Výsledky vyhledávání - "Bernard, Martinet"

Akademický článek

MHC Class I Masking to Prevent AMR in a Porcine Kidney Transplantation Model in Alloimmunized Recipients

Autor: Delphine Kervella, MD, PhD, Julien Branchereau, MD, PhD, Thomas Prudhomme, MD, Véronique Nerrière-Daguin, BSc, Karine Renaudin, MD, PhD, David Minault, Jérémy Hervouet, Bernard Martinet, Sarah Bruneau, PhD, Stéphanie Le Bas-Bernardet, PhD, Gilles Blancho, MD, PhD

Publikováno v: Transplantation Direct, Vol 9, Iss 6, p e1490 (2023)

Background:. Presensitized patients awaiting a kidney transplant have a lower graft survival and a longer waiting time because of the limited number of potential donors and the higher risk of antibody-mediated rejection (AMR), particularly in the ear

Externí odkaz: https://doaj.org/article/bbd663527a61467bb60ed243e0eaed38

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Akademický článek

IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Chronic inflammation often involves reactivation of memory adaptive immune. Here the authors show, using non-human primate models, that a single dose of anti-IL-7 receptor monoclonal antibody that exhibits antagonist but not agonist properties can re

Externí odkaz: https://doaj.org/article/2f8d89dcfb614001945d31eee5d1a5ce

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Akademický článek

Anti-EBOV GP IgGs Lacking α1-3-Galactose and Neu5Gc Prolong Survival and Decrease Blood Viral Load in EBOV-Infected Guinea Pigs.

Publikováno v: PLoS ONE, Vol 11, Iss 6, p e0156775 (2016)

Polyclonal xenogenic IgGs, although having been used in the prevention and cure of severe infectious diseases, are highly immunogenic, which may restrict their usage in new applications such as Ebola hemorrhagic fever. IgG glycans display powerful xe

Externí odkaz: https://doaj.org/article/3c48cfab991749ad839dcf1c00ecbd4f

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Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2020, 130 (11), pp.6109-6123. ⟨10.1172/JCI135528⟩
Journal of Clinical Investigation, 2020, 130 (11), pp.6109-6123. ⟨10.1172/JCI135528⟩
J Clin Invest

International audience; T cell exclusion causes resistance to cancer immunotherapies via immune checkpoint blockade (ICB). Myeloid cells contribute to resistance by expressing signal regulatory protein-α (SIRPα), an inhibitory membrane receptor tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19a5d1d3edf746100f79d51f25bf360
https://doi.org/10.1172/jci135528

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Terminally Differentiated Effector Memory CD8+ T Cells Identify Kidney Transplant Recipients at High Risk of Graft Failure

Autor: Yohann Foucher, Pierrick Guerif, Nicolas Degauque, Sophie Brouard, Richard Danger, Florent Delbos, Gaëlle Tilly, Lola Jacquemont, Magali Giral, Bernard Martinet, Michelle Yap, Tra-My Doan-Ngoc

Publikováno v: Journal of the American Society of Nephrology. 31:876-891

Background Identifying biomarkers to predict kidney transplant failure and to define new therapeutic targets requires more comprehensive understanding of the immune response to chronic allogeneic stimulation. Methods We investigated the frequency and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90762890a959fb425c763b9c4e5eb97b
https://doi.org/10.1681/asn.2019080847

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SIRPα/CD47 axis controls the maintenance of transplant tolerance sustained by myeloid-derived suppressor cells

Autor: Bernard Vanhove, Bernard Martinet, Vanessa Gauttier, Sabrina Pengam, Virginie Thepenier, Véronique Daguin, Karine Renaudin, Nicolas Poirier, Justine Durand, Caroline Mary, Géraldine Teppaz, Claire Usal, Gilles Blancho, Nahzli Dilek

Publikováno v: American Journal of Transplantation
American Journal of Transplantation, Wiley, 2019, ⟨10.1111/ajt.15497⟩
American Journal of Transplantation, 2019, ⟨10.1111/ajt.15497⟩

International audience; Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature hematopoietic precursors known to suppress immune responses. Interaction of SIRP alpha (SIRPα), expressed by myeloid cells, with the ubiquitou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53905147eca8580b9b43888df2565bc1
https://doi.org/10.1111/ajt.15497

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Neutrophil-derived extracellular vesicles induce endothelial inflammation and damage through the transfer of miRNAs

Autor: Alexandre Glémain, Mélanie Néel, Antoine Néel, Gwennan André-Grégoire, Julie Gavard, Bernard Martinet, Rozenn Le Bloas, Kevin Riquin, Mohamed Hamidou, Fadi Fakhouri, Sarah Bruneau

Publikováno v: Journal of Autoimmunity
Journal of Autoimmunity, 2022, 129, pp.102826. ⟨10.1016/j.jaut.2022.102826⟩

International audience; The critical role of neutrophils in pathological inflammation, notably in various autoimmune disorders, is currently the focus of renewed interest. Here, we demonstrate for the first time that activation of neutrophils with va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76353284d363542c936aac043fba26d9
https://doi.org/10.1016/j.jaut.2022.102826

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Terminally Differentiated Effector Memory CD8

Autor: Lola, Jacquemont, Gaëlle, Tilly, Michelle, Yap, Tra-My, Doan-Ngoc, Richard, Danger, Pierrick, Guérif, Florent, Delbos, Bernard, Martinet, Magali, Giral, Yohann, Foucher, Sophie, Brouard, Nicolas, Degauque

Publikováno v: J Am Soc Nephrol

BACKGROUND: Identifying biomarkers to predict kidney transplant failure and to define new therapeutic targets requires more comprehensive understanding of the immune response to chronic allogeneic stimulation. METHODS: We investigated the frequency a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2ba8911da65695b552f117e377a2511a
https://pubmed.ncbi.nlm.nih.gov/32165419

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Transient antibody targeting of CD45RC induces transplant tolerance and potent antigen-specific regulatory T cells

Autor: Séverine Bézie, Laetitia Boucault, Carole Guillonneau, Véronique Daguin, Laurent David, Bernard Martinet, Elodie Autrusseau, Stéphanie Kilens, Eric Charpentier, Audrey Donnart, Elodie Picarda, Dimitri Meistermann, Ignacio Anegon

Publikováno v: JCI Insight. 2

Rat and human CD4(+) and CD8(+) Tregs expressing low levels of CD45RC have strong immunoregulatory properties. We describe here that human CD45 isoforms are nonredundant and identify distinct subsets of cells. We show that CD45RC is not expressed by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0453807b480c684bddf61ce0dcc31e
https://doi.org/10.1172/jci.insight.90088

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Anti-EBOV GP IgGs Lacking α1-3-Galactose and Neu5Gc Prolong Survival and Decrease Blood Viral Load in EBOV-Infected Guinea Pigs

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2016, 11 (6), pp.e0156775. ⟨10.1371/journal.pone.0156775⟩
PLoS ONE, 2016, 11 (6), pp.e0156775. ⟨10.1371/journal.pone.0156775⟩
Plos One 6 (11), . (2016)
PLoS ONE, Vol 11, Iss 6, p e0156775 (2016)

International audience; Polyclonal xenogenic IgGs, although having been used in the prevention and cure of severe infectious diseases, are highly immunogenic, which may restrict their usage in new applications such as Ebola hemorrhagic fever. IgG gly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96899d375f43b7fd48f0c1f1c282dcd1
https://hal.archives-ouvertes.fr/hal-01908862/document

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