Le Marchand-Brustel, Pierre Dellamonica, Bernard Binétruy, Christophe Perrin, Laurence Heripret, Myriam Aouadi, Rodolphe Garraffo, Matthieu Prot, Thibaud Lavrut, Nathalie Cardot-Leccia

Publikováno v: Antimicrobial Agents and Chemotherapy. 50:3998-4004

Highly active antiretroviral therapy (HAART) of human immunodeficiency virus-infected patients is associated with adverse effects, such as lipodystrophy and hyperlipidemia. The lipodystrophic syndrome is characterized by a peripheral lipoatrophy and/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ac1b7035899bda55e40f688f1eb707
https://doi.org/10.1128/aac.00625-06

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p38 Mitogen‐Activated Protein Kinase Activity Commits Embryonic Stem Cells to Either Neurogenesis or Cardiomyogenesis

Autor: Bernard Binétruy, Myriam Aouadi, Kathiane Laurent, Leslie Caron, Frédéric Bost, Yannick Le Marchand Brustel

Publikováno v: STEM CELLS. 24:1399-1406

Mouse embryonic stem (ES) cells can be differentiated, in vitro into a variety of cell types including cardiac cells and neurons. This process is strictly controlled by the potent morphogen retinoic acid (RA). At a concentration of 10(-7) M, RA induc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb9fa56df1ad0ca2502f22f894e7ebf
https://doi.org/10.1634/stemcells.2005-0398

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Inhibition of p38MAPK Increases Adipogenesis From Embryonic to Adult Stages

Autor: Yannick Le Marchand-Brustel, Bernard Binétruy, Myriam Aouadi, Frédéric Bost, Kathiane Laurent, Matthieu Prot

Publikováno v: Diabetes. 55:281-289

Formation of new adipocytes from precursor cells contributes to adipose tissue expansion and obesity. In this study, we asked whether p38 mitogen-activated protein kinase (MAPK) pathway regulates normal and pathological adipogenesis. In both dietary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0707e866f0b72475cb6cc6e2a713d92
https://doi.org/10.2337/diabetes.55.02.06.db05-0963

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Obésité, Diabète et insulinorésistance. Altérations du message insulinique

Autor: T Grémeaux, Yannick Le Marchand-Brustel, Jean-François Tanti, Myriam Aouadi, Bernard Binétruy, Frédéric Bost, Philippe Gual

Publikováno v: Journal de la Société de Biologie. 200:93-97

L'obesite est tres souvent associee au diabete et a l'insulinoresistance. Cette revue resume les resultats, obtenus dans notre groupe, concernant le role de la phosphorylation sur serine d'IRS1 dans l'inhibition du signal insulinique. Nous presentero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a88d409c2765c110c39282ecb3559121
https://doi.org/10.1051/jbio:2006012

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